Principles of Medical Biochemistry

Dr. Meisenberg emailed us Jan. 24, 2019 to note his updated email address meisenberggerhard@gmail.com since he has now officially retired from his university position.

Table of Contents Part One: Principles of Molecular Structure and Function. Chapter 1: Introduction to Biomolecules. WATER: THE SOLVENT OF LIFE. COVALENT BONDS AND NONCOVALENT INTERACTIONS THE MAJOR CLASSES OF BIOMOLECULES. Chapter 2: Protein structure. THE AMINO ACIDS. LEVELS OF PROTEIN STRUCTURE THE PHYSICAL PROPERTIES OF PROTEINS Chapter 3: Oxygen Transporters: Hemoglobin and Myoglobin. Chapter 4: Enzymatic Reactions. THERMODYNAMICS ENZYME KINETICS ENZYME INHIBITION REACTION TYPES AND REACTION MECHANISMS Chapter 5:Coenzymes Part Two: Cell and Tissue Structure. Chapter 6: Biological Membranes. THE LIPID BILAYER. MEMBRANE PROTEINS. MEMBRANE TRANSPORT. Chapter 7: The Cytoskeleton Chapter 8: The Extracellular Matrix. FIBROUS PROTEINS OF THE EXTRACELLULAR MATRIX. THE AMORPHOUS GROUND SUBSTANCE Part Three: Genetic Information: DNA, RNA, and Protein Synthesis. Chapter 9: DNA, RNA, and Protein Synthesis: The Central Dogma of Molecular Biology. DNA STRUCTURE AND DNA REPLICATION. RNA AND THE GENETIC CODE. PROTEIN SYNTHESIS. REGULATION OF GENE EXPRESSION. Chapter 10: Viruses Chapter 11: The Human Genome and Its Expression. CHROMATIN STRUCTURE. THE ARCHITECTURE OF THE HUMAN GENOME. TRANSCRIPTION AND TRANSLATION. Chapter 12: The processing and targeting of proteins. Chapter 13: Introduction to Genetic Diseases. MUTATIONS AND DNA REPAIR. THE HEMOGLOBINOPATHIES. Chapter 14: DNA Technology. THE TOOLS. THE DIAGNOSIS OF GENETIC DISORDERS. CLONING IN MICROORGANISMS. GENE THERAPY. Part Four: Signaling and signaling cascades. Chapter 15: The Blood. THE COMPONENTS OF PLASMA PLASMA PROTEINS. THE IMMUNOGLOBULINS. THE BLOOD CLOTTING SYSTEM. CLINICAL LABORATORY DIAGNOSIS. Chapter 16: Extracellular Messengers. THE STEROID HORMONES. THE THYROID HORMONES. THE BIOGENIC AMINES PEPTIDES AND PROTEINS THE EICOSANOIDS NEUROTRANSMITTERS. Chapter 17: Intracellular Messengers. RECEPTORS. G PROTEINS, SECOND MESSENGERS, AND PROTEIN KINASES. RECEPTORS WITH ENZYMATIC ACTIVITIES. Chapter 18: Cellular Growth Control and Cancer. CELL CYCLE CONTROL. MITOGENIC SIGNALING. SOMATIC MUTATIONS AND CANCER. SPECIFIC CANCERS. Part Five: Metabolism. Chapter 19: Digestive Enzymes. Chapter 20: Introduction to Metabolism. Chapter 21: The Oxidation of Glucose: Glycolysis, the TCA Cycle, and Oxidative Phosphorylation. GLYCOLYSIS: FROM GLUCOSE TO PYRUVATE. PYRUVATE DEHYDROGENASE AND THE TCA CYCLE: FROM PYRUVATE TO CARBON DIOXIDE AND REDUCED COENZYMES. THE RESPIRATORY CHAIN AND OXIDATIVE PHOSPHORYLATION. INHIBITION OF OXIDATIVE METABOLISM Chapter 22: Carbohydrate Metabolism. GLUCONEOGENEIS. GLYCOGEN METABOLISM. THE METABOLISM OF FRUCTOSE AND GALACTOSE. THE MINOR PATHWAYS OF CARBOHYDRATE METABOLISM. Chapter 23: The Metabolism of Fatty Acids and Triglycerides. THE GENERATION OF METABOLIC ENERGY FROM FATTY ACIDS. FROM CARBOHYDRATE TO FAT. Chapter 24: The Metabolism of Membrane Lipids. THE METABOLISM OF PHOSPHOGLYCERIDES AND SPHINGOLIPIDS. CHOLESTEROL METABOLISM. Chapter 25: Lipid Transport. THE HIGHWAYS OF LIPID TRANSPORT. LIPOPROTEINS AND ATHEROSCLEROSIS. Chapter 26: Amino Acid Metabolism. THE FATE OF THE AMINO NITROGEN. AMINO ACID DEGRADATION. Chapter 27: Heme Metabolism. Chapter 28: The Metabolism of Purines and Pyrimidines. Chapter 29: Vitamins and Minerals. THE WATER-SOLUBLE VITAMINS. THE FAT-SOLUBLE VITAMINS. THE TRACE MINERALS. Chapter 30: Integration of Metabolism. HORMONAL REGULATION. FEEDING AND FASTING DIABETES MELLITUS. PHYSICAL EXERCISE. THE METABOLISM OF XENOBIOTICS.