Nanopharmaceutical Advanced Delivery Systems

Vivek Dave gained his PhD in pharmaceutics in 2014 from Banasthali University, Rajasthan. He is an associate professor at the Central University South Bihar, India. His research interests are in formulation and development of novel drug delivery systems like PEGylated liposome, ethosomes. He has published more than 70 research papers and is the recipient of several awards. Srija Sur recently completed her M.PHARM at Banasthali Vidyapith, India, and is now affiliated to the Department of Pharmacy, Banasthali Vidyapith, Rajasthan. Her research specialization is in the field of pharmaceutics. Nikita Gupta recently completed her M.PHARM at Banasthali Vidyapit India, and is now affiliated to the Department of Pharmacy, Banasthali Vidyapith, Rajasthan. Her research specialization is in the field of nanopharmaceutics and nanotechnology.

Preface xxi

Part 1: Introduction to the Fundamentals 1

1 Lipid-Based Nanocarriers as Drug Delivery System and Its Applications 3
Vikas Jain, Hitesh Kumar, Pallavi Chand, Sourabh Jain and Preethi S

2 Nanoparticulate Carriers—Versatile Delivery Systems 31
Ruchi Chawla, Varsha Rani and Mohini Mishra

3 Nanotools in Customized Drug Delivery System 55
Thirumalai Subramaniam K J, Gowthamarajan Kuppusamy, Arun Radhakrishnan and Veera Venkata Satyanarayana Reddy Karri

Part 2: Novel and Modernized Nanoscale Delivery Systems: Revolutionary Progress in the Field of Pharmacy 79

4 Dendrimers: Role in Novel Drug Delivery 81
Pooja Mittal, Ramit Kapoor and Brahmeshwar Mishra

5 Nanofibers in Drug Delivery 99
Dipak Kumar Sahu, Goutam Ghosh and Goutam Rath

6 Microbubbles used for Drug Delivery System 125
Hemraj Heer, Vishav Prabhjot Kaur, Sandeep Rathor, Sheikh Aamir and Charan Singh

7 Virosomes: A Viral Envelope System Having a Promising Application in Vaccination and Drug Delivery System 145
Ankit Kalra and Shilpa Sharma

8 Nanocarriers: A Tool for Effective Gene Delivery 161
Rita N. Wadetwar and Amita P. Godbole

9 Phytosomes—Nanoarchitectures’ Promising Clinical Applications and Therapeutics 187
Pankaj Pal, Vivek Dave, Shailendra Paliwal, Monika Sharma, Mrugendra B. Potdar and Avnica Tyagi

10 Saponin Stabilized Emulsion as Sustainable Drug Delivery System: Current Status and Future Prospects 217
Priyanka Yatham, Yogita Dahat, Arshad Khan, Rinku Baishya, Amit K. Srivastava and Deepak Kumar

11 Mono and Multi-Stimuli Responsive Polymers: Application as Intelligent Nano-Drug Delivery Systems 237
Archana Sidagouda Patil, Anand Panchakshari Gadad and Panchaxari Mallappa Dandagi

12 An Insight into Nanosomes: Potential Nanopharmaceutical Delivery System 267
Trishna Bal, Sandeep Garg, Aditya Dev Rajora, Shubha Rani Sharma and Harshita Harsh

13 Nano-Structures as Bioelectronics for Controlled Drug Delivery 285
Debabrata Ghosh Dastidar, Dipanjan Ghosh and Gopal Chakrabarti

14 Bioadhesive Nanoparticulate Drug Delivery System 309
Rajashree Shashidhar Masareddy, Archana Sidagouda Patil and Anand Panchakshari Gadad

Part 3: Understanding Targeted Delivery Systems 333

15 Nanopharmaceuticals: An Approach for Effective Management of Breast Cancer 335
Veena S. Belgamwar, Suchitra S. Mishra, Vidyadevi T. Bhoyar and Kunal B. Banode

16 Vaginal Nano-Based Drug Delivery System 357
Rita N. Wadetwar and Pranita S. Kanojiya

17 Recent Advances in Polymer-Modified Liposomes for Cancer Treatment 379
Swapnil Sharma, Akansha Bisht, Sanjana Tewari and Vivek Dave

18 Role of Nanomedicines in Neglected Tropical Diseases 407
Rahul Shukla, Atul Mourya, Mayank Handa and Rewati Raman Ujjwal

Part 4: Overview of Regulatory Affairs 447

19 Current Framework, Ethical Consideration and Future Challenges of Regulatory Approach for Nano-Based Products 449
Vivek Dave, Srija Sur and Nikita Gupta

Index 473