Genetic Predisposition to Cancer, 2Ed
Hodder Arnold (Verlag)
978-0-340-76254-7 (ISBN)
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Over the last 20 years it has become increasingly apparent that the occurrence of many cancers can have an inherited basis. This book examines the principles underlying genetic predisposition to cancer and will be relevant to practising oncologists, geneticists and other professionals interested in this rapidly expanding field. Coverage is comprehensive, taking the reader from an introduction to genetic predisposition, through a discussion of the molecular biology and statistical techniques involved in the identification and characterisation of predisposition genes, to a consideration of heritable cancer syndromes, and encompasses both rare and common cancers. The text also features a discussion of cancer risk assessment, genetic counselling issues, genetic screening and cancer management options, and a consideration of the associated ethical and psychological issues.
Building on the reputation of the previous edition, and to reflect the rapid advances in the field since its publication, the contents of the second edition have been thoroughly updated and include discussion of many newly identified cancer genes. In particular, the book features new chapters added on the biological basis of cancer predisposition, population-based studies of susceptibility, and evaluation of management strategies for individuals at increased cancer risk.
Rosalind A. Eeles is Clinical Senior Lecturer and Honorary Consultant in Cancer Genetics and Clinical Oncology; Team Leader, Translation Cancer Genetics Team, Institute of Cancer Research; and Head, Cancer Genetics Unit, Royal Marsden NHS Trust, Sutton, UK Douglas F. Easton is Director, Cancer Research UK Genetic Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK Bruce A. J. Ponder is Cancer Research UK Professor of Oncology; Director, Cancer Research UK Human Genetics Research Group; and Co-Director, Hutchison-MRC Research Centre and Strangeways Laboratory for Genetic Epidemiology, University of Cambridge, UK Charis Eng is Dorothy E. Klotz Chair of Cancer Research; William C. and Joan E. Davis Professor of Cancer Research; Professor & Director, Division of Human Genetics, Department of Internal Medicine; and Director, Clinical Cancer Genetics Program, The Ohio State University, Columbus, Ohio, USA
Part One: Basic Principles
1. Genetic predisposition to cancer: an introduction
2. Biological basis of cancer predisposition
3. From families to chromosomes: genetic linkage and association studies for finding cancer–predisposition genes
4. From chromosomes to genes: how to isolate cancer-predisposition genes
5. Screening for mutations in cancer predisposition genes
Part Two: Inherited Cancer Syndromes
6. Retinoblastoma: the paradigm for a genetically inherited cancer syndrome
7. Neurofibromatosis types 1 and 2
8. Multiple endocrine neoplasia type 2
9. Wilms tumour and other childhood renal tumours
10. Genetic susceptibility to renal cell carcinoma
11. The Li-Fraumeni syndrome and the role of TP53 mutations in cancer predisposition
12. Cowden syndrome
Part Three: Chromosome Fragility Syndromes and the Gorlin Syndrome
13. Malignant disease and variations in radiosensitivity in ataxia telangiectasia patients
14. Fanconi anaemia
15. The Gorlin (Nevoid basal cell carcinoma) Syndrome
16. Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: sun sensitivity, DNA repair defects and skin cancer
Part Four: The Common Cancers
17. Genetics and the common cancers
18. Familial Breast Cancer
19. The BRCA1 and BRCA2 genes
20. Screening for breast cancer in high-risk populations
21. The controversy of prophylactic mastectomy
22. The role of chemoprevention in the common cancers
23. Familial ovarian cancer
24. Familial colon cancer syndromes and their genetics
25. Screening and management of familial colon cancer
26. Familial prostate cancer and its management
27. Familial melanoma and its management
28. Familial predisposition to lung cancer
29. Genetic susceptibility to carcinoma of the head and neck, stomach, pancreas and the MEN 1 syndrome
Part Five: Psychosocial, Ethical and Organisational Issues
30. The cancer family clinic
31. Psychological issues in cancer genetics
32. Ethical and insurance issues of testing for cancer-predisposition genes
| Erscheint lt. Verlag | 27.8.2004 |
|---|---|
| Zusatzinfo | 60 b/w & 20 col illus |
| Verlagsort | London |
| Sprache | englisch |
| Maße | 202 x 270 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| ISBN-10 | 0-340-76254-3 / 0340762543 |
| ISBN-13 | 978-0-340-76254-7 / 9780340762547 |
| Zustand | Neuware |
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