Patient-Derived Mouse Models of Cancer (eBook)

R.M. Hoffman has been a cancer researcher since 1965.  Dr. Hoffman is the pioneer of the patient-derived orthotopic xenograft (PDOX) mouse model, which is featured in the present volume.  Dr. Hoffman is a pioneer in many areas of cancer research described in his almost 1,000 scientific publications that have been cited more than 35,000 times with an h-index of almost 100.  Dr. Hoffman is currently a Professor of Surgery at the University of California San Diego and Founding President of AntiCancer Inc.

1. In memorium:  Jorgen Rygaard (1934-2016) Father of patient derived mouse models of cancer and modern cancer research. 2. The revival of patient-derived mouse models of cancer:  way back to the future3. Patient-derived xenograft models for human cancer, The Freiburg experience 4. From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype5. The Effects of the Organ Microenvironment on Metastatic-Cell Gene Signatures 6. Techniques for surgical orthotopic implantation of human tumors to immunodeficient mice7. The first patient-derived orthotopic xenograft (PDOX) mouse models of cancer: Cancer of the colon, pancreas, lung, breast, ovary, and mesothelioma 8. Patient-derived xenograft models of prostate cancer9. Patient-Derived Mouse Models of Sarcoma 10. Cervical cancer patient-derived orthotopic xenograft (PDOX) models11. The use of pediatric patient-derived xenografts for identifying novel agents and combinations12. Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics13. Use of patient-derived orthotopic xenografts (PDOX) to evaluate transformative cancer therapeutics14. Fluorescent protein-expressing transgenic nude mice as hosts for patient tumors15. Fluorescence imaging of tumors in human patient-derived orthotopic xenograft (PDOX) mouse models:  The iPDOX model16. The use of patient-derived orthotopic xenograft (PDOX) models to develop curative fluorescence-guided surgery of cancer 17. Molecular characteristics of patient-derived tumor xenografts: genomic similarity to patient tumors and relevance for biomarker discovery18. Complementarity of patient-derived orthotopic xenografts (PDOX) models and molecular profiling for optimal therapy19. 3D Cell Culture Models20. Why patient derived mouse models need to be orthotopic21. Foreward: The future of patient-derived models of cancer