Genotoxicity Assessment

Bacterial Mutation Assays.- In Vitro Mouse Lymphoma (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay.- Erythrocyte--Based Pig--a Gene Mutation Assay.- Detection of in vivo Mutation in the Hprt and Pig--a Genes of Rat Lymphocytes.- In vivo cII, gpt, and Spi- gene Mutation Assays in Transgenic Mice and Rats.- In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests.- Analysis of Chromosome Aberrations in Somatic and Germ Cells of the Mouse.- Chromosomal Aberration Test in Human Lymphocytes.- In vivo Micronucleus Assay in Mouse Bone Marrow and Peripheral Blood.- Micronucleus Assay in Human Cells: Lymphocytes and Buccal Cells.- Flow Cytometric Determination of Micronucleus Frequency.- Fluorescent in situ Hybridization (FISH) Technique for the Micronucleus Test.- Comparative Genomic Hybridization (CGH) in Genotoxicology.- The in vitro Micronucleus Assay and Kinetochore Staining: Methodology and Criteria for the Accurate Assessment of Genotoxicity and Cytotoxicity.- g--H2AX Detection in Somatic and Germ Cells of Mice.- Multicolour Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers.- The Comet Assay: Assessment of in vitro and in vivo DNA Damage.- The Comet Assay in Human Biomonitoring.- The Comet assay in Marine Animals.- Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo.- 32P--Postlabeling Analysis of DNA Adducts.- Micronucleus Assay with Tetrad Cells of Tradescantia.- The Wing--Spot and the Comet Tests as useful Assays Detecting Genotoxicity in Drosophila.- Genotoxicity Guidelines Recommended by International Conference of Harmonization (ICH).