Aging and Heart Failure (eBook)

Mechanisms and Management

Bodh I. Jugdutt (Herausgeber)

eBook Download: PDF
2014 | 2014
XXII, 475 Seiten
Springer New York (Verlag)
978-1-4939-0268-2 (ISBN)

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This book synthesizes the major research advances in molecular, biochemical and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists and internists.
This book synthesizes the major research advances in molecular, biochemical and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists and internists.

Ch. 1: Changing demographics of the aging population with heart failure and implications for therapy            Bodh I. JugduttCh. 2: Biology of aging and implications for heart failure therapy and prevention            Bodh I. JugduttCh. 3: Hypertension and prevention of diastolic heart failure in the aging population            Wilbert S. AronowMaciej BanachAli AhmedCh. 4: Aging and optimal therapy of systolic heart failure in the elderly            Nakul Chander SharmaBodh I. Jugdutt Ch. 5: Atrial fibrillation and heart failure in the aging population            Pedram KazemianBodh I. JugduttCh. 6: Optimizing therapy of heart failure in the aging population with monitoring in clinics            John R. DimitryJustin A. EzekowitzCh. 7:  Cardiac alterations in aging, hypertension and diastolic heart failure            Edith PituskinD. Ian PatersonCh. 8: Polypharmacy and adverse drug reactions in the aging population with heart failure            Michael W. RichWilliam J. NienaberCh. 9: Aging-related changes in vascular biology and implications for heart failure therapy in the aging population            Michael Sean McMurtryCh. 10: Biomarkers and optimal management of heart failure in the aging population            Hanna K. Gaggin James L. Januzzi, Jr.Ch. 11: Benefits of Exercise in the elderly            Ezra A. AmsterdamC. Tissa KappagodaCh. 12: The RAAS in heart failure: an update on clinical trials and opportunities for therapy            C. Tissa KappagodaEzra A. AmsterdamCh. 13: Aging and diastolic dysfunction – the interplay of inflammation and extracellular matrix regulation                     Peter Moritz BecherDirk Westermann,Carsten TschöpeCh. 14: Reperfusion and vasodilator therapy in elderly patients with STEMI and heart failure. Improving outcomesBodh I. Jugdutt, Anwar JelaniSeraj AbualnajaNakul Chander SharmaJoseph Szeman WongCh. 15: Erythropoietin therapy for heart failure            Margarita BorovkaMathew S. MaurerCh. 16: Role of resistin in heart failure in the elderly            Yasuchika TakeishiCh. 17: Role of coronary artery calcium in cardiovascular risk stratification and management in the aging population            Craig R. ButlerPaolo RaggiCh. 18: Aging-and remodeling of the RAS and RAAS and related pathways. Implications for heart failure therapyBodh I. JugduttCh. 19: Aging and right ventricular failure from pulmonary hypertension: Effect of right ventricular and pulmonary artery remodelingJoseph Szeman WongBodh I. JugduttCh. 20: Biomarkers of cardiovascular aging           Nirankar S. NekiParamjit S. TappiaNaranjan S. DhallaCh. 21: Changes in the heart that accompany advancing age: Humans to molecules            Edward G. LakattaHarold A. SpurgeonAndzej M. JanczewskiCh. 22: Aging-related changes in cell death and cell survival pathways and implications for heart failure therapy            Guido R.Y. De MeyerDorien M. SchrijversWim MartinetCh. 23: Aging-related changes in telomeres and telomerases and implications for heart failure therapy            Pim van der HarstDirk J. van VeldhuisenCh. 24: Aging associated alterations in myocardial inflammation and fibrosis: pathophysiological perspectives and clinical implications            Arti V. ShindeNikolaos G FrangogiannisCh. 25: Aging-related changes in extracellular matrix: implications for ventricular remodeling following myocardial infarction              Nguyen T. NguyenAndriy YabluchanskiyLisandra E. de Castro BrásYu-Fang JinMerry L. LindseyCh. 26: Calcium handling defects and changes in cardiac function in the aging heart            Adriana AdameovaNirankar S. NekiParamjit S. TappiaNaranjan S. DhallaCh. 27: Integrins: Implications for aging in heart failure therapy            Laura L. DanielWilliam L. JoynerMahipal SinghKrishna SinghCh. 28: Adipokines as novel biomarkers in aging and heart failure            Ken ShinmuraCh. 29: Aging-related changes in cellular and molecular mechanisms of post-infarction remodeling. Implications for heart failure therapy            Henry Han-Jen ShihAndrew J. BoyleCh. 30: Aging-related changes in mitochondrial function and implication for heart failure therapy            Satoaki MatobaAtsushi HoshinoHiroaki MatsubaraCh. 31: Regulation of SERCA via oxidative modifications: Implications for the pathophysiology of diastolic dysfunction in the aging heart            Fuzhong QinRichard A. CohenWilson S. ColucciCh. 32: SMP-30 and aging-related cardiac remodeling and heart failure            Satoshi SuzukiYasuchika Takeishi

Erscheint lt. Verlag 19.2.2014
Zusatzinfo XXII, 475 p. 84 illus., 50 illus. in color.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Geriatrie
Medizinische Fachgebiete Innere Medizin Kardiologie / Angiologie
Schlagworte aging • Heart Failure • Myocardial Infarction • systolic heart failure
ISBN-10 1-4939-0268-7 / 1493902687
ISBN-13 978-1-4939-0268-2 / 9781493902682
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