Childhood Leukemias

Date of birth 20/8/1951

Part I. History and General Issues: 1. Historical perspective Donald Pinkel; 2. Diagnosis and classification Mihaela Onciu and Ching-Hon Pui; 3. Epidemiology and etiology Logan Spector, Julie A. Ross, Leslie L. Robison and Smita Bhatia; Part II. Cell Biology and Pathology: 4. Anatomy and physiology of hematopoiesis Connie J. Eaves and Allen C. Eaves; 5. Hematopoietic growth factors James N. Ihle; 6. Signal transduction in the regulation of hematopoiesis James N. Ihle; 7. Immunophenotyping Fred G. Behm; 8. Immunoglobulin and T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W. Langerak; 9. Cytogenetics of acute leukemias Susana C. Raimondi; 10. Molecular genetics of acute lymphoblastic leukemia Adolfo Ferrando, Jeffrey E. Rubnitz and A. Thomas Look; 11. Molecular genetics of acute myeloid leukemia Robert Lorsbach and James R. Downing; 12. Apoptosis and chemoresistance Kirsteen H. MacLean and John L. Cleveland; 13. Heritable predispositions to childhood hematologic malignancies Doan Le, Kevin Shannon and Beverly J. Lange; Part III. Evaluation and Treatment: 14. Pharmacokinetics, pharmacodynamics and pharmacogenetic considerations Shinji Kishi, Williams E. Evans and Mary V. Relling; 15. Assays and molecular determinants of cellular drug resistance Monique L. den Boer and Rob Pieters; 16. Acute lymphoblastic leukemia Ching-Hon Pui; 17. Relapsed acute lymphoblastic leukemia Günter Henze and Arend von Stackelberg; 18. B-cell acute lymphoblastic leukemia and Burkitt lymphoma John T. Sandlund and Ian T. Magrath; 19. Acute myeloid leukemia Jeffrey E. Rubnitz, Bassem Razzouk and Raul Ribeiro; 20. Relapsed acute myeloid leukemia Ursula Creutzig; 21. Myelodysplastic syndromes Henrik Hasle; 22. Chronic myeloproliferative disorders Charlotte M. Niemeyer and Franco Locatelli; 23. Hematopoietic stem cell transplantation Rupert Handgretinger, Victoria Turner and Raymond Barfield; 24. Acute leukemia in countries with limited resources Raul Ribeiro, Scott Howard and Ching-Hon Pui; 25. Antibody-targeted therapy Eric L. Sievers and Irwin D. Bernstein; 26. Adoptive cellular immunotherapy Helen E. Heslop and Cliona M. Rooney; 27. Gene therapy: methods and applications Martin Pulè and Malcolm K. Brenner; 28. Minimal residual disease Dario Campana, Andrea Biondi and Jacques J. M. van Dongen; Part IV. Complications and Supportive Care: 29. Acute complications Scott C. Howard, Raul C. Ribeiro and Ching-Hon Pui; 30. Late complications after leukemia therapy Melissa Hudson; 31. Therapy-related leukemias Carolyn A. Felix; 32. Infectious disease complications in leukemia Jeremy A. Franklin and Patricia M. Flynn; 33. Hematologic supportive care Fariba Navid and Victor M. Santana; 34. Pain management Alberto de Armendi and Doraline L. Anghelescu; 35. Psychosocial issues Raymond K. Mulhern, Sean Phipps and Vida L. Tyc; 36. Nursing care Pamela S. Hinds, Jami S. Gattuso and Belinda N. Mandrell.