Williams Hematology

Marshall Lichtman, M.D.Professor of MedicineUniversity of Rochester School of MedicineRochester, NY Evelyn and Edwin Tasch Chair in Cancer Research Professor of Medicine Division of Hematology/OncologyDeputy Director for Research Operations Moores UCSD Cancer Center University of California, San Diego La Jolla, California

Part I: Clinical Evaluation of the Patient 1: Approach to the Patient. 2: Examination of the Blood. 3: Examination of the Marrow. Part II: General Hematology. 4: Structure of the Marrow. 5: Spleen and Other Lymphoid Tissues. 6: The Inflammatory Response. 7: Hematology of The Newborn. 8: Hematology in The Aged. Part III: Molecular and Cellular Hematology. 9: Genetic Principles and Molecular Biology. 10: Cytogenetics and Gene Rearrangement. 11: Apoptosis. 12: Principles of Cell Regulation. 13: The Cluster of Differentiation (CD) Antigens. 14: Hematopoietic Stem Cells, Progenitor Cells, and Cytokines. 15: Immune Accessory Molecules and Signal Transduction. Part IV: Therapeutic Principles. 16: Pharmacology and Toxicity of Antineoplastic Drugs. 17: Treatment of Infections in The Immunocompromised Host. 18: Allogeneic and Autologous Stem Cell Transplantation. 19: Gene Therapy. 20: The Use of Venous Access Devices. 21: Pain Management. Part V: The Erythrocyte. 22: Morphology of The Erythron. 23: Composition of The Erythrocyte. 24: Iron Metabolism. 25: Metabolic Aspects of Folic Acid and Cobalamin. 26: Energy Metabolism and Maintenance of Erythrocytes. 27: The Red Cell Membrane 28: Structure and Function of Hemoglobin. 29: Production and Destruction of Erythrocytes. 30: Clinical Manifestations and Classification of Erythrocyte Disorders. 31: Aplastic Anemia. 32: Pure Red Cell Aplasia. 33: Anemia of Chronic Renal Failure. 34: Anemia of Endocrine Disorders. 35: The Congenital Dyserythropoietic Anemias. 36: Paroxysmal Nocturnal Hemoglobinuria. 37: The Megaloblastic Anemias. 38: Iron Deficiency. 39: Anemia Due to Other Nutritional Deficiencies. 40: Anemia Associated With Marrow Infiltration. 41: Anemia of Chronic Disease. 42: Disorders of Iron Transport and Storage. 43: Hereditary Spherocytosis, Elliptocytosis and Related Disorders. 44: Acanthocytosis, Stomatocytosis, and Related Disorders. 45: G 6 Phosphate Dehydrogenase Deficiency and Other Red Cell Enzyme Abnormalities. 46: The Thalassemias. 47: The Sickle Cell Diseases and Related Disorders. 48: Hemoglobinopathies Associated With Unstable Hemoglobin. 49: Methemoglobinemia and Other Causes of Cyanosis. 50: Traumatic Cardiac Hemolytic Anemia. 51: Microangiopathic Hemolytic Anemia. 52: March Hemoglobinuria, Sports Anemia, and Space Anemia. 53: Hemolytic Anemia Due to Chemical and Physical Agents. 54: Hemolytic Anemia Due to Infections With Microorganisms. 55: Acquired Hemolytic Anemia Due to Warm- Reacting Autoantibodies. 56: Cryopathic Hemolytic Syndromes 57: Drug- Related Immune Hemolytic Anemia. 58: Alloimmune Hemolytic Disease of the Newborn. 59: Acute Blood Loss Anemia. 60: Hypersplenism and Hyposplenism. 61: Polycythemia. 62: The Hematologic Aspects of Porphyria. 63: Hereditary and Acquired Sideroblastic Anemias. Part VI: Neutrophils, Eosinophils, Basophils and Mast Cells. 64: Morphology of Neutrophils, Eosinophils, and Basophils. 65: Composition of Neutrophils. The Metabolism of Neutrophils 66: Production, Distribution, and Fate of Neutrophils. 67: Functions of Neutrophils. 68: Eosinophils and Their Disorders. 69: Production, Biochemistry, and Function of Basophils and Mast Cells. Basophilopenia, Basophilia, and Mastocytosis. 70: Classification and Clinical Manifestations of Neutrophil Disorders. 