Harrisons Manual of Medicine

Dennis L. Kasper MD, MA(HON) William Ellery Channing Professor of Medicine, Professor of Microbiology and Molecular Genetics, Harvard Medical School; Director, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts

Anthony S. Fauci, MD Sc(HON) Chief Laboratory of Immunoregulation: Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

Stephen L. Hauser, MD Robert A. Fishman, Distinguished Professor and Chairman, Department of Neurology, University of California ,San Francisco, San Francisco, California

Dan L. Longo, MD Professor of Medicine, Harvard Medical School; Senior Physician, Brigham and Women's Hospital; Deputy Editor, New England Journal of Medicine, Boston, Massachusetts; Adjunct Investigator, National Institute on Aging, National Institutes of Health, Bethesda, Maryland

J. Larry Jameson, MD, PhD Robert G. Dunlop Professor of Medicine; Dean, University of Pennsylvania Perelman School of Medicine, Executive Vice-President, University of Pennsylvania Health System, Philadelphia, Pennsylvania

Joseph Loscalzo, MD, PhD Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine; Physician-in-Chief, Brigham and Woman's Hospital, Boston, Massachusetts

Section 1: Care of the Hospitalized Patient



1 Electrolytes/Acid-Base Balance

2 Diagnostic Imaging in Internal Medicine

3 Procedures Commonly Performed by Internists

4 Principles of Critical Care Medicine

5 Pain and Its Management

6 Assessment of Nutritional Status

7 Enteral and Parenteral Nutrition

8 Transfusion and Pheresis Therapy

9 Palliative and End-of-Life Care



Section 2: Medical Emergencies



10 Cardiovascular Collapse and Sudden Death

11 Shock

12 Sepsis and Septic Shock

13 Acute Pulmonary Edema

14 Acute Respiratory Distress Syndrome

15 Respiratory Failure

16 Confusion, Stupor, and Coma

17 Stroke

18 Subarachnoid Hemorrhage

19 Increased Intracranial Pressure and Head Trauma

20 Spinal Cord Compression

21 Hypoxic-Ischemic Encephalopathy

22 Status Epilepticus

23 Diabetic Ketoacidosis and Hyperosmolar Coma

24 Hypoglycemia

25 Oncologic Emergencies

26 Anaphylaxis

27 Bites, Venoms, Stings, and Marine Poisonings



Section 3: Common Patient Presentations



28 Fever, Hyperthermia, and Rash

29 Generalized Fatigue

30 Weight Loss

31 Chest Pain

32 Palpitations

33 Dyspnea

34 Cyanosis

35 Cough and Hemoptysis

36 Edema

37 Abdominal Pain

38 Nausea, Vomiting, and Indigestion

39 Dysphagia

40 Diarrhea, Malabsorption, and Constipation

41 Gastrointestinal Bleeding

42 Jaundice and Evaluation of Liver Function

43 Ascites

44 Lymphadenopathy and Splenomegaly

45 Anemia and Polycythemia

46 Azotemia and Urinary Abnormalities

47 Pain and Swelling of Joints

48 Back and Neck Pain

49 Headache

50 Syncope

51 Dizziness and Vertigo

52 Acute Visual Loss and Double Vision

53 Weakness and Paralysis

54 Tremor and Movement Disorders

55 Aphasia

56 Sleep Disorders

57 Dysuria and Bladder Pain



Section 4: Otolaryngology



58 Sinusitis, Pharyngitis, Otitis, and Other Upper Respiratory Tract Infections



Section 5: Dermatology



59 General Examination of the Skin

60 Common Skin Conditions



Section 6: Hematology and Oncology



61 Examination of Blood Smears and Bone Marrow

62 Red Blood Cell Disorders

63 Leukocytosis and Leukopenia

64 Bleeding and Thrombotic Disorders

65 Myeloid Leukemias, Myelodysplasia, and Myeloproliferative Syndromes

66 Lymphoid Malignancies

67 Skin Cancer

68 Head and Neck Cancer

69 Lung Cancer

70 Breast Cancer

71 Tumors of the Gastrointestinal Tract

72 Genitourinary Tract Cancer

73 Gynecologic Cancer

74 Prostate Hyperplasia and Carcinoma

75 Cancer of Unknown Primary Site

76 Paraneoplastic Endocrine Syndromes

77 Neurologic Paraneoplastic Syndromes



Section 7: Infectious Diseases



78 Infections Acquired in Health Care Facilities

79 Infections in the Immunocompromised Host

