Genetic Predisposition to Cancer

Part One Basic Principles
Genetic predisposition to cancer: an introduction
From families to chromosomes: genetic linkage, and other methods of finding cancer-predisposition genes
From chromosomes to genes: how to isolate cancer predisposition genes.
Part Two
Inherited Cancer Syndromes
Retinoblastoma: the paradigm for a genetically inherited cancer syndrome
Neurofibromatosis - types I and II
Multiple endocrine neoplasia
Wilms tumour and other genetic causes of renal cancer
The Li-Fraumeni syndrome and the role of TP53 mutations in predisposition to cancer.
Part Three
Chromosome Fragility Syndromes and the Gorlin Syndrome
Malignant disease and variations in radiosensitivity ataxia telangiectasia patients
Fanconi's anaemia
The Gorlin (nevoid basal cell carcinoma) syndrome
Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: sun sensitivity, DNA repair defects and skin cancer.
Part Four
The Common Cancers
Genetics and the common cancers
Familial breast cancer
The breast
ovarian cancer syndrome and BrCA1
Screening for breast cancer in high-risk populations
The management of women with a high risk of breast cancer: (1) the role of prophylactic tamoxifen
(2) the controversy of prophylactic mastectomy
Psychological distress associated with genetic breast cancer risk
Familial ovarian cancer
Familial colon cancer syndromes and their clinical management
The genetics of familial colon cancer
Familial prostate cancer and its management
Familial melanoma and its management
Familial predisposition to lung cancer.
Part Five
Health Care Aspects
The cancer family clinic
Screening for mutations in cancer predisposition genes
The ethics of testing for cancer predisposition genes.