Williams Hematology, Seventh Edition

Marshall Lichtman, M.D.Professor of MedicineUniversity of Rochester School of MedicineRochester, NY Ernest Beutler, M.D. Professor and Chairman Dept. of Molecular Medicine and Experimental Biology The Scripps Research Institute La Jolla, CA Senior Vice President, Health Sciences Dean, School of Medicine Stony Brook University Stony Brook, NY Evelyn and Edwin Tasch Chair in Cancer Research Professor of Medicine Division of Hematology/OncologyDeputy Director for Research Operations Moores UCSD Cancer Center University of California, San Diego La Jolla, California Professor of Medicine, Pathology, and Genetics Hematology Division University of Utah Salt Lake City, Utah Department of Pathophysiology First Faculty of Medicine Charles University in Prague Czech Republic

Contributors
Preface
SI Unit Conversion Table
Part I: Clinical Evaluation of the Patient
1. Initial Approach to the Patient: History and Physical Examination, Marshall A. Lichtman and Ernest Beutler
2. Examination of the Blood, Daniel C. Ryan
3. Examination of the Marrow, Daniel H. Ryan and Raymond E. Felgar
Part II: General Hematology
4. Structure of the Marrow and the Hematopoietic Microenvironment, Camille N. Abboud and Marshall A. Lichtman
5. The Lymphoid Tissues, Thomas J. Kipps
6. Hematology of the Newborn, George B. Segel and James Palis
7. Hematology During Pregnancy, Martha P. Mims and Josef T. Prchal
8. Hematology in Older Persons, Michelle Shayne and Marshall A. Lichtman
Part III: Molecular and Cellular Hematology
9. Genetic Principles and Molecular Biology, Ernest Beutler
10. Cytogenetics and Gene Rearrangement, Lucy A. Godley and Michelle M. Le Beau
11. Apoptosis, Roberta A. Gottlieb
12. Cell Cycle Regulation and Hematological Disorders, Mathias Schmid and Dennis A. Carson
13. Signal Transduction Pathways, Kenneth Kaushansky
14. The Cluster of Differentiation (CD) Antigens, Thomas J. Kipps
15. Hematopoietic Stem Cells, Progenitors, and Cytokines, Kenneth Kaushansky
16. The Inflammatory Response, Jeffrey S. Warren and Peter A. Ward
17. Innate Immunity, Bruce Beutler
18. Dendritic Cells and the Control of Innate and Adaptive Immunity, Madhav Dhodapkar and Ralph M. Steinman
Part IV: Therapeutic Principles
19. Pharmacology and Toxicity of Antineoplastic Drugs, Bruce A. Chabner, Wyndham Wilson, and Jeffrey Supko
20. Treatment of Infections in the Immunocompromised Host, Steven Beutler
21. Principles of Antithrombotic Therapy, Charles W. Francis and Karen L. Kaplan
22. Principles of Hematopoietic Cell Transplantation, Robert S. Negrin and Karl G. Blume
23. Principles of Immune Cell Therapy, Carolina Berger and Stanley R. Riddell
24. Principles of Vaccine Therapy, Larry W. Kwak
25. Principles of Therapeutic Apheresis: Indications, Efficacy, Complications, Bruce C. McLeod
26. Principles of Gene Transfer for Therapy, Januario E. Castro and Thomas J. Kipps
27. Pain Management, Weonjeong Lim, KaMala S. Thomas, and Joel E. Dimsdale
Part V: The Erythrocyte
28. Morphology of the Erythron, Brian S. Bull
29. Composition of the Erythrocyte, Ernest Beutler
30. Production of Erythrocytes, Josef T. Prchal
COLOR PLATES I-XXV (BETWEEN PAGES 404 AND 405)
31. Destruction of Erythrocytes, Ernest Beutler
32. Clinical Manifestations and Classification of Erythrocyte Disorders, Josef T. Prchal
33. Aplastic Anemia, George B. Segel and Marshall A. Lichtman
34. Pure Red Cell Aplasia, Neal S. Young
35. Anemia of Chronic Renal Failure, Jaime Caro
36. Anemia of Endocrine Disorders, Xylina T. Gregg and Josef T. Prchal
37. The Congenital Dyserythropoietic Anemias, Ernest Beutler
38. Paroxysmal Nocturnal Hemoglobinuria, Ernest Beutler
39. Folate, Cobalamin, and Megaloblastic Anemias, Bernard M. Babior
