New Rapid-acting Antidepressants

First Name – Kenji Last Name – Hashimoto Institution - Chiba University Center for Forensic Mental Health Department - Division of Clinical Neuroscience City – Chiba 260-8670 State – Chiba Country – Japan Email – hashimoto@faculty.chiba-u.jp Kenji Hashimoto, PhD Chiba University, Chiba, Japan Dr. Hashimoto is a professor and vice-director of Chiba University Center for Forensic Mental Health from 2005. Dr. Hashimoto graduated from Faculty of Pharmaceutical Sciences at Kyushu University, and received PhD. After Dr. Hashimoto worked at Fukuyama University, National Institutes of Health (NIH)/National Institute of Drug Addiction (NIDA)(Baltimore, MD, USA) and Pharmaceutical company, he moved at Chiba University Graduate School of Medicine from 2001. Dr. Hashimoto works on the development of novel therapeutic drugs for psychiatric and neurological disorders. Dr. Hashimoto published more than 550 articles in PubMed listed publications. Dr. Hashimoto focus on the molecular and cellular mechanisms of ketamine’s antidepressant actions.

(R)-ketamine: A new rapid-acting antidepressant.- (2R,6R)-hydroxynorketamine, a metabolite of ketamine: the antidepressant actions and the mechanisms.- Predictable biomarkers for rapid-acting antidepressant response to ketamine.- Nitrous Oxide: an old compound with emerging psychotropic properties.- Novel AMPA receptor potentiators TAK-137 and TAK-653 as potential rapid-acting antidepressants.- AMPA receptor potentiators as potential rapid-acting antidepressants.- mGlu2/3 receptor antagonists as rapid-acting antidepressants.- Antidepressant effects of the muscarinic receptor antagonist scopolamine: Clinical and preclinical review.