High-Risk Cutaneous Squamous Cell Carcinoma (eBook)

Chrysalyne Schmults, MD, MSCEDirector, Mohs & Dermatologic Surgery CenterBrigham & Women’s HospitalDepartment of Dermatology1153 Centre St., Suite 4349Jamaica Plain, MA 02130, USA

Table of Contents

 

High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management

 

 

 

Chrysalyne D. Schmults, editor

 

 

Dedication

Preface

 

 

 

Part I. Defining the Problem of High-risk SCC

 

Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma Pritesh S. Karia

 

Tumor Staging Systems and Prognostic Stratification Anokhi Jambusaria-Pahlajani

 

Part II. The Science of SCC

 

Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-risk Cutaneous Squamous Cell Carcinoma Catherine Anne Harwood, Charlotte Proby, Sarah Arron

 

Molecular and Cellular Interplay in SCC Including Immunomodulation and Clinical Implications Valerie Yanofsky, John A. Carucci, Günther F.L. Hofbauer

 

Part III. Management of High-risk SCC

 

Management of Patients with Multiple SCCs/Field Cancerization Sasha Jenkins Haberle, Lauren Rimoin, Myrto Georgia Trakatelli, Fiona Zwald

 

Management of High-Risk Primary Tumors including Nodal Staging Vishal Anil Patel, Christian L. Baum, Désirée Ratner

 

Management of Local Recurrence and In-transit Metastasis Vitaly Terushkin, John A. Carucci

 

Management of Nodal Metastases Michael Veness, Julie Howle

 

Management of Widely Metastatic and Unresectable Cutaneous Squamous Cell Carcinoma Glenn J. Hanna, Emily Stamell Ruiz, Jochen H. Lorch

 

Immune Dysfunction and Immunosuppression: Impacts on SCC Incidence, Prognosis, and Management Travis W. Blalock, Thomas Stasko