Small Molecules in Oncology -

Small Molecules in Oncology

Uwe M. Martens (Herausgeber)

Buch | Softcover
XVI, 417 Seiten
2016 | 2. Softcover reprint of the original 2nd ed. 2014
Springer Berlin (Verlag)
978-3-662-51925-7 (ISBN)
128,39 inkl. MwSt
Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Imatinib Mesylate.- Erlotinib.- Axitinib (AG-013736).- Lapatinib.- Sorafenib.- Sunitinib.- Dasatinib.- Nilotinib.- Bosutinib.- Decitabine.- Azacytidine/Azacitidine.- Bortezomib.- Temsirolimus.- Danusertib.- Vismodegib.- Everolimus.- Vemurafenib.- Vandetanib.- Trametinib.- Dabrafenib.- Ponatinib.- Regorafenib.- Cabozantinib.- Revlimid.- Ibrutinib.- Qizartinib.- Ruxolitinib.- Carfilzomib.- Afitinib.

"The book is recommended for healthcare professionals, scientists, and students in medical and scientific fields. In 25 well-written chapters, experts in their fields of research describe in great detail 12 compounds currently in clinical use for the treatment of hematological malignancies, and 13 compounds applicable to specific mutation-containing malignancies or aimed at interfering with the microenvironment (such as angiogenesis). ... This book provides important practical information on a wide variety of novel small molecule-based treatment approaches." (George Somlo, Doody's Book Reviews, April, 2015)

Erscheinungsdatum
Reihe/Serie Recent Results in Cancer Research
Zusatzinfo XVI, 417 p. 46 illus., 26 illus. in color.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizinische Fachgebiete Innere Medizin Hämatologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Schlagworte Cancer Research • Haematology • Hematology • Medicine • Molecular mechanisms of cancer • Oncogenic protein kinase inhibitors • Oncology • targeted therapy • Treatment of malignant diseases
ISBN-10 3-662-51925-9 / 3662519259
ISBN-13 978-3-662-51925-7 / 9783662519257
Zustand Neuware
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