Circulating Tumor Cells (eBook)

Z. Hugh Fan, PhD, is a professor of the Department of Mechanical and Aerospace Engineering, J. Crayton Pruitt Family Department of Biomedical Engineering, and Department of Chemistry at the University of Florida (UF), USA. Prior to joining UF in 2003, Dr. Fan was a Principal Scientist at ACLARA BioSciences Inc. and was previously a Member of the Technical Staff at Sarnoff Corp. Dr. Fan has been recognized with E.T.S. Walton Award from Science Foundation of Ireland in 2009, Fraunhofer-Bessel Research Award from Alexander von Humboldt Foundation (Germany) in 2010, and UF Research Foundation Professorship in 2014.

Preface

Part I Introduction

1 Circulating tumor cells and historic perspectives
Jonathan W. Uhr

2 Introduction to microfluidics
Kangfu Chen, Z. Hugh Fan

Part II Isolation Methods

3 Ensemble-decision Aliquot Ranking (eDAR) for CTC Isolation and Analysis
Mengxia Zhao, Perry G. Schiro, Daniel T. Chiu

4 Sinusoidal Microchannels with High Aspect Ratios for CTC Selection and Analysis
Joshua M. Jackson, Steven A. Soper, Malgorzata A. Witek

5 Cell Separation Using Inertial Microfluidics
Nivedita Nivedita, Ian Papautsky

6 Morphological Characteristics of CTCs and the Potential for Deformability-based Separation
Simon P. Duffy, Hongshen Ma

7 Microfabricated filter membranes for capture and characterization of Circulating Tumor Cells
Zheng Ao, Anthony Williams, Richard J. Cote, Ram H. Datar

8 Miniaturized Nuclear Magnetic Resonance Platform for Rare Cell Detection and Profiling
Sangmoo Jeong, Changwook Min, Huilin Shao, Arezou Ghazani, Cesar M. Castro, Ralph Weissleder, Hakho Lee

9 NanoVelcro Cell-Affinity Assay for Detection and Characterization of Circulating Tumor Cells
An-Jou Liang, Anna Fong, Hsian-Rong Tseng, Jie-fu Chen, Millicent Lin, Min Song, Morgan Fong, Qingyu Li, Shang-Fu Chen, Sharon Chen, Shuang Hou, Yang Zhang, Zunfu Ke

10 Acoustophoresis for tumor cell enrichment
Thomas Laurell, Per Augustsson, Cecilia Magnusson, Hans Lilja

11 Photoacoustic flow cytometry for detection and capture of circulating melanoma cells
John A. Viator, Benjamin S. Goldschmidt, Kiran Bhattacharyya, Kyle Rood

12 Selectin-Mediated Targeting of Circulating Tumor Cells for Isolation and Treatment
Jocelyn Marshall, Michael King

13 Aptamers-enabled tumor cell isolation
Jinling Zhang, Z. Hugh Fan

14 Depletion of normal cells for CTC enrichment
Jeffrey J. Chalmers, Maryam B. Lustberg, Clayton Deighan, Kyoung-Joo Jenny Park, Yongqi Wu, Peter Amaya

Part III Post-Isolation Analysis and clinical translation

15 Tumor heterogeneity and single cell analysis of CTCs
Evelyn Kidess Sigal, Stefanie S. Jeffrey

16 Single-cell molecular profiles and biophysical assessment of circulating tumor cells
Chun-Liang Chen, Maria E. Gaczynska, Aaron M. Horning, Chun-Lin Lin, Anna D. Louis, Devalingam Mahalingam, Pawel Osmulski, Chiou-Miin Wang

17 Directing Circulating Tumor Cell Technologies into Clinical Practice
Benjamin P Casavant, David T Kosoff, Joshua M Lang

Part IV Commercialization

18 DEPArray(TM) Technology for Single CTC-analysis
Farideh Z. Bischoff, Nicolò Manaresi, Gianni Medoro

19 CELLSEARCH® instrument, features, and usage
Denis A. Smirnov, Brad W. Foulk, Mark C. Connelly, Robert T. McCormack

Glossary
Jose Varillas, Z. Hugh Fan

Index