Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition - Leon Shargel, Andrew Yu, Susanna Wu-Pong

Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition

Buch | Hardcover
832 Seiten
2012 | 6th edition
McGraw-Hill Medical (Verlag)
978-0-07-160393-5 (ISBN)
73,55 inkl. MwSt
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A textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics. It provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy.
A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics The field’s leading text for more than three decades

Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy.

Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to:

Understand the basic concepts in biopharmaceutics and pharmacokinetics.Use raw data and derive the pharmacokinetic models and parameters that bestdescribe the process of drug absorption, distribution, and eliminationCritically evaluate biopharmaceutic studies involving drug product equivalencyand unequivalencyDesign and evaluate dosage regimens of drugs, using pharmacokinetic andbiopharmaceutic parametersDetect potential clinical pharmacokinetic problems and apply basic pharmacokineticprinciples to solve them
Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.

Ph.D., R.Ph.President, Applied Biopharmaceutics, LLC, Raleigh, NCAffiliate Professor, School of Pharmacy, Virginia Commonwealth University, Richmond VAAdjunct Associate Professor, School of Pharmacy, University of Maryland, Baltimore, MD Andy Yu, formerly a professor at the Albany College of Pharmacy, is currently with the FDA in Rockville, MD. McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide

Preface

Glossary

1. Intrtoduction to Biopharmaceutics and Pharmacokinetics

2. Mathematical Fundamentals in Pharmacokinetics

3. One-compartment Open Model: Intravenous Bolus Administration 5. Intravenous Infusion

6. Drug Elimination and clearance

7. Pharmacokinetics of Oral Absorption

8. Multiple-Dosage Regimens

9. Monlinear Pharmacokinetics

10. Physiologic Drub Distribution and Protein Binding

11. Drug Elimination and Hepatic Clearance

12. Pharmacogenetics

13. Physioloic Factors Related to Drug Absorption

14. Biopharmaceutc Consideratins in Drug Product Desitgn and In Vitro Drug Product Performance

15. Drug Product Performance, In Vivo: Bioavailability and Bioequivalence

16. Impact of Drug Product Quality and Biopharmaceutics on Clincal Efficacy

17. Modified-Release Drug Products

18. Targeted Drug Delivery Symptoms and Biotechnological Products

19. Relationship Between Pharmacokeinetics and Pharmacodynamics

20. Application of Pharmacokinetics to Clinical Situations

21. Dose Adjustment in Renal and Hepatic Disease Appendix A Statistics

Appendix B Applications of Computer in Pharmacokinetcs

Appendix C Solutions to Frequently Asked Questions (FAQs) and Learning Questions

Appendix D Guiding Prinicples for Human and Animal Research

Appendix E Popular Drugs and Pharmacokinetic Parameters

Index

Erscheint lt. Verlag 16.4.2012
Verlagsort New York
Sprache englisch
Maße 191 x 239 mm
Gewicht 1364 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pflege
Medizin / Pharmazie Pharmazie PTA / PKA
ISBN-10 0-07-160393-X / 007160393X
ISBN-13 978-0-07-160393-5 / 9780071603935
Zustand Neuware
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