Stem Cells in Toxicology and Medicine (eBook)

Dr. Saura C. Sahu Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of "Hepatotoxicity" (Wiley, 2007), "Toxicogenomics" (Wiley, 2008), "Nanotoxicity" (Wiley, 2009), and "Handbook of Systems Toxicology" (Wiley, 2011).

List of contributors

Preface

Acknowledgements

PART I

1. Introduction
Sara C. Sahu

2. Application of Stem cells and iPS cells in Toxicology
Maria Virginia Caballero, Ramon Espinoza Lewis and Manila Candiracci

3. Stem cells: A potential source for high throughput screening in toxicology
Harish K Handral, Gopu Sriram and Tong Cao

4. Human pluripotent stem cells for toxicological screening
Du Lili and Chen Dunjin

5. Effects of culture conditions on maturation of stem cell-derived cardiomyocytes
Deborah K. Hansen, Amy L. Inselman and Xi Yang

6. Human stem cell-derived cardiomyocyte in vitro models for cardiotoxicity screening
Tracy Walker, Kate Harris, Evie Maifoshie, Khuram Chaudhary

7. Disease-Specific Stem Cell Models for Toxicological Screenings and Drug Development
Matthias Jung, Juliane-Susanne Jung, Jovita Schiller and Insa S. Schroeder

8. Three-dimensional culture systems and humanized liver models using hepatic stem cells for enhanced toxicity assessment
Ran-Ran Zhang, Yun-Wen Zheng, Hideki Taniguch)

9. Utilization of in vitro neurotoxicity models in pre-clinical toxicity assessment
Karin Staflin, Dinah Misner, and Donna Dambach

10. A human stem cell model for creating placental syncytiotrophoblast, the major cellular barrier that limits fetal exposure to xenobiotics
R. Michael Roberts, Shinichiro Yabe, Ying Yang, and Toshihiko Ezashi

11. Effects of Endocrine Disruptors on Mesenchymal Stem Cells
Marjorie Bateman, Amy Strong, John McLachlan, Matthew Burow, Bruce Bunnell

12. Epigenetic Landscape in Embryonic Stem Cells
Xiaonan Sun, Nicholas Spellmon, Joshua Holcomb, Wen Xue, Chunying Li and Zhe Yang

PART II

13. The Effect of Human Pluripotent Stem Cell Platforms on Preclinical Drug Development
Kevin G. Chen

14. Generation and application of 3D culture systems in human drug discovery and medicine
Rashidi H and Hay DC

15. Characterization and therapeutic uses of adult mesenchymal stem cells
Julian Kiang

16. Stem Cell Therapeutics for Cardiovascular Diseases
Yuning Hou, Xiaoqing Guan, Shukkur M. Farooq, Xiaonan Sun, Peijun Wang, Zhe Yang, and Chunying Li

17. Stem cell-based therapies for vascular regeneration in peripheral artery diseases
David Smadia and Jean-Sebastien Silvestre

18. Gene modified stem/progenitor cell therapy for ischemic stroke
Yaning Li, Guo-Yuan Yang, and Yongting Wang

19. Role of stem cells in the gastrointestinal tract and in the development of cancer
Pengyu Huang, Bin Li, Yun-Wen Zheng)

20. Cancer stem cells: Concept, significance and management
Haseeb Zubair, Shafquat Azim, Sanjeev Srivastava, Arun Bhardwaj, Saravanakumar Marimuthu, Mary Patton, Seema Singh, Ajay Singh

21. Stem cell signaling in the heterogenous development of medulloblastoma
Joanna Triscott and Sandra Dunn

22. Induced pluripotent stem cell-derived ocular blood-retinal barrier for disease modeling and drug discovery
Jun Jeon, Nathan Hotaling, Kapil Bharti

23. Important considerations in the therapeutic application of stem cells in bone healing and regeneration
Hoda Elkhenany, Shawn Bourdo, Alexandru Biris, David Anderson and Madhu Dhar

24. Stem cells from human dental tissue for regenerative medicine
Junjun Liu and Shangfeng Liu

25. Stem cells in the skin
Hongwei Wang, Zhonglan Su, Shiyu Song, Ting Su , Mengyuan Niu, Yaqi Sun, Hui Xu

Index