Recurrent Pregnancy Loss

Prof. Carp studied Medicine at Charing Cross Hospital Medical School in London. He completed his training for the MRCOG in the UK. He has since worked at the Sheba Medical Center, Tel Hashomer, in Israel, and has held a Senior Lecturer post in Embryology at Tel Aviv University. He is Professor of Obstetrics and Gynaecology at Tel Aviv University. He has many clinical interests, including ectopic pregnancy, implantation, and infertility. He has edited two other books: The Infertility Manual and Principles and Practice of Assisted Reproductive Technology. Another book, Progestogens in Gynecological Practice is in press. He has published over 70 original research articles, 16 review articles and 6 chapters in books and has been invited to lecture in many parts of the world. Prof. Carp has taken a special interest in recurrent miscarriage, other forms of pregnancy loss, and infertility in general.

The Epidemiology of Recurrent Pregnancy Loss; Ole B. Christiansen


Signaling between Embryo and Mother in Early Pregnancy: Basis for Development of Tolerance; Eytan R. Barnea


Genetics of Spontaneous Abortions; Joe Leigh Simpson


Debate: Should Fetal Karyotyping be Performed in Recurrent Pregnancy Loss? Yes; Howard J. A. Carp


Debate: Should Fetal Karyotyping be Performed in Recurrent Pregnancy Loss? No; Zvi Borochowitz


Debate: Should Preimplantation Genetic Screening be Performed in Recurrent Pregnancy Loss? Yes; Pere Mir, Nasser Al-Asmar, Lorena Rodrigo, Carlos Simon, and Carmen Rubio


Debate: Should Preimplantation Genetic Screening or Preimplantation Genetic Diagnosis be Performed in Recurrent Pregnancy Loss? No; Anna M. Musters and Mariette Goddijn


Debate: Screening for Chromosomal Aberrations in Recurrent Pregnancy Loss: Nonspecific Testing is Sufficient; Howard Cuckle


Debate: Screening for Chromosomal Aberrations in Recurrent Pregnancy Loss: Noninvasive Prenatal Testing, Cytogenetics and Ultrasound are Needed; Peter Benn


Does the Maternal Immune System Regulate the Embryo’s Response to External Toxins? Arkady Torchinsky, Vladimir Toder, Shoshana Savion, and Howard J. A. Carp


Fetal Structural Malformations—Embryoscopy; Thomas Philipp


Fetal Structural Malformations—Ultrasound; Akhila Vasudeva and Pratap Kumar


Endocrinology of Pregnancy Loss; N. Pluchino, P. Drakopoulos, J. M. Wenger, S. Luisi, M. Russo, and A. R. Genazzani


Debate: Should Progesterone Supplements be Used? Yes; Jerome H. Check


Debate: Should Progesterone Supplements be Used? No; Aisha Hameed, Shazia Malik, and Lesley Regan


Opinion: Progestogens in Recurrent Miscarriage; Howard J. A. Carp


Debate: Should Human Chorionic Gonadotropin Supplementation be Used? Yes; James Walker


Debate: Should Human Chorionic Gonadotropin Supplementation be Used? No; Harish M. Bhandari and Siobhan Quenby


Antiphospholipid Syndrome—Pathophysiology; Rotem Inbar, Miri Blank, and Yehuda Shoenfeld


Diagnosis of Antiphospholipid Antibody-Associated Abortions; Marighoula Varla-Leftherioti


Management of Antiphospholipid Syndrome in Pregnancy; Alana B. Levine and Michael D. Lockshin


Defects in Coagulation Factors Leading to Recurrent Pregnancy Loss; Aida Inbal and Howard J. A. Carp


Debate: Should Thromboprophylaxis be Used in Hereditary Thrombophilias with Recurrent Pregnancy Loss? Yes; Benjamin Brenner


Debate: Should Thromboprophylaxis be Used in Hereditary Thrombophilias with Recurrent Pregnancy Loss? No; Pelle G. Lindqvist


Opinion: Can Recurrent Pregnancy Loss be Prevented by Antithrombotic Agents? Howard J. A. Carp


Uterine Anomalies and Recurrent Pregnancy Loss; Daniel S. Seidman and Mordechai Goldenberg


The Immunobiology of Recurrent Miscarriage; Marighoula Varla-Leftherioti


Debate: Should Immunotherapy be Used? Lymphocyte Immunization Therapy: Yes; Edward E. Winger and Jane L. Reed


Debate: Should Immunotherapy be Used? Intravenous Immunoglobulin: Yes; Carolyn B. Coulam


Debate: Should Immunotherapy be Used? Granulocyte colony stimulating factor: Yes; Fabio Scarpellini and Marco Sbracia


Debate: Should Immunotherapy be Used? No; Raj Rai


Autoimmunity and Recurrent Pregnancy Loss; Sonia Zatti, Andrea Lojacono, and Angela Tincani


Infections and Recurrent Pregnancy Loss; David Alan Viniker


The Male Factor in Recurrent Pregnancy Loss and Embryo Implantation Failure; Richard Bronson


Midtrimester Loss: The Role of Cerclage and Pessaries; Israel Hendler and Howard J. A. Carp


Midtrimester Loss and Viability; Flora Y. Wong and Victor Y. H. Yu


Obstetric Outcomes after Recurrent Miscarriage; Howard J. A. Carp


Coping with Repeated Pregnancy Loss: Psychological Mechanisms; Keren Shakhar


Methodological Issues in Evidence-Based Evaluation of Treatment for Recurrent Miscarriage; Salim Daya


Investigation Protocol for Recurrent Pregnancy Loss; Howard J. A. Carp


A New Algorithm for Evaluation and Treatment of Recurrent Pregnancy Loss; William H. Kutteh, Raymond W. Ke, and Paul R. Brezina


Third Party Reproduction in Recurrent Pregnancy Loss; Gautam N. Allahbadia and Rubina Merchant


"Slippery Fetus": Recurrent Pregnancy Loss in Traditional Chinese Medicine; Aviv Messinger and Keren Sela


A Patient’s Perspective; Mindy Gross


Epilogue; Howard J. A. Carp


Index