40. Disorders of Iron Metabolism, Ernest Beutler
41. Anemia Resulting from Other Nutritional Dificiencies, Ernest Beutler
42. Anemia Associated with Marrow Infiltration, Josef T. Prchal
43. Anemia of Chronic Disease, Tomas Ganz
44. Disorders of the Red Blood Cell Membrane: Hereditary Spherocytosis, Elliptocytosis, and Related Disorders, Patrick G. Gallagher
45. Disorders of Red Cells Resulting from Enzyme Abnormalities, Ernest Beutler
46. Disorders of Globin Synthesis: The Thalassemias, David J. Weatherall
47. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities, Ernest Beutler
48. Methemoglobinemia and Other Causes of Cyanosis, Ernest Beutler
49. Hemolytic Anemia Resulting from Physical Injury to Red Cells, Kelty R. Baker and Joel Moake
50. Hemolytic Anemia Resulting from Chemical and Physical Agents, Ernest Beutler
51. Hemolytic Anemia Resulting from Infections with Microorganisms, Ernest Beutler
52. Hemolytic Anemia Resulting from Immune Injury, Charles H. Packman
53. Alloimmune Hemolytic Disease of the Newborn, Jayashree Ramasethu and Naomi L.C. Luban
54. Acute Blood Loss Anemia, Robert S. Hillman and Chaim Hershko
55. Hypersplenism and Hyposplenism, Jaime Caro
56. Primary and Secondary Polycythemias (Erythrocytotis), Josef T. Prchal and Ernest Beutler
57. The Hematologic Aspects of Porphyria, Shigeru Sassa
58. Hereditary and Acquired Sideroblastic Anemias, Ernest Beutler
Part VI: Neutrophils, Eosinophils, Basophils, and Mast Cells
59. Morphology of Neutrophils, Eosinophils, and Basophils, Dorothy Ford Bainton
60. Composition of Neutrophils, C. Wayne Smith
61. Production, Distribution, adn Fate of Neutrophils, C. Wayne Smith
62. Eosinophils and Their Disorders, Andrew Wardlaw
63. Basophils and Mast Cells and Their Disorders, Stephen J. Galli, Dean D. Metcalfe, Daniel A. Arber, and Ann M. Dvorak
64. Classification and Clinical Manifestations of Neutrophil Disorders, Marshall A. Lichtman
65. Neutropenia and Neutrophilia, David C. Dale
66. Disorders of Neutrophil Function, Niels Borregaard and Laurence A. Boxer
Part VII: Monocytes and Macrophages
67. Morphology of Monocytes and Macrophages, Steven D. Douglas and Wen-Zhe Ho
68. Biochemistry and Function of Monocytes and Macrophages, Robert I. Lehrer and Tomas Ganz
69. Production, Distribution, and Fate of Monocytes and Macrophages, Tomas Ganz and Robert I. Lehrer
70. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages, Marshall A. Lichtman
71. Monocytosis and Monocytopenia, Marshall A. Lichtman
72. Inflammatory and Malignant Histiocytosis, Marshall A. Lichtman
73. Lipid Storage Diseases, Ernest Beutler
Part VIII: Lymphocytes and Plasma Cells
74. Morphology of Lymphocytes and Plasma Cells, Stephen M. Baird
75. Composition and Biochemistry of Lymphocytes and Plasma Cells, Thomas J. Kipps and Dennnis A. Carson
76. Lymphopoiesis, Tucker W. LeBien
77. Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production, Thomas J. Kipps
78. Functions of T Lymphocytes: T Cell Receptors for Antigen
79. Functions of Natural Killer Cells, Giorgio Trinchieri and Lewis L. Lanier
80. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders, Thomas J. Kipps
81. Lymphocytes and Lymphocytopenia, Thomas J. Kipps
82. Immunodeficiency Diseases, Harry W. Schroeder, Jr. and Max D. Cooper
83. Hematological Aspects of Human Immunodeficiency Syndrome, Soon Thye Lim and Alexandra M. Levine
84. Mononucleosis Syndromes, Robert F. Betts
Part IX: Malignant Diseases
85. Classification and Clinical Manifestations of the Clonal Myeloid Disorders, Marshall A. Lichtman
86. Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Leukemia), Marshall A. Lichtman and Jane L. Liesveld
87. Acute Myelogenous Leukemia, Jane L. Liesveld and Marshall A. Lichtman
