Holland-Frei Cancer Medicine

Robert C. Bast Jr, MD, Vice President for Translational Research, MD Anderson Cancer Center, Houston, TX, USA

Carlo M. Croce, MD, Distinguished University Professor, The John W. Wolfe Chair in Human Cancer Genetics, Professor and Chair, Department of Molecular Virology, Immunology and Medical Genetics, The Wexner Medical Center, The Ohio State University, Columbus, OH, USA

William Hait, MD, PhD, Global Head research and Development, Janssen pharmaceutical companies of Johnson and Johnson, NJ, USA

Waun Ki Hong, MD, DMSc, Professor of Thoracic/Head and Neck Medical Oncology, American Cancer Society Professor, Samsung Distinguished University Chair in Cancer Medicine Emeritus, The University of Texas M.D.Anderson Cancer Center, Houston, TX, USA

Donald W. Kufe, MD, Distinguished Physician, Dana-Farber Cancer Institute, Professor of Medicine Harvard Medical School, Leader, Translational Pharmacology and Early Therapeutic Trials Program Dana-Farber/Harvard Cancer Center, Boston, MA, USA

Martine Piccart-Gebhart MD PhD, Professor of Oncology, Université Libre de Bruxelles (ULB), Head of the Medicine Department, Jules Bordet Institute, Brussels, Belgium

Raphael E. Pollock, MD, PhD, FACS, Professor and Director, Division of Surgical Oncology, Surgeon in Chief, James Comprehensive Cancer Center, Surgeon in Chief, The Ohio State University Health System, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Ralph R. Weichselbaum, MD, Daniel K. Ludwig Professor Chair Dept of Radiology and Cellular Oncology University of Chicago Hospital Director Chicago Tumor Institute, IL, USA

Dr Hongyang Wang, Professor and Director, National Center for Liver Cancer, China; and Eastern Hepatobiliary Surgery Hospital, Shanghai, China

James F. Holland, MD, ScD (hc), Distinguished Professor of Neoplastic Diseases, Director Emeritus of Derald H.Rutttenberg Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Part 1: INTRODUCTION

1 Cardinal manifestations of cancer 00
James F. Holland, Waun K. Hong,DonaldW. Kufe, Robert C. Bast,William N. Hait, Raphael E. Pollock, and Ralph R.Weichselbaum

2 Biological hallmarks of cancer 00
Douglas Hanahan and Robert A.Weinberg

Part 2: TUMOR BIOLOGY

3 Technologies and Models to Study Cancer 00
Srinivas R. Viswanathan,David A. Tuveson, and Matthew Meyerson

4 Oncogenes 00
Marco A. Pierotti, Milo Frattini, Francesca Molinari, Gabriella Sozzi, and Carlo M. Croce

5 Tumor suppressor genes 00
David Cosgrove, Ben H. Park, and Bert Vogelstein

6 Epigenetic contributions to human cancer 00
James G. Herman and Stephen B. Baylin

7 Cancer genomics and evolution 00
William P.D. Hendricks, Aleksandar Sekulic, Alan H. Bryce, Muhammed Murtaza, Pilar Ramos, and Jeffrey M. Trent

8 Chromosomal Abberations in Human Cancer 00
David VanderWeele, Megan E. McNerney, and Michelle M. Le Beau

9 MicroRNA expression in cancer 00
Serge Patrick Nana-Sinkam, Mario Acunzo, and Carlo M. Croce

10 Aberrant signaling pathways in cancer 00
Luca Grumolato and Stuart A. Aaronson

11 Differentiation therapy 00
Sai-Juan Chen, Xiao-Jing Yan, Guang-Biao Zhou, and Zhu Chen

12 Cancer stem cells 00
Yadwinder S. Deol, Jill Granger, and Max S.Wicha

13 Cancer Cell Death 00
John C. Reed

14 Cancer cell immortality: targeting telomerase 00
Ilgen Mender, Zeliha Gunnur Dikmen,Woodring E. Wright, and Jerry W. Shay

