Etiology and Morphogenesis of Congenital Heart Disease (eBook)

Part
I. From Molecular Mechanism to Intervention for Congenital Heart Diseases, Now
and Future .- Reprogramming Approaches to
Cardiovascular Disease: From Developmental Biology to Regenerative Medicine.- The arterial epicardium, a developmental approach to cardiac disease
and repair.- Cell sheet tissue engineering for heart failure.- Future treatment of heart failure and pathophysiological analysis of
various heart diseases using human iPS cell-derived cardiomyocytes.- Congenital heart disease: in search of remedial etiologies.- Part II. Left-Right Axis and
Heterotaxy Syndrome.- Left-right
Asymmetry and Human Heterotaxy Syndrome.- Roles of motile
and immotile cilia in left-right symmetry breaking.- Role of cilia
and left-right patterning in congenital heart disease.- Pulmonary
arterial hypertension in patients with heterotaxy /polysplenia syndrome.- Part III. Cardiomyocyte and Myocardial
Development.- Single Cell Expression Analyses of
Embryonic Cardiac Progenitor Cells.- Meis1 Regulates Post-Natal Cardiomyocyte
Cell Cycle Arrest.- Intercellular signalling in cardiac development and
disease: NOTCH.- The epicardium in ventricular septation during evolution
and development.- S1P-S1p2 signaling in cardiac precursor cells migration.- Myogenic progenitor cell differentiation is dependent on modulation of
mitochondrial biogenesis through autophagy.- The role of the
thyroid in the developing heart.-
Part IV. Valve Development and Diseases.- Atrioventricular valve abnormalities: From molecular mechanisms
underlying morphogenesis to clinical perspective.- Molecular
Mechanisms of Heart Valve Development and Disease.- A novel role for
endocardium in perinatal valve development: Lessons learned from tissue
specific gene deletion of the Tie1 receptor tyrosine kinase.- The Role of the Epicardium in the Formation of the Cardiac Valves in
the Mouse.- TMEM100, a novel intracellular transmembrane protein
essential for vascular development and cardiac morphogenesis.- Cell autonomous regulation of BMP-2 in endocardial cushion cells during
AV valvuloseptal morphogenesis.-
Part V. The Second Heart Field and Outflow Tract.- Properties of cardiac progenitor cells in the second heart field.- Nodal signaling and congenital heart defects.- Utilizing
Zebrafish to Understand Second Heart Field Development.- A history and
interaction of outflow progenitor cells implicated in “Takao syndrome”.- The loss of Foxc2 expression in the outflow tract links the interrupted
arch in the conditional Foxc2 knockout mouse.- Environmental
modification for phenotype of truncus arteriosus in Tbx1 hypomorphic mice.- Part VI. Vascular Development and
Diseases.- Extracellular matrix remodeling in
vascular development and disease.- The “cardiac neural crest” concept
revisited.- Roles of endothelial Hrt genes for vascular development.- Placental Expression of Type 1 and 3 Inositol Trisphosphate Receptors
is Required for the Extra-embryonic Vascular Development.- Tissue Remodeling in Vascular Wall in Kawasaki Disease-related
Vasculitis Model Mice.- Part
VII. Ductus Arteriosus.- Progerin
expression during normal closure of the human ductus arteriosus: A case of
premature ageing?.- The multiple roles of prostaglandin E2 in the regulation of
the ductus arteriosus.- Developmental Differences in the Maturation of Sarcoplasmic
Reticulum and Contractile Proteins in Large Blood Vessels Influences Their
Contractility.- Fetal and Neonatal Ductus Arteriosus is Regulated with
ATP-sensitive Potassium Channel.-
Part VIII. Conduction System and Arrhythmia.- Regulation of vertebrate conduction system development.- Cardiac Pacemaker Development from a Tertiary Heart Field.- Endothelin receptor type A expressing cell population in the inflow
tract contributes to chamber formation.- Specific isolation of HCN4 positive
cardiac pace-making cells derived from embryonic stem cell.- Part IX. Current Molecular Mechanism
in Cardiovascular Development.- Combinatorial
functions of transcription factors and epigenetic factors in heart development
and disease.- Pcgf5 contributes to PRC1 (Polycomb repressive complex 1)
in developing cardiac cells.-
non-coding RNAs in cardiovascular disease.- Part X. iPS Cells and Regeneration in
Congenital Heart Diseases.- Human
pluripotent stem cells to model congenital heart disease.- Engineered cardiac tissues generated from immature cardiac and
stem-cell derived cells: Multiple approaches and outcomes.- Dissecting the left heart hypoplasia by pluripotent stem cells.- Lentiviral gene transfer to iPS cells; toward the cardiomyocyte
differentiation of Pompe disease-specific iPS cells.- Molecular
analysis of long-term cultured cardiac stem cells for cardiac regeneration.- Epicardial contribution in neonatal heart regeneration.- Part XI. Current Genetics in
Congenital Heart Diseases.- Genetic
discovery for congenital heart defects.- Evidence that deletion of ETS-1, a
gene in the Jacobsen syndrome (11q-) cardiac critical region, causes congenital
heart defects through impaired cardiac neural crest cell function.- Notch signaling in aortic valve development and disease.- To detect and explore mechanism of CITED2 mutation and methylation in
children with congenital heart disease.