Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition

Ph.D., R.Ph.President, Applied Biopharmaceutics, LLC, Raleigh, NCAffiliate Professor, School of Pharmacy, Virginia Commonwealth University, Richmond VAAdjunct Associate Professor, School of Pharmacy, University of Maryland, Baltimore, MD McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide Andy Yu, formerly a professor at the Albany College of Pharmacy, is currently with the FDA in Rockville, MD.

PrefaceGlossaryChapter 1 Introduction to Biopharmaceutics and Pharmacokinetics Chapter 2 Mathematic Fundamentals in Pharmacokinetics Chapter 3One Compartment Open Model – IV Bolus Injection Chapter 4Multicompartmental Models – IV Bolus InjectionChapter 5Intravenous InfusionChapter 6Drug Elimination and ClearanceChapter 7Pharmacokinetics of Oral AbsorptionChapter 8 Multiple Dosage RegimensChapter 9 Nonlinear PharmacokineticsChapter 10 Physiologic Drug Distribution and Protein BindingChapter 11 Renal and Hepatic Elimination of Drugs Chapter 12Pharmacogenetics - NEW Chapter 13Physiologic Factors Related to Drug AbsorptionChapter 14Biopharmaceutic Considerations in Drug Product DesignChapter 15Bioavailability and Bioequivalence Chapter 16 Impact of Biopharmaceutics on Drug Product Quality and Clinical Efficacy - NEW Chapter 17Modified Release Drug Products and Drug DevicesChapter 18Targeted Drug Delivery Systems and Biotechnology ProductsChapter 19Relationship between Pharmacokinetic and Pharmacodynamics Chapter 20Application of Pharmacokinetics in Clinical SituationsChapter 21 Dosage Adjustment in Renal and Hepatic Disease Chapter 22 Physiological Pharmacokinetic Models, Mean Resident Time and Statistical Moment TheoryAppendix AStatisticsAppendix BApplications of Computers in PharmacokineticsAppendix CEthical ConsiderationsAppendix DSolutions to Frequently Asked Questions (FAQ) and Learning QuestionsAppendix EPopular Drugs and Pharmacokinetic Parameters