15 Cancer metabolism 00
Natalya N. Pavlova and Craig B.Thompson

16 Modeling therapy of late or early-stage metastatic disease in mice 00
Robert S. Kerbel, Marta Paez-Ribes, Shan Man, Ping Xu, Eric Guerin,William Cruz-Munoz, and John M. L. Ebos

17 Tumor angiogenesis 00
John V. Heymach, Amado Zurita-Saavedra, Scott Kopetz, Tina Cascone, and Monique Nilsson

Part 3: QUANTITATIVE ONCOLOGY

18 Cancer bioinformatics 00
John N.Weinstein

19 Systems biology and genomics 00
Saima Hassan, Laura M. Heiser, and JoeW. Gray

20 Statistical innovations in cancer research 00
J. Jack Lee and Donald A. Berry

21 Biomarker-based clinical trial design in the era of genomic medicine 00
Richard Simon and Martine J. Piccart-Gebhart

22 Clinical informatics 00
Edward P. Ambinder

Part 4: CARCINOGENESIS

23 Chemical carcinogenesis 00
Lorne J. Hofseth, AinsleyWeston, and Curtis C. Harris

24 Endocrine and genetic bases of hormone-related cancers 00
Leslie Bernstein, Xia Pu, and Jian Gu

25 Ionizing radiation 00
David J. Grdina

26 Ultraviolet radiation carcinogenesis 00
James E. Cleaver, Susana Ortiz-Urda, Radhika Gulhar, Sarah Arron, Lionel Brookes, andDavid L. Mitchell

27 Inflammation and cancer 00
Jelena Todoric, Atsushi Umemura, Koji Taniguchi, and Michael Karin

28 RNA tumor viruses 00
Robert C. Gallo and Marvin S. Reitz

29 Herpesviruses 00
Jeffrey I. Cohen

30 Papillomaviruses and cervical neoplasia 00
Michael F. Herfs, Martin C. Chang, and Christopher P. Crum

31 Hepatitis viruses and hepatoma 00
HongyangWang

32 Parasites 00
Mervat Z. El Azzouni, and Radwa G. Diab

Part 5: EPIDEMIOLOGY, PREVENTION AND DETECTION

33 The burden of cancer worldwide: current and future perspectives 00
Jacques Ferlay, Christopher P.Wild, and Freddie Bray

34 Cancer epidemiology 00
XifengWu, Xia Pu, Stephanie C. Melkonian, and Margaret R. Spitz

35 Behavioral approaches to cancer prevention 00
Errol J. Philip and Jamie S. Ostroff

36 Diet and nutrition in the etiology and prevention of cancer 00
Steven K. Clinton, Elizabeth M. Grainger, and Edward L. Giovannucci

37 Chemoprevention of cancer 00
William N.William,Waun K. Hong, and Scott M. Lippman

38 Cancer Screening and Early Detection 00
OtisW. Brawley

Part 6: CLINICAL DISCIPLINES

39 Nexgen Pathology: Predicting clinical course and targeting disease causation 00
Carlos Cordon-Cardo and Adolfo Firpo-Betancourt

40 Molecular diagnostics in cancer 00
Roshni D. Kalachand, Bryan T. Hennessy, Robert C. Bast, and Gordon B. Mills

41 Principles of Conventional and Molecular Imaging 00
Lawrence H. Schwartz

42 Interventional Radiology for the Cancer Patient 00
Judy Ahrar, Michael J.Wallace, and Rony Avritscher

43 Principles of Surgical Oncology 00
Mark Bloomston, Donald L. Mortoni, Raphael E. Pollock, Michael Choti, and Ken K. Tanabe

44 Principles of radiation oncology 00
Philip P. Connell and Ralph R.Weichselbaum

45 Principles of Medical Oncology 00
William N. Hait, James F. Holland, Emil Frei III, Donald W. Kufe, Robert C. Bast Jr., andWaun KiHong

