Harrisons Manual of Medicine

Dennis L. Kasper, MD, MA (Hon)William Ellery Channing Professor of MedicineProfessor of Microbiology and Molecular GeneticsExecutive Dean for Academic ProgramsHarvard Medical SchoolDirector, Channing LaboratoryDepartment of MedicineBrigham and Women’s Hospital Anthony S. Fauci, MDChief, Laboratory of ImmunoregulationDirector, National Institute of Allergy and Infectious DiseasesNational Institutes of Health. In 2008, Dr. Fauci was awarded the Presidential Medal of Freedom, the Nation's highest civil award. Stephen L. Hauser, MDChairman and Betty Anker Fife ProfessorDepartment of NeurologyUniversity of California, San Francisco Dan L. Longo, MDScientific DirectorNational Institute on AgingNational Institutes of HealthBethesda, Maryland C.F. Kettering Professor of Medicine, Chief, Division of Endocrinology, Metabolism and Molecular Medicine Northwestern University Medical School, Chicago, IL. Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine; Physician-in-Chief, Brigham and Women’s Hospital, Boston, Massachusetts

Contributors
Preface
Acknowledgments
SECTION 1 Care of the Hospitalized Patient
1 Electrolytes
2 Acid-Base Disorders
3 Diagnostic Imaging in Internal Medicine
4 Procedures Commonly Performed by Internists
5 Principles of Critical Care Medicine
6 Pain and Its Management
7 Assessment of Nutritional Status
8 Enteral and Parenteral Nutrition
9 Transfusion and Pheresis Therapy
10 Palliative and End-of-Life Care
SECTION 2 Medical Emergencies
11 Cardiovascular Collapse and Sudden Death
12 Shock
13 Narcotic Overdose
14 Sepsis and Septic Shock
15 Acute Pulmonary Edema
16 Acute Respiratory Distress Syndrome
17 Respiratory Failure
18 Confusion, Stupor, and Coma
19 Stroke
20 Subarachnoid Hemorrhage
21 Increased Intracranial Pressure and Head Trauma
22 Spinal Cord Compression
23 Hypoxic-Ischemic Encephalopathy
24 Status Epilepticus
25 Diabetic Ketoacidosis and Hyperosmolar Coma
26 Hypoglycemia
27 Oncologic Emergencies
28 Anaphylaxis
29 Bites, Venoms, Stings, and Marine Poisonings
SECTION 3 Common Patient Presentations
30 Fever, Hyperthermia, and Rash
31 Generalized Fatigue
32 Unintentional Weight Loss
33 Chest Pain
34 Palpitations
35 Dyspnea
36 Cyanosis
37 Cough and Hemoptysis
38 Edema
39 Abdominal Pain
40 Nausea, Vomiting, and Indigestion
41 Dysphagia
42 Diarrhea, Malabsorption, and Constipation
43 Gastrointestinal Bleeding
44 Jaundice and Evaluation of Liver Function
45 Ascites
46 Lymphadenopathy and Splenomegaly
47 Anemia and Polycythemia
48 Azotemia and Urinary Abnormalities
49 Pain and Swelling of Joints
50 Back and Neck Pain
51 Headache
52 Syncope
53 Dizziness and Vertigo
54 Acute Visual Loss and Double Vision
55 Weakness and Paralysis
56 Tremor and Movement Disorders
57 Aphasia
58 Sleep Disorders
SECTION 4 Otolaryngology
59 Sore Throat, Earache, and Upper Respiratory Symptoms
SECTION 5 Dermatology
60 General Examination of the Skin
61 Common Skin Conditions
SECTION 6 Hematology and Oncology
62 Examination of Blood Smears and Bone Marrow
63 Red Blood Cell Disorders
64 Leukocytosis and Leukopenia
65 Bleeding and Thrombotic Disorders
66 Myeloid Leukemias, Myelodysplasia, and Myeloproliferative Syndromes
67 Lymphoid Malignancies
68 Skin Cancer
69 Head and Neck Cancer
70 Lung Cancer
71 Breast Cancer
72 Tumors of the Gastrointestinal Tract
73 Genitourinary Tract Cancer
74 Gynecologic Cancer
75 Tumors of the Nervous System
76 Prostate Hyperplasia and Carcinoma
77 Cancer of Unknown Primary Site
78 Paraneoplastic Endocrine Syndromes
79 Neurologic Paraneoplastic Syndromes
SECTION 7 Infectious Diseases
80 Growing Threats in Infectious Disease
81 Infections Acquired in Health Care Facilities
82 Infections in the Immunocompromised Host
83 Infective Endocarditis
84 Intraabdominal Infections
85 Infectious Diarrheas and Bacterial Food Poisoning
86 Sexually Transmitted and Reproductive Tract Infections
87 Infections of the Skin, Soft Tissues, Joints, and Bones
88 Pneumococcal Infections
89 Staphylococcal Infections
90 Streptococcal/Enterococcal Infections, Diphtheria, and Infections Caused by Other Corynebacteria and Related Species
91 Meningococcal and Listerial Infections
92 Infections Caused by Haemophilus, Bordetella, Moraxella, and HACEK Group Organisms
93 Diseases Caused by Gram-Negative Enteric Bacteria and Pseudomonads
94 Infections Caused by Miscellaneous Gram-Negative Bacilli
95 Anaerobic Infections
96 Nocardiosis, Actinomycosis, and Whipple’s Disease
