Psoriasis

M. Alan Menter Department of Dermatology, Baylor University Medical Centre, Dallas, Texas Caitriona Ryan Department of Dermatology, St Vincent's University Hospital, Dublin, Ireland  

The history of psoriasis. Epidemiology. Microscopic findings. Genetics. Immunology. Other environmental risk factors. Plaque type psoriasis: Chronic plaque, guttate, and erythrodermic phenotypes. Palmoplantar psoriasis. Generalised pustular psoriasis. Inverse psoriasis and genital disease. Nail psoriasis. Differential diagnoses of psoriasis. Genetics, immunology, and pathogenesis. Psoriatic arthritis: Clinical manifestations. Pediatric psoriasis. Cardiometabolic comorbidities. Psychiatric comorbidities. Other disease associations: Liver, gastrointestinal, respiratory, and neoplastic. Assessment and measurement of disease. Current and future topical treatments for psoriasis. Phototherapy and photochemotherapy.Traditional systemic therapies and monitoring guidelines. Current biologic therapies (including IL-17) and monitoring guidelines. Current and future oral small molecules. Biologic therapies in the pipeline. Future directions and personalized medicine. Conclusion.