Biomarkers in Cancer Screening and Early Detection

Sudhir Srivastava, Ph.D., MPH Senior Scientific Officer, Chief, Cancer Biomarkers Research Group
Division of Cancer Prevention, National Cancer Institute
Bethesda, MD, USA
Dr Srivastava has received many honors and awards and is a member of several scientific committees (AJCC, AACR, All Ireland-NCI Consortium). Dr. Srivastava is a founding member of HUPO (Human Proteome Organisation) and has actively participated in the Plasma Proteome and the Liver Proteome Projects. He is the principal architect of the NCI's Early Detection Research Network and Alliance of Glycobiologists for the Detection of Cancer and Cancer Risk. He supported the first-ever joint meetings of EDRN-HUPO PPP and Proteomics Jamboree, and recently-held the US-Japan meeting on Glycolic. He has published more than 200 research papers, review articles and commentaries in peer reviewed journals. HJ has edited two other books: Informatics in Proteomics and Nanotechnology for Cancer Detection and Diagnosis (forthcoming). He is also the Editor-in Chief of the journals Disease Markers and Cancer Biomarkers.

List of Contributors, ix
Preface, xiii
Part I Foundations of Biomarker Research
1 Nuts and Bolts of Biomarker Research, 3
Sharmistha Ghosh and Sudhir Srivastava
2 Cancer Genome Methylation: Biology, Biomarker and Therapeutic Opportunities, 16
Shashwat Sharad, Taduru Sreenath, Shiv Srivastava, and Albert Dobi
3 MicroRNA Biomarkers for Early Detection of Cancer, 27
WendyWang, Matthew R Young, and Sudhir Srivastava
4 Inflammation and Cancer, 37
Pamela L Beatty, Sandra Cascio, and Olivera J Finn
5 Exosomes: A Valuable Biomedical Tool in Biomarker Discovery and Development, 50
Jocelyn Lee, Sharmistha Ghosh, and Sudhir Srivastava
6 Epithelial-to-Mesenchymal Transition (EMT): Clinical Implications, 64
Elisa CWoodhouse and Suresh Mohla
Part II State-of-the-Science in Organ-Specific Biomarker Research
7 Breast Cancer, 77
Benjamin A Katchman, Christos Patriotis, and Karen S Anderson
8 Ovarian Cancer, 93
Christos Patriotis, Archana Simmons, Karen H Lu, Robert C Bast, Jr, and Steven J Skates
9 Esophageal Cancer Biomarkers, 104
Yanxin Luo, Kishore Guda, SanfordD Markowitz, Amitabh Chak, Andrew M Kaz, andWilliam M Grady
10 Predictive Biomarkers for Therapy in Adenocarcinoma of the Upper Digestive Tract, 118
Heath D Skinner, Qiongrong Chen, Elena Elimova, RoopmaWadhwa, Shumei Song, and Jaffer A Ajani
11 Pancreatic Cancer, 130
Sam CWang and Peter J Allen
12 Colon Cancer, 141
Paul DWagner
13 Prognostic and Predictive Biomarkers for Colorectal Cancer, 151
Upender Manne, Balananda-Dhurjati Kumar Putcha, Temesgen Samuel, and Sudhir Srivastava
14 Early Detection of Lung Cancer, 163
Mohamed Hassanein, Melinda C
Aldrich, Stephen A Deppen, Karl E
Krueger, Eric L Grogan, and Pierre P Massion
15 Commonalities in Lung Cancer and
COPD, 185
MalgorzataWojtowicz and Eva Szabo
16 Prostate Cancer, 197
Jacob Kagan, Ian M Thompson, and
DanielWChan
Part III Biomarkers, Screening and Precision Health: Implications for Public Health
17 Improving the Clinical Validity of
Biomarker Research in Cancer
Detection, 209
David F Ransohoff
18 Cancer Overdiagnosis, Ramifications
and Research Strategies, 220
Barbara K Dunn and Barnett S Kramer
19 Predictive Markers and Driver Genes
From Treatment Trials: Potential
Utility For Early Diagnosis, 231
Brian S Sorg, Sarfraz Memon, Kelly Y
Kim, Aniruddha Ganguly, Tracy Lively,
James Tricoli, Magdalena Thurin,
Lokesh Agrawal, Tawnya C McKee,
Barbara A Conley, and J Milburn Jessup
20 Statistical Consideration in Predictive
and Prognostic Markers, 245
Fei Ye and Yu Shyr
21 Clinical Validation of Molecular
Biomarkers in Translational Medicine, 256
Harry B Burke andWilliam E Grizzle
22 Cancer Biomarker Assays:
Performance Standards, 267
Anna K F¨uz´ery and DanielWChan
23 Bioethics and Cancer
Biomarker Research, 277
Nathan Nobis, William Grizzle, and
Stephen Sodeke
24 Colon Cancer Screening, 283
Molly Perencevich, Jennifer Inra, and
Sapna Syngal