97 Tuberculosis and Other Mycobacterial Infections
98 Lyme Disease and Other Nonsyphilitic Spirochetal Infections
99 Rickettsial Diseases
100 Mycoplasma pneumoniae, Legionella Species, and Chlamydia pneumoniae
101 Chlamydia trachomatis and Chlamydia psittaci
102 Infections with Herpes Simplex Virus, Varicella-Zoster Virus, Cytomegalovirus, Epstein-Barr Virus, and Human Herpesvirus Types 6, 7, and 8
103 Influenza and Other Viral Respiratory Diseases
104 Rubeola, Rubella, Mumps, and Parvovirus Infections
105 Enterovirus Infections
106 Insect- and Animal-Borne Viral Infections
107 HIV Infection and AIDS
108 Pneumocystis Pneumonia, Candidiasis, and Other Fungal Infections
109 Overview of Parasitic Infections
110 Malaria, Toxoplasmosis, Babesiosis, and Other Protozoal Infections
111 Helminthic Infections and Ectoparasite Infestations
SECTION 8 Cardiology
112 Physical Examination of the Heart
113 Electrocardiography
114 Noninvasive Examination of the Heart
115 Congenital Heart Disease in the Adult
116 Valvular Heart Disease
117 Cardiomyopathies and Myocarditis
118 Pericardial Disease
119 Hypertension
120 Metabolic Syndrome
121 ST-Segment Elevation Myocardial Infarction
122 Unstable Angina and Non-ST-Elevation Myocardial Infarction
123 Chronic Stable Angina
124 Bradyarrhythmias
125 Tachyarrhythmias
126 Heart Failure and Cor Pulmonale
127 Diseases of the Aorta
128 Peripheral Vascular Disease
129 Pulmonary Hypertension
SECTION 9 Pulmonology
130 Diagnostic Procedures in Respiratory Disease
131 Asthma
132 Environmental Lung Diseases
133 Chronic Obstructive Pulmonary Disease
134 Pneumonia, Bronchiectasis, and Lung Abscess
135 Pulmonary Thromboembolism and Deep-Vein Thrombosis
136 Interstitial Lung Disease
137 Diseases of the Pleura
138 Diseases of the Mediastinum
139 Disorders of Ventilation
140 Sleep Apnea
SECTION 10 Nephrology
141 Acute Renal Failure
142 Chronic Kidney Disease and Uremia
143 Dialysis
144 Renal Transplantation
145 Glomerular Diseases
146 Renal Tubular Disease
147 Dysuria, Urinary Tract Infections, Bladder Pain, and Interstitial Cystitis
148 Nephrolithiasis
149 Urinary Tract Obstruction
SECTION 11 Gastroenterology
150 Peptic Ulcer and Related Disorders
151 Inflammatory Bowel Diseases
152 Colonic and Anorectal Diseases
153 Cholelithiasis, Cholecystitis, and Cholangitis
154 Pancreatitis
155 Acute Hepatitis
156 Chronic Hepatitis
157 Cirrhosis and Alcoholic Liver Disease
158 Portal Hypertension
SECTION 12 Allergy, Clinical Immunology, and Rheumatology
159 Diseases of Immediate-Type Hypersensitivity
160 Primary Immune Deficiency Diseases
161 Systemic Lupus Erythematosus
162 Rheumatoid Arthritis
163 The Spondyloarthritides
164 Other Connective Tissue Diseases
165 Vasculitis
166 Osteoarthritis
167 Gout, Pseudogout, and Related Diseases
168 Other Musculoskeletal Disorders
169 Sarcoidosis
170 Amyloidosis
SECTION 13 Endocrinology and Metabolism
171 Disorders of the Anterior Pituitary and Hypothalamus
172 Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone
173 Thyroid Gland Disorders
174 Adrenal Gland Disorders
175 Obesity
176 Diabetes Mellitus
177 Disorders of the Male Reproductive System
178 Disorders of the Female Reproductive System
179 Hypercalcemia and Hypocalcemia
180 Osteoporosis and Osteomalacia
181 Hypercholesterolemia and Hypertriglyceridemia
182 Hemochromatosis, Porphyrias, and Wilson’s Disease
SECTION 14 Neurology
183 The Neurologic Examination
184 Seizures and Epilepsy
185 Alzheimer’s Disease and Other Dementias
186 Parkinson’s Disease
187 Ataxic Disorders
188 ALS and Other Motor Neuron Diseases
189 Autonomic Nervous System Disorders
190 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders
191 Spinal Cord Diseases
192 Multiple Sclerosis
193 Neuromyelitis Optica
194 Acute Meningitis and Encephalitis
195 Chronic and Recurrent Meningitis
196 Peripheral Neuropathies, Including Guillain-Barré Syndrome
197 Myasthenia Gravis
198 Muscle Diseases
SECTION 15 Psychiatry and Substance Abuse
199 Psychiatric Disorders
200 Psychiatric Medications
201 Eating Disorders
202 Alcohol Use Disorder
203 Narcotic Abuse
204 Cocaine and Other Commonly Used Drugs
SECTION 16 Disease Prevention and Health Maintenance
205 Routine Disease Screening
206 Vaccines
207 Cardiovascular Disease Prevention
208 Prevention and Early Detection of Cancer
209 Smoking Cessation
210 Women’s Health
SECTION 17 Adverse Drug Reactions
211 Adverse Drug Reactions
Index