46 Palliative care 00
Cardinale B. Smith

47 Principles of psycho-oncology 00
Jimmie C. Holland and TaliaW.Wiesel

48 Principles of cancer rehabilitation medicine 00
Michael D. Stubblefield, David C. Thomas, and Kristjan T. Ragnarsson

49 Integrative oncology in cancer care 00
Gabriel Lopez, Richard Lee, Alejandro Chaoul, M. Kay Garcia, and Lorenzo Cohen

50 Health services research 00
Michaela A. Dinan, Bradford R. Hirsch, and Amy Abernethy

Part 7: INDIVIDUALIZED TREATMENT

51 Personalized Medicine in Oncology Drug Development 00
William N. Hait

Part 8: CHEMOTHERAPY

52 Preclinical and early clinical development of chemotherapeutic drugs, mechanism-based agents and biologics 00
Axel-R. Hanauske and Daniel D. Von Hoff

53 Tumor growth kinetics 00
Elizabeth Comen, Theresa A. Gilewski, and Larry Norton

54 Principles of Dose, Schedule, and Combination Chemotherapy 00
William N. Hait and Joseph P. Eder

55 Pharmacology 00
Manish R. Sharma and Mark J. Ratain

56 Folate Antagonists 00
Peter Cole and Joseph R. Bertino

57 Pyrimidine and purine antimetabolites 00
Robert B. Diasio

58 Alkylating agents and platinum antitumor compounds 00
Zahid H. Siddik

59 DNA topoisomerase targeting drugs 00
AnishThomas, Susan Bates,William D. Figg Sr, and Yves Pommier

60 Microtubule-Targeting Natural Products 00
Eric Rowinsky

61 Endocrine therapy for hormone receptor positive breast cancer 00
Aman U. Buzdar, Shaheenah Dawood, Harold A. Harvey, and V. Craig Jordan

62 Drug resistance and its clinical circumvention 00
Jeffrey A.Moscow, KennethH. Cowan, and Branimir I. Sikic

Part 9: BIOLOGICAL AND GENE THERAPY

63 Cytokines, interferons, and hematopoietic growth factors 00
Suhendan Ekmekcioglu and Elizabeth A. Grimm

64 Monoclonal serotherapy 00
Robert C. Bast, Michael R. Zalutsky, and Arthur E. Frankel

65 Vaccines and immunostimulants 00
Jeff Schlom

66 Cell-based cancer immunotherapy 00
Krina K. Patel, Judy S. Moyes, and Laurence J. Cooper

67 Cancer immunotherapy 00
Padmanee Sharma, Sumit K. Subudhi, Karl Peggs, Sangeeta Goswami, Jianjun Gao, Sergio Quezada, and James P. Allison

