Biomedical Applications of Acridines - Jan Ježek, Jan Hlaváček, Jaroslav Šebestík

Biomedical Applications of Acridines

Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases
Buch | Softcover
XIII, 237 Seiten
2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-87680-1 (ISBN)
149,79 inkl. MwSt

This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.

 

Preliminary ToC 1 Introduction.- 2 Nomenclature.- 3. Syntheses.- 4. Interactions of acridines with nucleic acids.- 5. Intercations with proteins.- 6. Applications for treament of neurodegenerative diseases.- 7. Some applications of selective toxicities of acridines.- 8. Acridine on dendrimeric carriers.- 9 Acridines used for staining.- 10 Miscellaneous.- 11 Conclusions and outlook.

Erscheint lt. Verlag 11.8.2018
Reihe/Serie Progress in Drug Research
Zusatzinfo XIII, 237 p. 79 illus., 25 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 391 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Biomedizin
Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Chemie Physikalische Chemie
Schlagworte acridine-nucleic acid interactions • acridine-protein interactions • acridines • Labeling • neurodegenerative diseases • Protein-Ligand Interactions
ISBN-10 3-319-87680-5 / 3319876805
ISBN-13 978-3-319-87680-1 / 9783319876801
Zustand Neuware
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