Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease
Springer International Publishing (Verlag)
978-3-031-38436-3 (ISBN)
The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.
Preface.- Part 1 Modulation.- Cav1.1Calcium Channel Signaling Complexes in Excitation-Contraction Coupling: Insights from Channelopathies.- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia.- Sympathetic Nervous System Regulation of Cardiac Calcium Channels.- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19.- Part 2 Pharmacological Approaches.- Pathophysiological Roles of Auxiliary Calcium Channel 2d Subunits.- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors.- Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies.- CACNA1C-Related Channelopathies.- CACNA1D-Related Channelopathies: From Hypertension to Autism.- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options.- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies.- Pathophysiological Roles of Auxiliary Calcium Channel 2d Subunits.
| Erscheinungsdatum | 02.08.2023 |
|---|---|
| Reihe/Serie | Handbook of Experimental Pharmacology |
| Zusatzinfo | XII, 316 p. 100 illus., 30 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 700 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Medizin / Pharmazie ► Pharmazie | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Schlagworte | Ca2+ channel blockers • Ca2+ channelopathies • Ca2+ channels • channel-interacting proteins • therapies of rare diseases |
| ISBN-10 | 3-031-38436-9 / 3031384369 |
| ISBN-13 | 978-3-031-38436-3 / 9783031384363 |
| Zustand | Neuware |
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