Alagille Syndrome -

Alagille Syndrome

Pathogenesis and Clinical Management
Buch | Hardcover
XIV, 198 Seiten
2018 | 1st ed. 2018
Springer International Publishing (Verlag)
978-3-319-94570-5 (ISBN)
117,69 inkl. MwSt
This text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options.
Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts.  

Binita M. Kamath, MBBChir MRCP MTRThe Hospital for Sick ChildrenDivision of Gastroenterology, Hepatology and Nutrition Toronto, ONCanada Kathleen M. Loomes, MDChildren's Hospital of PhiladelphiaDivision of Gastroenterology, Hepatology and NutritionDepartment of PediatricsPhiladelphia, PAUSA

The Alagille Syndrome: Overview and Introduction.- Bile Duct Development and the Notch Signaling Pathway.- Genetics of Alagille Syndrome.- Liver Disease in Alagille Syndrome.- Transplant Considerations in Alagille Syndrome.- Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille Syndrome.- Vascular Manifestations in Alagille Syndrome.- The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney Development.- Skeletal Involvement in Alagille Syndrome.- Immune Dysregulation in Alagille Syndrome: A Feature of the Evolving Phenotype.- Health-Related Quality of Life and Neurocognition in Alagille Syndrome.- Future Therapeutic Approaches for Alagille Syndrome.

Erscheinungsdatum
Zusatzinfo XIV, 198 p. 41 illus., 31 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 474 g
Themenwelt Medizinische Fachgebiete Chirurgie Viszeralchirurgie
Medizinische Fachgebiete Innere Medizin Gastroenterologie
Medizinische Fachgebiete Innere Medizin Hepatologie
Medizinische Fachgebiete Innere Medizin Kardiologie / Angiologie
Schlagworte bile duct development • complex biliary diseases • hepatology • immune system • notch signaling pathway • Transplant
ISBN-10 3-319-94570-X / 331994570X
ISBN-13 978-3-319-94570-5 / 9783319945705
Zustand Neuware
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