Handbook of Mental Health and Aging

Dr. Nathan Hantke is assistant professor in the Department of Neurology at Oregon Health and Science University and a board certified clinical neuropsychologist with experience assessing cognitive problems in adults across a wide range of diagnoses, including memory disorders, head injury, movement disorders, and epilepsy. His primary research interests are in geriatric neuropsychology, and he has authored multiple peer-reviewed publications and book chapters examining late-life cognitive decline and related risk factors. In addition to his clinical and research roles, he also serves as the national Co-Director for the VA’s 27-site research fellowship program in mental illness research and treatment. Amit Etkin, MD, PhD, is an Associate Professor of Psychiatry and Behavioral Sciences at Stanford University, a member of the Stanford Neurosciences Institute, and an Investigator in the VA Sierra-Pacific Mental Illness Research Education and Clinical Center (MIRECC) at the Palo Alto VA. Dr. Etkin is trained as both as a neuroscientist and psychiatrist. The overarching aim of the Etkin lab is to understand the neural basis of emotional disorders and their treatment, and to leverage this knowledge to better understand how the brain works and to develop novel treatment interventions. In support of this goal, Dr. Etkin also collaborates with neuroscientists, engineers, psychologists, physicians and others to establish a new intellectual, scientific and clinical paradigm for understanding and manipulating human brain circuits in healthy individuals and for treating psychiatric disease. Dr. Ruth O’Hara is an Associate Chair and Associate Professor in the Department of Psychiatry and Behavioral Sciences and Director of the Translational Research Core of the Veterans Affairs Sierra-Pacific Mental Illness Research Education and Clinical Center (MIRECC). Her research focuses on longitudinal investigations of the relationship between neurocognitive and neuropsychiatric symptoms in normal and pathological aging. She served on the DSM 5 Sleep Wake Workgroup, and was a member of the national VA Dementia Guidelines Committee. Her current research has a primary emphasis on the impact of sleep disordered breathing, sleep apnea and associated hypoxia on psychiatric symptoms and cognitive function in older adults. She has extensive experience conducting full ambulatory polysomnography in a broad range of late life disorders, with hundreds of such studies conducted in her laboratory to date.

List of Contributors Preface

1. Concepts and Issues in Mental Health and Aging Nathan Hantke and Ruth O'Hara

2. Epidemiology of Selected Mental Disorders in Later Life Brenna N. Renn, Patricia A. Arean and Jurgen Unutzer

3. Culture and Ethnicity in the Mental Health of Older Adults Lucas Torres, Claire Bird and Felicia Mata-Greve

4. Stress, Mental Health, and Aging Raeanne C. Moore, Elizabeth Straus and Laura M. Campbell

5. Structural Changes in the Aging Brain Meghan Riddle and Warren D. Taylor

6. Sleep-Dependent Cellular Chemical Changes in the Aging Brain Gordon X. Wang and Philippe Mourrain

7. Biomarkers of Cognitive Impairment in Late-Life Depression Breno S. Diniz and Meryl A. Butters

8. Accelerated Brain Molecular Aging in Depression Rammohan Shukla and Etienne Sibille

9. Cognitive Dysfunction in Late-Life Psychiatric Disorders: Phenotypes, Risk Factors, and Treatment Targets Christina F. Chick, Casey Buck and Ruth O'Hara

10. Suicide in Late Life Joshua T. Jordan and Lauren A. Anker

11. Anxiety and its Disorders in Old Age Sherry A. Beaudreau, Christine E. Gould, Susan Sharp Kolderup and Nehjla Mashal

12. Bipolar Disorders in Older Adults Laura Hein, Annemiek Dols and Lisa T. Eyler

13. Positive Psychiatry and Successful Aging in People with Schizophrenia Dilip V. Jeste, Ryan Van Patten and Ellen E. Lee

14. Alzheimer's Disease and Other Neurocognitive Disorders Lucy Y. Wang, Beth Ann LaBardi, Murray A Raskind and Elaine R Peskind

15. Substance Use Disorders in the Elderly Tylor J. Jilk and Martin S. Mumenthaler

16. Sleep Disorders and Aging Logan Schneider, Rosy Karna, Makoto Kawai and Kai Parker-Fong

17. Aging of Persons with Neurodevelopmental Disabilities Lauren A. Anker, Christina F. Chick and Joachim F. Hallmayer

18. Bereavement and Grief Danielle K. Florioso, Alana Iglewicz and Sidney Zisook

19. Neuropsychology with Older Adults Nathan Hantke and Nicholas T. Bott

20. Integrative Precision-Medicine Approach to Cognitive Assessment in Older Adults Sharon Naparstek, Omer Linkovski and Limor Gertner

21. Functional Assessment in Geriatric Mental Health Adriana Seelye, Sarah Brown, Katherine Dorociak, Jeffrey Kaye, Katherine Wild and Snezana Urosevic

22. Psychotherapeutic Interventions with Older Adults: Now and Into the Future Leander K. Mitchell and Nancy A. Pachana

23. Psycopharmacologic Treatment Vimal M. Aga, Mujeeb U. Shad, Hongru Zhu and Carl Salzman

24. Technology-Based Mental Health Assessment and Intervention Christine E. Gould, Flora Ma, Julia R. Loup, Christine Juang, Erin Y. Sakai and Renee Pepin

25. Community and Home Care for Mentally Ill Older Adults Erin Cassidy-Eagle

26. Forensic and Ethical Issues Mousa S. Botros, Julie E. Guzzardi, Regina M. Carney, Spencer Eth and Gregory B. Leong

27. The Economics of Geriatric Mental Health Care Nicholas T. Bott

28. The Future of Mental Health and Aging Nathan Hantke, Ruth O'Hara, Sherry A. Beaudreau and Amit Etkin

Author Index Subject Index