Total Intravenous Anesthesia and Target Controlled Infusions (eBook)

Anthony  R. Absalom, MBChB, FRCA, MDProfessor of Anesthesiology, The University Medical Center Groningen, University of Groningen, The NetherlandsDr. Absalom is internationally recognized as a leading expert on anaesthetic pharmacology and total intravenous anesthesia. He currently serves as Editor of the British Journal of Anaesthesia and is a former editorial board member of Trends in Anaesthesia and Critical Care.  He is currently president of the Society for Intravenous Anesthesia (UK). In the past he has served as a board member of ISAP (International Society for Intravenous Anaesthesia) and as vice-president of the World Society of Intravenous Anaesthesia. Keira P. Mason, MD is an Associate Professor of Anaesthesia (Radiology) at Harvard Medical School, , Boston Children’s Hospital, Boston, MA. Dr. Mason is a Springer author.  We recently published the expanded Second Edition of her critically and globally acclaimed book, Pediatric Sedation Outside of the Operating Room, 2nd ed, Mason, ed., (2015).  During 1998-2014, Dr. Mason was Director of Radiology Anesthesia and Sedation at Boston Children’s Hospital, where she developed a sedation and anesthesia program that continues to be nationally and internationally recognized.  She is considered a pioneer of innovative and safe sedation protocols which have been adopted worldwide.  Dr. Mason is past- Vice President of the World Society of Intravenous Anesthesia (Founding Board Member), and a frequent invited lecturer to national and international conferences, including Society of Interventional Radiology, American Society of Anesthesiologists, Radiological Society of North America, International Dental Congress on Anesthesia, Sedation, and Pain Control, Society of Ambulatory Anesthesia, Asian and Oceanic Society of Regional Anesthesia, Japanese Society for Intravenous Anesthesia, International Association of Pediatric Dentistry, All-African Anaesthesia Congress, Asian Society of Paediatric Anesthesiologists, and many others. She is the Course Director for Pediatric Sedation Outside the Operating Room, a conference she initiated through Harvard Medical School and is an active member of the American Society of Anesthesiologists (ASA) Committees. She has authored many book chapters.  As a Principal Investigator of numerous studies, some which required approval of the Food and Drug Administration (FDA), she has numerous publications. Dr. Mason continues to serve on expert panels for the FDA.  She is on the Editorial Board of the British Journal of Anaesthesia.

CONTENTS

 

 

PART 1.  INTRODUCTION/BACKGROUND

 

1. When and How Did It All Begin? A Brief History of Intravenous Anesthesia

John Sear

 

2. The Development and Regulation of Commercial Devices for Target - Controlled Drug Infusion

John B Glen

 

3. The Memory Labyrinth: systems, processes and boundaries             

Robert A. Veselis

 

4. Consciousness and Anaesthesia  

Ram Adapa

 

5. Mechanisms of Intravenous Anaesthetic Action

Hugh C. Hemmings Jr and Karl F. Herold

 

 

PART 2.  PRINCIPLES OF PHARMACOLOGICAL MODELING

 

6. Basic Pharmacology: Kinetics and Dynamics for Dummies    

Johan Raeder

 

7. Pharmacokinetic-Pharmacodynamic Modelling of Anesthetic Drugs

Johannes Hans Proost

 

8. Principles of Target Controlled Infusions

Steven L. Shafer

 

9.  Performance of Target-Controlled Infusion Systems

Matthew TV Chan

 

10. How to Select a PK/PD Model

Kenichi Masui

 

 

PART 3.  PHARMACOLOGY OF THE INTRAVENOUS ANESTHETIC AGENTS

 

11. Propofol PK-PD

Douglas J. Eleveld

12. Etomidate and Etomidate Analogues: Molecular Pharmacology and Behavioral Actions

Douglas E. Raines

 

13. Dexmedetomidine: The Science and Clinical Aspects in Adults and Children

Mohamed Mahmoud

 

14. Clinical Effects and Applications of Ketamine

Mark G. Roback

 

15. Neuromuscular Blocking Drugs: Pharmacology, Physiology and Clinical Aspects

Claude Meistelman

16. New and Upcoming Drugs: Intravenous Anesthetic Agents John William Sear

 

17. Drug Interactions in Anesthesia

 Jaap Vuyk

 

 

 

PART 4. PRACTICAL CONDUCT OF SEDATION AND ANESTHESIA

18. Pumps Pitfalls and Practicalities

Frank Engbers

 

19. EEG Monitoring of Depth of Anesthesia

Michael Sury

 

20. Monitoring the analgesic component of anesthesia

Isabelle Constant

 

21. Intravenous Drugs for Sedation: Target Controlled, Patient Controlled, and Patient Maintained Delivery

Keith J Anderson and Gavin NC Kenny

 

22. Pediatric TIVA/TCI: Case Presentations and Discussion      

Vivian Man-ying  Yuen

 

23. TCI/TIVA Adult Case Studies

Nicholas Sutcliffe

  

PART 5. SPECIAL POPULATIONS AND PROCEDURES

 

24. Intravenous Anesthesia in Obese Patients

Pablo Sepúlveda and Ignacio Cortínez

 

25. Pharmacokinetics and Dynamics on the Pediatric Population

Brian J. Anderson

 

26. Clinical Pharmacology of Intravenous Sedation in Children

Oliver Bagshaw

 

27. Sedation of the Critically Ill Child

Arno Brouwers, Sanne Vaassen, Gijs D Vos, Jan NM Schieveld, and Piet L Leroy

 

28. TCI & TIVA for Neurosurgery: Considerations and Techniques Massimo Lamperti and Fazil Ashiq

 

29. TCI in Special Patients Groups: The Elderly and Obese

Frederique S Servin

 

30. TIVA for Cardiac Surgery

Stefan Schraag

 

31. TIVA/TCI in Veterinary Practice

Thierry Beths

 

 

PART 6. OUTCOME, EDUCATION, SAFETY, AND THE FUTURE

 

32. Advantages, Disadvantages, and Risks of TIVA/TCI

Ken B Johnson

 

33. Economics of TIVA

Jane Montgomery and Mary Stocker

 

34. Teaching TCI with Human Patient Simulators

Wolfgang Heinrichs

 

35. Closed-Loop or Automated Titration of Intravenous Anesthesia: Background, Science and Clinical Impact

Ngai Liu

 

36. Health Care Technology, the Human-Machine Interface, and Patient Safety During Intravenous Anesthesia

Craig S. Webster

 

37.  Can IV Sedatives Affect Outcome?

Christopher G. Hughes, Christina J. Hayhurst, and Pratik P. Pandharipande

 

38. The Benefit and Future of Pharmacogenetics

Janko Samardzic, Dubravka Svob Strac,  and John N. van den Anker

 

39. Lessons from drug interaction displays

Ross Kennedy

 

40. The Role of Intravenous Agents in Delirium

Claudia Spies, Susanne Koch, Alissa Wolf, Rudolf Mörgeli, and Björn Weiss

 

41. Perioperative Cardioprotective Strategies in Noncardiac Surgery

Stefan De Hert

 

42. Opioid Induced Hyperalgesia after Surgery: Clinical Relevance

Dr. Philippe Richebe

 

43. Memory, Awareness and Intravenous Anaesthetics               

Michael Wang

 

44. Awareness and Dreaming During TIVA

Kate Leslie

 

45. Apoptosis and Neurocognitive Effects of Intravenous Anesthetics   

Sulipicio Soriano and Laszlo Vutskits

 

 

Epilogues