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Small Molecules in Oncology

Uwe M. Martens (Herausgeber)

Buch | Hardcover

XVI, 417 Seiten

2014 | 2nd ed. 2014
Springer Berlin (Verlag)
978-3-642-54489-7 (ISBN)

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Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Imatinib Mesylate.- Erlotinib.- Axitinib (AG-013736).- Lapatinib.- Sorafenib.- Sunitinib.- Dasatinib.- Nilotinib.- Bosutinib.- Decitabine.- Azacytidine/Azacitidine.- Bortezomib.- Temsirolimus.- Danusertib.- Vismodegib.- Everolimus.- Vemurafenib.- Vandetanib.- Trametinib.- Dabrafenib.- Ponatinib.- Regorafenib.- Cabozantinib.- Revlimid.- Ibrutinib.- Qizartinib.- Ruxolitinib.- Carfilzomib.- Afitinib.

lt;p>"The book is recommended for healthcare professionals, scientists, and students in medical and scientific fields. In 25 well-written chapters, experts in their fields of research describe in great detail 12 compounds currently in clinical use for the treatment of hematological malignancies, and 13 compounds applicable to specific mutation-containing malignancies or aimed at interfering with the microenvironment (such as angiogenesis). ... This book provides important practical information on a wide variety of novel small molecule-based treatment approaches." (George Somlo, Doody's Book Reviews, April, 2015)

Erscheint lt. Verlag	12.5.2014
Reihe/Serie	Recent Results in Cancer Research
Zusatzinfo	XVI, 417 p. 46 illus., 26 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	812 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Schlagworte	Molecular mechanisms of cancer • Oncogenic protein kinase inhibitors • targeted therapy • Treatment of malignant diseases
ISBN-10	3-642-54489-4 / 3642544894
ISBN-13	978-3-642-54489-7 / 9783642544897
Zustand	Neuware