Pathology of the Placenta (eBook)

Dr. T. Yee Khong, MBChB, MD, MSc, FRCPath, FRCPA, FAMM, GAICD, is a Consultant Pathologist at SA Pathology, Women’s and Children’s Hospital, Adelaide, Australia. He qualified in medicine from University of Sheffield, UK and did his pathology training at St George’s Hospital Medical School, London and John Radcliffe Hospital, Oxford, UK. He is Professor of Pathology and Obstetrics & Gynaecology, at the University of Adelaide and a former President of the Royal College of Pathologists of Australasia.Dr. Eoghan Mooney, MBChB, MRCPI, FRCPath, FFPath (RCPI), was born in Dublin, Ireland, where he now lives and works. He is a graduate of the National University of Ireland (University College Dublin). Following pathology training in Dublin and in Duke University, North Carolina, USA he completed his Fellowship in Gynaecologic and Breast pathology in the Armed Forces Institute of Pathology, Washington DC. He has been a consultant pathologist for 17 years, based in the National Maternity Hospital and St Vincent’s University Hospital and has published in the area of placental pathology for 20years.Dr. Peter G.J. Nikkels, MD, PhD, is a staff member in the Department of Pathology, University Hospital Utrecht, the Netherlands. He qualified in medicine from Erasmus University Rotterdam, the Netherlands and did his pathology training at the Department of Pathology, University Hospital Groningen, the Netherlands where he became a consultant pathologist. He has published extensively in placental pathology.Dr. Terry K. Morgan, MD, PhD, completed residency training, a surgical pathology fellowship and cytopathology fellowship at Stanford University Medical Center. He is Associate Professor of Pathology and Obstetrics & Gynecology, at the Oregon Health & Science University. He is the director of placental pathology and the focus of his research laboratory is to determine how abnormal blood flow to the placenta leads to common maternal pregnancy complications and fetal programming of adult onset disease in theirprogeny.Dr. Sanne J Gordijn, MD, PhD, completed her residency training inUniversity of Groningen, the Netherlands and is a consultant in obstetrics witha special interest in perinatology. Her research interests are in perinatalautopsy, placental pathology and classification of perinatal mortality.

Section 1. Background

Chapter 1.      Introduction. An approach to placental pathology

Chapter 2.      Placental Development with Expected Normal Gross and Microscopic Findings

Chapter 3.      Indications for examining the placenta

 

Section 2. Gross examination
Chapter 4.      Gross examination

Chapter 5.      Placental Weight, Shape, and Gross Vascular Morphology

 

Section 3. Placental disc: Macroscopically Visible Lesions

Chapter 6.      Infarction

Chapter 7.      Intervillous thrombosis

Chapter 8.      Massive perivillous fibrin deposition, maternal floor infarct

Chapter 9.      Retroplacental haemorrhage, marginal haemorrhage

Chapter 10.    Fetal Vascular Thrombosis

Chapter 11.    Extravillous trophoblast cyst

 

Section 4.   Placental disc: Microscopic Lesions

Chapter 12.    Acute Chorioamnionitis

Chapter 13.    Chorionic plate chronic inflammatory lesions including eosinophilic/T-cell chorionic vasculitis

Chapter 14.    Maturity anomalies

Chapter 15.    Distal villous hypoplasia

Chapter 16.    Placental mesenchymal dysplasia

Chapter 17.    Increased syncytial knot formation

Chapter 18.    Persistence of cytotrophoblast

Chapter 19.    Mineralization of trophoblast basement membrane

Chapter 20.    Trophoblast and stroma:  vacuolation – inherited disorder of metabolism

Chapter 21.    Villous oedema

Chapter 22.    Extramedullary haemopoiesis

Chapter 23.    Intravillous haemorrhage

Chapter 24.    Hypervascularity      

Chapter 25.    Fetal vascular malperfusion

Chapter 26.    Presence of nucleated red blood cells

Chapter 27.    Fetal vessels: malignancy

Chapter 28.    Acute villitis

Chapter 29.    Chronic villitis

Chapter 30.    Chronic histiocytic intervillositis

Chapter 31.    Intervillous space:  infiltrates

Chapter 32.    Pregnancy-induced uterine vascular remodelling and the pathophysiology of decidual vasculopathy

Chapter 33.    Chronic deciduitis

Chapter 34.    Basal plate myometrial fibres

Chapter 35.    Basal plate laminar necrosis

Chapter 36.    Retroplacental Haematoma/Haemorrhage (RPH)

Chapter 37.    Miscellaneous Lesions of the Villous Parenchyma           

 

Section 5. Amniochorial membranes: Macroscopically Visible Lesions

Chapter 38.    Amniochorial membrane nodules

Chapter 39.    Placental changes in amniotic band sequence, extra-amniotic and extramembranous pregnancy

 

Section 6.   Amniochorial membranes: Microscopic Lesions

Chapter 40.    Amnion Transport: Histologic Features

Chapter 41.    Choriodecidual haemosiderin staining

Chapter 42.    Laminar necrosis; membrane chorionic microcysts and chorion nodosum

Chapter 43.    Decidual Vasculopathy

Chapter 44.    Acute inflammation

Chapter 45.   Chronic inflammation

                       

Section 7. Umbilical cord

Chapter 46.    Umbilical Cord Length

Chapter 47.    Umbilical Cord coiling

Chapter 48.    Cord knots and pseudo-knots

Chapter 49.    Umbilical cord tumours

Chapter 50.    Umbilical Cord Insertion abnormalities

Chapter 51.    Embryonic remnants and pathology

Chapter 52.    Single Umbilical Artery, Supernumerary Vessels, Segmental Thinning of the Umbilical Cord Vessels and Vascular calcifications in umbilical vessels

Chapter 53.    Umbilical cord ulcer

Chapter 54.    Umbilical vascular myonecrosis

Chapter 55.    Inflammation

                       

Section 8. Clinical correlation, reporting and frontiers

Chapter 56.    Constellations of Pathology in the Placenta and How They Relate to Clinical Conditions.

Chapter 57.    The Placental Pathology Report

Chapter 58.    Frontiers