Principles of Bone Biology

Dr. Bilezikian is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. He belongs to the American Society for Bone and Mineral Research (President 1995-1996), and the International Society of Clinical Densitometry (President, 1999-2001). He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present) and is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). Dr. Bilezikian is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700. Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian College of Physician. He has had 12 patents granted and held eight international visiting appointments in the United Kingdom, United States, and Switzerland. An outstanding contribution to science includes the cloning of parathyroid hormone related protein. Thomas Clemens works at the Johns Hopkins University in the Department of Orthopaedic Surgery, Baltimore, MD, USA Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Director of the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor.Dr. Rosen is a Past President of the American Society of Bone and Mineral Research (ASBMR). He served five years as the First Editor in Chief of the Journal of Clinical Densitometry, the official journal for the International Society of Clinical Densitometry, and currently serves as Associate Editor of the Journal of Bone and Mineral Research. His publications exceed 270 manuscripts published in a wide spectrum of clinical and basic science journals.

Volume 1 Part I: Basic principles Section A Cell biology 1. Molecular and cellular regulation of intramembranous and endochondral bone formation during embryogenesis 2. Skeletal stem cells: tissue-specific stem/progenitor cells of cartilage, bone, stroma, and marrow adipocytes 3. Bone marrow and the hematopoietic stem cell niche 4. The osteoblast lineage: its actions and communication mechanisms 5. Osteoclasts 6. The osteocyte 7. Transcriptional control of osteoblast differentiation and function 8. Wnt signaling and bone cell activity 9. Vascular and nerve interactions 10. Coupling of bone formation and resorption 11. Modeling and remodeling: the cellular machinery responsible for bone’s material and structural strength during growth, aging, and drug therapy 12. Aging and bone

Section B Biochemistry 13. Type I collagen structure, synthesis, and regulation 14. Collagen cross-linking and bone pathobiology 15. Secreted noncollagenous proteins of bone 16. Bone proteinases 17. Integrins and other cell surface attachment molecules of bone cells 18. Intercellular junctions and cellecell communication in the skeletal system

Section C Bone remodeling and mineral homeostasis 19. Histomorphometric analysis of bone remodeling 20. Phosphorus homeostasis and related disorders 21. Magnesium homeostasis 22. Metal ion toxicity in the skeleton: lead and aluminum 23. Biology of the extracellular calcium-sensing receptor

Section D Endocrine and paracrine regulation of bone 24. Parathyroid hormone molecular biology 25. Paracrine parathyroid hormonee related protein in bone: physiology and pharmacology 26. Cardiovascular actions of parathyroid hormone/parathyroid hormoneerelated protein signaling 27. Parathyroid hormone and parathyroid hormoneerelated protein actions on bone and kidney 28. Receptors for parathyroid hormone and parathyroid hormoneerelated protein 29. Structure and function of the vitamin D-binding proteins 30. Vitamin D gene regulation 31. Nonskeletal effects of vitamin D: current status and potential paths forward 32. Cellular actions of parathyroid hormone on bone 33. Calcitonin peptides 34. Regulation of bone remodeling by central and peripheral nervous signals

Section E Other systemic hormones that influence bone metabolism 35. Estrogens and progestins 36. Physiological actions of parathyroid hormone-related protein in epidermal, mammary, reproductive, and pancreatic tissues 37. The pharmacology of selective estrogen receptor modulators: past and present 38. Thyroid hormone and bone 39. Basic and clinical aspects of glucocorticoid action in bone 40. Diabetes and bone 41. Androgen receptor expression and steroid action in bone

Section F Local regulators 42. Growth hormone, insulin-like growth factors, and IGF binding proteins

Volume 2 43. The periodontium 44. Notch and its ligands 45. Fibroblast growth factor (FGF) and FGF receptor families in bone 46. Vascular endothelial growth factor and boneevascular interactions 47. Transforming growth factor-b and skeletal homeostasis 48. Bone morphogenetic proteins 49. Extraskeletal effects of RANK ligand 50. Local regulators of bone 51. Prostaglandins and bone metabolism

Part II: Molecular mechanisms of metabolic bone disease 52. The molecular actions of parathyroid hormone/parathyroid hormoneerelated protein receptor type 1 and their implications 53. Multiple endocrine neoplasia type 1 54. Parathyroid hormone-related peptide and other mediators of skeletal manifestations of malignancy 55. Localized osteolysis 56. Genetic regulation of parathyroid gland development 57. Genetic disorders caused by mutations in the parathyroid hormone/parathyroid hormonee related peptide receptor, its ligands, and downstream effector molecules 58. Molecular basis of parathyroid hormone overexpression 59. Diseases resulting from defects in the G protein Gsa 60. Renal osteodystrophy and chronic kidney diseaseemineral bone disorder 61. Osteogenesis imperfecta 62. Hereditary deficiencies in vitamin D action 63. Fibroblast growth factor 23 64. Tumor-induced osteomalacia 65. Osteopetrosis 66. Hypophosphatasia: nature’s window on alkaline phosphatase function in humans 67. Paget’s disease of bone 68. Genetic determinants of bone mass and osteoporotic fracture

Part III: Pharmacological mechanisms of therapeutics 69. Pharmacologic mechanisms of therapeutics: parathyroid hormone 70. Calcium 71. Drugs acting on the calcium receptor: calcimimetics and calcilytics 72. Clinical and translational pharmacology of bisphosphonates 73. Pharmacological mechanisms of therapeutics: receptor activator of nuclear factorekappa B ligand inhibition 74. Pharmacologic basis of sclerostin inhibition 75. Vitamin D and its analogs 76. Mechanisms of exercise effects on bone quantity and quality

Part IV: Methods in bone research 77. Application of genetically modified animals in bone research 78. Bone turnover markers 79. Microimaging 80. Macroimaging 81. Methods in lineage tracing 82. Bone histomorphometry in rodents 83. Bone strength testing in rodents 84. Regulation of energy metabolism by bone-derived hormones