Neuroimmune Pharmacology (eBook)

Howard E. Gendelman is the Margaret R. Larson Professor of Medicine and Chair of the Department of Pharmacology and Experimental Neuroscience and Director of the Center for Neurodegenerative Disorders at the University of Nebraska Medical Center.Tsuneya Ikezu is Professor in the Department of Pharmacology and Experimental Therapeutics at Boston University School of Medicine with joint appointments in the Department of Neurology and Boston University Alzheimer’s Disease Center. He also leads the Laboratory of Molecular NeuroTherapeutics.

Preface.- Introduction.- Innate and adaptive Immunity in Health and Disease.- The Blood-Brain Barriers.- Regulation of Nervous System Function by Circumventricular Organs.- Anterior Chamber and Retina (Structure, Function and Immunology).- Hippocampus, Spatial Memory and Neuroimmunomodulation.- Anatomical Networks: Structure and Function of the Nervous System.- Inflammasomes in the Central Nervous System: Immune Sensors and Effectors of Health and Disease.- LRRK2: A Kinase at the Crossroads of Neuroimmune Interactions in the Pathogenesis of Chronic Inflammatory Disease and Parkinson’s Disease.- Astrocytes, Oligodendrocytes and Schwann Cells.- Macrophages, Microglia And Dendritic Cells: Biology And Function.- Mononuclear Phagocytes.- Cellular Composition, Biology and Physiology: Microglia.- The Vertebrate Retina.- Human Lymphocyte Biology and Its Application To Humanized Mice.- Stem Cells and Neurogenesis for Brain Development, Degeneration and Therapy.- Innate Immunity Signaling.- Cytokines and Chemokines.- Growth and Neurotrophic Factors for HIV-Associated Neurocognitive Disorders.- RNA Binding Proteins in Health and Disease.- Exosomes and Neuroregulation.- MicroRNA Implications in Neurodegenerative Disorders.- Neurodegeneration.- Multiple Sclerosis: Pathogenesis and Disease Application.- Guillain-Barre, Chronic Inflammatory Demyelinating Polyradiculoneurophathy, and Axonal Degeneration and Regeneration.- Guillian-Barré Syndrome and Acute Neuropathy.- Autoimmunity in Neurologic Disease.-  HIV-Associated Neurocognitive Disorders.- Neuroimmunomodulation of Human T-Lymphotrophic Virus Type I/II Infection.- Viral Encephalitis.- Alzheimer’s Disease.- Parkinson’s Disease.- Neuroinflammation: A Key to Clinical Heterogeneity in Amyotrophic Lateral Sclerosis.- Neuroimmune Response and Inflammation in Huntington’s Disease.- Human Prion Diseases.- Glaucoma.- Ocular Manifestations of Systemic Autoimmune Diseases.- Neurogenesis and Brain Repair.- Chronic Traumatic Encephalopathy.- Molecular, Cellular and Physiological Mechanisms of Psychiatric Disorders. The Neuroimmune System in Psychiatric Disorders (Overview).- Autism Spectrum Disorders.- Drugs of Abuse and the Immune System.- Therapeutic Strategies in Neurodegenerative Diseases.- Immunomodulatory Therapy for Multiple Sclerosis.- Therapeutic Considerations in HIV-Associated Neurocognitive Disorders.- Immunotherapy for Alzheimer’s Disease.- Immunotherapies for Movement Disorders: Parkinson’s Disease and Amyotrophic Lateral Sclerosis.- Regenerative and Repair Strategies for the Central Nervous System.- New Generation of Adjuvants for Protection against Disease and to Combat Bioterrorism.- Medicinal Chemistry and Brain Drug Penetrance.- Polymer Nanomaterials for Drug Delivery Across the Blood Brain Barrier.- Macromolecular Therapeutics – Development and Delivery Engineering.- Application to Gene Therapy and Vaccination.- Introduction to Imaging in the Neurosciences.- Proteomics and Genomics in Neuroimmunological Disorders.- Pharmacogenomics of Neurodegenerative Diseases: Roles in Personalized Medicines.- Conclusion.- Glossary.- Index.