Progress in the Chemistry of Organic Natural Products 115
Seiten
2021
|
1st ed. 2021
Springer International Publishing (Verlag)
978-3-030-64852-7 (ISBN)
Springer International Publishing (Verlag)
978-3-030-64852-7 (ISBN)
This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
Total Synthesis of Decanolides (Nonanolides) with a Special Focus on Olefin Metathesis.- From Plant to Patient: Thapsigargin.- Antileishmanial Activity of Lignans and Neolignans.- Cryptolepine as a Lead to new Antiprotozoal Agents.- Biologically Active Constituents from Plants of the Genus Xanthium.
Erscheinungsdatum | 08.04.2021 |
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Reihe/Serie | Progress in the Chemistry of Organic Natural Products |
Zusatzinfo | VII, 203 p. 144 illus., 42 illus. in color. |
Verlagsort | Cham |
Sprache | englisch |
Maße | 155 x 235 mm |
Gewicht | 489 g |
Themenwelt | Medizin / Pharmazie ► Pharmazie |
Naturwissenschaften ► Biologie ► Botanik | |
Naturwissenschaften ► Chemie ► Organische Chemie | |
Schlagworte | Anticancer Drug Development • Bioactive Compounds • cryptolepine • decanolides • Lead compound in drug development • natural product synthesis and isolation • thapsigargin • total synthesis |
ISBN-10 | 3-030-64852-4 / 3030648524 |
ISBN-13 | 978-3-030-64852-7 / 9783030648527 |
Zustand | Neuware |
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