88. Chronic Myelogenous Leukemia and Related Disorders, Marshall A. Lichtman and Jane L. Liesveld
89. Idiopathic Myelofibrosis (Myelofibrosis with Myeloid Metaplasia), Marshall A. Lichtman
90. Classification of Malignant Lymphoid Disorders, Thomas J. Kipps
91. Acute Lymphoblastic Leukemia, Ching-Hon Pui
92. Chronic Lymphocytic Leukemia and Related Diseases, Thomas J. Kipps
93.Hairy Cell Leukemia, Alan Saven
94. Large Granular Lymphocytic Leukemia, Thomas P. Loughran and Marshall E. Kadin
95. Pathology of Lymphomas, Randy D. Gascoyne and Brian F. Skinnider
96. The Non-Hodgkin Lymphomas, Kenneth A. Foon, Irene Ghobrial, Larisa J. Geskin, and Samuel A. Jacobs
97. Hodgkin Lymphoma, Sandra J. Horning
98. Plasma Cell Neoplasms: General Considerations, Stephen M. Baird
99. Essential Monoclonal Gammopathies, Marshall A. Lichtman
100. Plasma Cell Myeloma, Bart Barlogie, John Shaughnessy, Joshua Epstein, Ralph Sanderson, Elias Anaissie, Ronald Walker, and Guido Tricot
101. The Amyloidoses, Daniel R. Jacobson, David C. Seldin, and Joel N. Buxbaum
102. Macroglobulinemia, Thomas J. Kipps
103. Heavy Chain Diseases, Joel N. Buxbaum and Alice Alexander
Part X: Hemostasis and Thrombosis
104. Megakaryopoiesis and Thrombopoiesis, Kenneth Kaushansky
105. Platelet Morphology, Biochemistry, and Function, Leslie V. Parise, Susan S. Smyth, Arun S. Shet, and Barry S. Coller
106. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostatis, Harold R. Roberts, Dougald M. Monroe III, and Maureane Hoffman
107. Control of Coagulation Reactions, John H. Griffin
108. Vascular Function in Hemostatis, Katherine A. Hajjar, Naomi L. Esmon, Aaron J. Marcus, and William Muller
109. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostatis, Uri Seligsohn and Kenneth Kaushansky
110. Thrombocytopenia, Reyhan Diz-Kucukkaya, Francisca C. Gushiken, and Jose A. Lopez
111. Essential Thrombocythemia and Thrombocytosis, Andrew I. Schafer
112. Hereditary Qualitative Platelet Disor
ders, Barry S. Coller, W. Beau Mitchell, and Deborah L. French
113. Acquired Qualitative Platelet Disorders, Charles S. Abrams, Sanford J. Shattil, and Joel S. Bennett
114. The Vascular Purpuras, Phillip H.A. Lee and Richard L. Gallo
115. Hemophilia A and Hemophilia B, Harold R. Roberts, Miguel Escobar, and Gilbert C. White II
116. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors, Uri Seligsohn, Ariella Zivelin, and Aida Inbal
117. Hereditary Fibrinogen Abnormalities, Michael W. Mosesson
118. Von Willebrand Disease, Jill Johnsen and David Ginsburg
119. Antibody-Mediated Coagulation Factor Deficiencies, Jozef Vermylen and Jef Arnout
120. Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation, Ton Lisman and Philip G. de Groot
121. Disseminated Intravascular Coagulation, Uri Seligsohn and W. Keith Hoots
122. Hereditary Thrombophilia, Uri Seligsohn and John H. Griffin
123. The Antiphospholipid Syndrome, Jacob H. Rand and Lisa Senzel
124. Antibody-Mediated Thrombotic Disorders: Idiopathic Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia, J. Evan Sadler and Mortimer Poncz
125. Venous Thrombosis, Gary E. Raskob, Russell D. Hull, and Graham F. Pineo
126. Atherothrombosis: Disease Initiation, Progression, and Treatment, Emile R. Mohler III and Andrew I. Schaafer
127. Fibrinolysis and Thrombolysis, Katherine A. Hajjar and Charles W. Francis
Part XI: Transfusion Medicine
128. Erythrocyte Antigens and Antibodies, Marion E. Reid, Loni Calhoun, and Lawrence D. Petz
129. Human Leukocyte and Platelet Antigens, Karen A. Sullivan and Thomas J. Kipps
130. Blood Procurement and Screening, Jeffrey McCullough
131. Preservation and Clinical Use of Erythrocytes and Whole Blood, Ernest Beutler
132. Preservation and Clinical Use of Platelets, Ralph Vassallo and Scott Murphy
Index