68 Cancer gene therapy 00
Haruko Tashiro and Malcolm Brenner

69 Cancer nanotechnology 00
Yanlan Liu, Danny Liu, Jinjun Shi, and Robert S. Langer

70 Hematopoietic cell transplantation 00
Roy Jones, Elizabeth Shpall, and Richard Champlin

Part 10: SPECIAL POPULATIONS

71 Principles of pediatric oncology 00
Teena Bhatla andWilliam L. Carroll

72 Cancer and pregnancy 00
Jennifer K. Litton

73 Cancer and aging 00
ArtiHurria,Hyman B. Muss, and Harvey J. Cohen

74 Disparities in Cancer Care 00
Otis Brawley

75 Immunoeffeciently related cancers 00
David T. Scadden and Jeremy S. Abramson

76 Cancer survivorship: new challenge in cancer medicine 00
Julia H. Rowland

Part 11: DISEASE SITES

77 Primary and metastatic neoplasms of the brain in adults 00
Lisa M. DeAngelis

78 Neoplasms of the eye 00
Jasmine H. Francis, Amy C. Schefler, and David H. Abramson

79 Neoplasms of the endocrine glands 00
Chirag D. Ghandi, Margaret Pain, and Kalmon Post

80 Neoplasms of the thyroid 00
Steven I. Sherman, Maria E. Cabanillas, and Stephen Lai

81 Neoplasms of the Adrenal Cortex 00
Tito Fojo

82 Tumors of the diffuse neuroendocrine and gastroenteropancreatic system 00
Evan Vosburgh

83 Neoplasms of the head and neck 00
Renata Ferrarotto, Merrill S. Kies, Adam S. Garden, and Michael E. Kupferman

84 Cancer of the Lung 00
Charles Lu, Daniel Morgensztern, Anne Chiang, Amir Onn, Boris Sepesi, Ara A. Vaporciyan, Joe Y. Chang, Ritsuko Komaki, Ignacio I. Wistuba, and Roy S. Herbst

85 Malignant pleural mesothelioma 00
Daniel R. Gomez, Anne S. Tsao, Haining Yang, and Harvey I. Pass

86 Thymomas andThymic Tumors 00
Alberto Marchevsky and Ronan Kelly

87 Tumors of the heart and great vessels 00
Anthony F. Yu, Sai-Ching J. Yeung, Carmen P. Escalante, Sarina van der Zee, A. P. Chahinian, and Valentin Fuster

88 Primary germ cell tumors of the thorax 00
John D. Hainsworth and F. Anthony Greco

89 Neoplasms of the Esophagus 00
MaxW. Sung, Virginia R. Litle, Steven J. Chmura, Stephen G. Swisher, David C. Rice, Jaffer A. Ajani, Ritsuko K. Komaki, andMark K. Ferguson

90 Carcinoma of the Stomach 00
Carl Schmidt, Mariela Blum Murphy, James C. Yao, and Christopher Crane

91 Primary neoplasms of the liver 00
Junichi Shindoh, KristofferW. Brudvik, and Jean-Nicolas Vauthey

92 Gallbladder and Bile Duct Cancer 00
Ahmed O. Kaseb, Melanie B. Thomas, Steven A. Curley

93 Neoplasms of the Exocrine Pancreas 00
Robert A.Wolff, Christopher H. Crane, Donghui Li, Douglas B. Evans, AnirbanMaitra, and Susan Tsai

94 Neoplasms of the colon, small intestine, vermiform appendix and peritoneum 00
Doug Tyler and Georgia Beasley

95 Neoplasms of the anus 00
Bruce D. Minsky and Jose G. Guillem

96 Renal cell carcinoma 00
Earle F. Burgess, Stephen B. Riggs, Brian I. Rini, and Derek Raghavan

97 Urothelial Cancer 00
Derek Raghavan, Richard Cote, Earle F. Burgess, Stephen B. Riggs, and Michael Haake

98 Neoplasms of the Prostate 00
Christopher J. Logothetis, Jeri Kim, JohnW. Davis, Brian F. Chapin, Deborah Kuban, Eleni Efstathiou, and Ana Aparicio

99 Tumors of the penis and urethra 00
Raymond Lance and Michael B.Williams

100 Testis cancer 00
Craig Nichols, Lawrence Einhorn, and Christian Kollmannsberger

101 Cancer of the vulva and vagina 00
Jacob Rotmensch and Summer Dewdney

102 Neoplasms of the cervix 00
Anuja Jhingran

103 Endometrial cancer 00
Jamal Rahaman, Karen Lu, and Carmel J. Cohen

104 Epithelial ovarian, fallopian tube, and peritoneal cancer 00
Jonathan S. Berek, Michael L. Friedlander, Robert C. Bast Jr.