80 Infective Endocarditis

81 Intraabdominal Infections

82 Infectious Diarrheas

83 Sexually Transmitted and Reproductive Tract Infections

84 Infections of the Skin, Soft Tissues, Joints, and Bones

85 Pneumococcal Infections

86 Staphylococcal Infections

87 Streptococcal/Enterococcal Infections, Diphtheria, and Infections Caused by Other Corynebacteria and Related Species

88 Meningococcal and Listerial Infections

89 Infections Caused by Haemophilus, Bordetella, Moraxella, and HACEK Group Organisms

90 Diseases Caused by Gram-Negative Enteric Bacteria and Pseudomonas

91 Infections Caused by Miscellaneous Gram-Negative Bacilli

92 Anaerobic Infections

93 Nocardiosis, Actinomycosis, and Whipple's Disease

94 Tuberculosis and Other Mycobacterial Infections

95 Lyme Disease and Other Nonsyphilitic Spirochetal Infections

96 Rickettsial Diseases

97 Mycoplasma pneumoniae, Legionella Species, and Chlamydia pneumoniae

98 Chlamydia trachomatis and C. psittaci

99 Herpesvirus Infections

100 Cytomegalovirus and Epstein-Barr Virus Infections

101 Influenza and Other Viral Respiratory Diseases

102 Rubeola, Rubella, Mumps, and Parvovirus Infections

103 Enteroviral Infections

104 Insect- and Animal-Borne Viral Infections

105 HIV Infection and AIDS

106 Fungal Infections

107 Pneumocystis Infections

108 Protozoal Infections

109 Helminthic Infections and Ectoparasite Infestations



Section 8: Cardiology



110 Physical Examination of the Heart

111 Electrocardiography

112 Noninvasive Examination of the Heart

113 Congenital Heart Disease in the Adult

114 Valvular Heart Disease

115 Cardiomyopathies and Myocarditis

116 Pericardial Disease

117 Hypertension

118 Metabolic Syndrome

119 ST-Segment Elevation Myocardial Infarction (STEMI)

120 Unstable Angina and Non-ST-Elevation Myocardial Infarction

121 Chronic Stable Angina

122 Bradyarrhythmias

123 Tachyarrhythmias

124 Heart Failure and Cor Pulmonale

125 Diseases of the Aorta

126 Peripheral Vascular Disease

127 Pulmonary Hypertension



Section 9: Pulmonology



128 Respiratory Function and Pulmonary Diagnostic Procedures

129 Asthma

130 Environmental Lung Diseases

131 Chronic Obstructive Pulmonary Disease

132 Pneumonia, Bronchiectasis, and Lung Abscess

133 Pulmonary Thromboembolism and Deep-Vein Thrombosis

134 Interstitial Lung Disease

135 Diseases of the Pleura and Mediastinum

136 Disorders of Ventilation

137 Sleep Apnea



Section 10: Nephrology



138 Acute Renal Failure

139 Chronic Kidney Disease and Uremia

140 Dialysis

141 Renal Transplantation

142 Glomerular Diseases

143 Renal Tubular Disease

144 Urinary Tract Infections and Interstitial Cystitis

145 Nephrolithiasis

146 Urinary Tract Obstruction



Section 11: Gastroenterology



147 Peptic Ulcer and Related Disorders

148 Inflammatory Bowel Diseases

149 Colonic and Anorectal Diseases

150 Cholelithiasis, Cholecystitis, and Cholangitis

151 Pancreatitis

152 Acute Hepatitis

153 Chronic Hepatitis

154 Cirrhosis and Alcoholic Liver Disease

155 Portal Hypertension



Section 12: Allergy, Clinical Immunology, and Rheumatology



156 Diseases of Immediate-Type Hypersensitivity

157 Primary Immune Deficiency Diseases

158 SLE, RA, and Other Connective Tissue Diseases

159 Vasculitis

160 Ankylosing Spondylitis

161 Psoriatic Arthritis

162 Reactive Arthritis

163 Osteoarthritis

164 Gout, Pseudogout, and Related Diseases

165 Other Musculoskeletal Disorders

166 Sarcoidosis

167 Amyloidosis



Section 13: Endocrinology and Metabolism



168 Disorders of the Anterior Pituitary and Hypothalamus

169 Diabetes Insipidus and SIADH

170 Thyroid Gland Disorders

171 Adrenal Gland Disorders

172 Obesity

173 Diabetes Mellitus

174 Disorders of the Male Reproductive System

175 Disorders of the Female Reproductive System

176 Hypercalcemia and Hypocalcemia