Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease -

Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease

Jörg Striessnig (Herausgeber)

Buch | Softcover
XII, 316 Seiten
2024 | 2023
Springer International Publishing (Verlag)
978-3-031-38439-4 (ISBN)
160,49 inkl. MwSt

The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.

Preface.- Part 1 Modulation.-  Cav1.1Calcium Channel Signaling Complexes in Excitation-Contraction Coupling: Insights from Channelopathies.- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia.- Sympathetic Nervous System Regulation of Cardiac Calcium Channels.- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19.- Part 2 Pharmacological Approaches.- Pathophysiological Roles of Auxiliary Calcium Channel 2d Subunits.- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors.- Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies.-    CACNA1C-Related Channelopathies.- CACNA1D-Related Channelopathies: From Hypertension to Autism.- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options.- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies.- Pathophysiological Roles of Auxiliary Calcium Channel 2d Subunits.


Erscheinungsdatum
Reihe/Serie Handbook of Experimental Pharmacology
Zusatzinfo XII, 316 p. 100 illus., 30 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 559 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Studium 1. Studienabschnitt (Vorklinik) Physiologie
Studium 2. Studienabschnitt (Klinik) Humangenetik
Schlagworte Ca2+ channel blockers • Ca2+ channelopathies • Ca2+ channels • channel-interacting proteins • therapies of rare diseases
ISBN-10 3-031-38439-3 / 3031384393
ISBN-13 978-3-031-38439-4 / 9783031384394
Zustand Neuware
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