Purinergic Signaling in Neurodevelopment, Neuroinflammation and Neurodegeneration (eBook)

This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine, act in neuronal transmission, control of synaptic activity, proliferation, differentiation and cell death regulation in the CNS. This book focuses on the participation of purinergic receptors and ectonucleotidases, degrading ATP into adenosine, in embryonic and adult neurogenesis in vitro and in vivo as well as in synaptic transmission and pathophysiology. Further, the chapters discuss varying brain diseases, including Parkinson's, and Alzheimer's disease, autism, mood disorders and epilepsy, as well as brain tumors, in the context of purinergic signaling and its clinical aspects. The development of purinergic receptor agonists is also an important issue of this book. This book provides a critical review of the current state of science and will be useful for both scientists and students who are or would like to get involved in this area. Furthermore, this book addresses neuroscientists, physician and professionals from the industry, who would like to update themselves in this exciting and rapidly growing field of neuroscience.

Dr. Talita Glaser studied Biology at São Paulo University (Brazil) and performed her PhD thesis in Biochemistry and Neuroscience at the same university. She completed her training during PhD in Kyoto University followed by postdoctoral research training at the University of São Paulo and Harvard Medical School. She is actually a postdoctoral fellow at the laboratory of Prof. Henning Ulrich at the University of São Paulo. Even as a young investigator, her work on purinergic signalling and stem cells are well cited and known internationally. Dr. Glaser has published over 40 papers in peer-reviewed journals and (H-factor of 19, ca. 1284 citations)  6 book chapters. The results of her research were commented on by major Brazilian newspapers.