105 Nonepithelial Ovarian Malignancies 00
Jonathan S. Berek, Michael L. Friedlander, and Robert C. Bast

106 Molar pregnancy and gestational trophoblastic neoplasia 00
Donald P. Goldstein, Ross S. Berkowitz, and Neil S. Horowitz

107 Gynecologic sarcomas 00
Jamal Rahaman and Carmel J. Cohen

108 Neoplasms of the Breast 00
Hope Rugo

109 Malignant Melanoma 00
Kim Margolin, Vernon Sondak, Susan Swetter, Scott Woodman, Jonathan Zager and Justin Ko

110 Other skin cancers 00
William G. Stebbins, Eric A. Millican, and Victor A. Neel

111 Bone Tumors 00
Tim Damron

112 Soft Tissue Sarcomas 00
Robert G. Maki, Chandrajit P. Raut, and Brian OffkSullivan

113 The Myelodyplastic Syndrome 00
Lewis R. Silverman

114 Acute Myeloid Leukemia in Adults: Mast Cell Leukemia and Other Mast Cell Neoplasms 00
Charles A. Schiffer and Richard Stone

115 Chronic myeloid leukemia 00
Jorge Cortes, Richard T. Silver, and Hagop M. Kantarjian

116 Acute lymphoblastic leukemia 00
Nitin Jain, Stefan Faderl, Hagop Kantarjian, and Susan O'Brien

117 Chronic Lymphocytic Leukemia and Hairy Cell Leukemia 00
Kanti R. Rai and Jacquie Barrientos

118 Hodgkin lymphoma 00
Carol S. Portlock, Anita Kumar, and James Armitage

119 Non-Hodgkin Lymphoma 00
Arnold S. Freedman and Ann S. LaCasce

120 Mycosis fungoides and Sèzary syndrome 00
Richard T. Hoppe, Youn H. Kim, and Ranjana H. Advani

121 Plasma Cell Tumors 00
Kenneth C. Anderson

122 Myeloproliferative Neoplasms: Essential Thrombocythemia, Primary Myelofibrosis and Polycythemia Vera 00
AyalewTefferi

123 Neoplasms of Unknown Primary Site 00
John D. Hainsworth and F. Anthony Greco

Part 12: MANAGEMENT OF CANCER COMPLICATIONS

124 Anorexia and cachexia 00
Takao Ohnuma

125 Antiemetic Therapy 00
Patrick M. Forde, David S. Ettinger

126 Neurologic complications of cancer 00
Lisa M. DeAngelis

127 Dermatologic Complications of Cancer Chemotherapy 00
Anisha B. Patel and Madeleine M. Duvic

128 Skeletal complications 00
Michael A. Via, Ilya Iofin, and Jeffrey I. Mechanick

129 Hematologic complications and blood bank support 00
Richard M. Kaufman and Kenneth C. Anderson

130 Coagulopathic complications of cancer patients 00
Maria T. De Sancho and Jacob H. Randa

131 Urologic complications 00
Rachel A. Sanford, Ala Abudayyeh, Christopher J. Logothetis, andNizar M. Tannir

132 Cardiac Complications 00
Michael S. Ewer

133 Respiratory Complications 00
Vickie R. Shannon, George A. Eapen, Carlos A. Jimenez, Rodolfo C. Morice, Elizabeth L. Travis, Lara Bashoura, Scott E. Evans, Roberto Adachi, Saadia A. Faiz, Diwakar

D. Balachandran, S. Egbert Pravinkumar, Burton F. Dickey, Horiana B. Grosu, andMichaelH. Kroll

134 Gastrointestinal and hepatic complications in cancer patients 00
Robert S. Bresalier, H. Franklin Herlong, and Boris Blechacz

135 Oral complications of cancer and their treatment 00
Stephen T. Sonis and Anna Yuan

136 Gonadal complications 00
Vignesh Narayanan and Catherine E. Klein

137 Sexual dysfunction 00
Leslie R. Schover

138 Endocrine complications and paraneoplastic syndromes 00
S. JimYeung and Robert F. Gagel

139 Infections in patients with cancer 00
Lior Nesher and Kenneth V.I. Rolston

140 Oncologic emergencies 00
Sai-Ching Jim Yeung and Carmen P. Escalante

Part 13: THE FUTURE OF ONCOLOGY

141 A vision for 21st century healthcare 00
Leroy Hood, Kristin Brogaard, and Nathan D. Price