71: Neutropenia. and Neutrophilia. 72: Neutrophil Disorders: Qualitative Abnormalities of the Neutrophil. Part VII: Monocytes and Macrophages. 73: Morphology of Monocytes and Macrophages. 74: Biochemistry and Function of Monocytes and Macrophages. 75: Production, Distribution, and Fate of Monocytes and Macrophages. 76: Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages. 77: Monocytosis and Monocytopenia. 78: Inflammatory and Malignant Histiocytosis. 79: Lipid Storage Diseases. Part VIII: Lymphocytes and Plasma Cells. 80: Morphology of Lymphocytes and Plasma Cells. 81: Composition and Biochemistry of Lymphocytes and Plasma Cells. 82: Lymphoid Ontogeny and Homing Receptors. 83: Functions of B Lymphocytes and Plasma Cells in Immunoglobulin. 84: Functions of T Lymphocytes: T-Cell Receptors for Antigen. 85: Functions of Natural Killer Cells. 86: Classification and Clinical Manifestation of Lymphocyte and... 87: Lymphocytosis and Lymphocytopenia. 88: Immunodeficiency Diseases. 89: Acquired Immunodeficiency Syndrome (AIDS). 90: Mononucleosis Syndromes. Part IX: Malignant Diseases. 91: Classification of Myeloid Malignancies. 92: Myelodysplastic Disorders. 93: Acute Myelogenous Leukemia. 94: Chronic Myelogenous Leukemia and Related Disorders. 95: Idiopathic Myelofibrosis (Agnogenic Myeloid Metaplasia). 96: Classification of Malignant Lymphoid Disorders. 97: Acute Lymphocytic Leukemia. 98: Chronic Lymphocytic Leukemia and Related Diseases. 99: Hairy Cell Leukemia. 100: Large Granular Lymphocytic Leukemia. 101: Pathology of Malignant Lymphomas. 102: Hodgkin Disease. 103: Lymphomas. 104: Plasma Cell Neoplasms: General Considerations. 105: Essential Monoclonal Gammopathy. 106: Plasma Cell Myeloma. 107: Amyloidosis. 108: Macroglobulinemia. 109: Heavy- Chain Disease. Part X: Hemostatasis and Thrombosis. 110: Megakaryopoiesis and Thrombopoiesis. 111: Platelet Morphology, Biochemistry and Function. 112: Molecular Biology, Biochemistry and Life- Span of Plasma... The Pathway of Blood Coagulation. 113: Control of Coagulation Reactions. 114: Vascular Function in Hemostasis. 115: Evaluation, Classification and Clinical Manifestations of Disorders of Hemos. 116: Molecular Mechanisms of Fibrinolysis. 117: Thrombocytopenia. 118: Thrombocytosis and Essential Thrombocythemia. 119: Hereditary Qualitative Platelet Disorders. 120: Acquired Qualitative Platelet Disorders Due to Disease, Drugs, and Foods. 121: The Vascular Purpuras. 122: Bleeding Disorders Due to Coagulation Factors II, V, VII, X, XI, XIII and Combined FV and VIII. 123: Hemophilia A and Hemophilia B. 124: Hereditary Abnormalities in Fibrinogen. 125: Coagulopathies Associated With Liver Disease, Liver Transplantation. 126: Disseminated Intravascular Coagulation. 127: The Inherited Thrombophilias. 128: Lupus Anticoagulants and Related Disorders. 129: Venous Thrombosis. 130: Thrombosis, Arteriosclerosis, and Coronary Artery Disease. 131: Antiplatelet Drugs and Therapy. 132: Oral Anticoagulants. 133: Heparin, Hirudin and Related Agents. 134: Fibrinolytic Therapy. 135: Von Willebrand Disease. 136: Disorders of Fibrinolysis and Use of Antifibrinolytic Agents. Part XI: Transfusion Medicine. 137: Erythrocyte Antigens and Antibodies. 138: Human Leukocyte and Platelet Antigens. 139: Blood Procurement and Screening. 140: Preservation and Clinical Use of Erythrocytes and Whole Blood. 141: Collection and Transfusion of Leukocytes, Dendritic Cells, and Stem Cells. 142: Preservation and Clinical Use of Platelets. 143: Preparation and Clinical Use of Plasma and Plasma Fractions. 144: Therapeutic Hemapheresis: Indications, Efficacy, Complications.