The Biology of Glycoproteins

Buch | Softcover

449 Seiten

2012 | Softcover reprint of the original 1st ed. 1984
Springer-Verlag New York Inc.
978-1-4684-7466-4 (ISBN)

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This book is in many ways a sequel to The Biochemistry ojGlycoproteins and Proteoglycans. The enormous recent progress in understanding the biological roles of glycoproteins has prompted the present volume. The reasons for studying glycoproteins have multiplied, and in the present volume the roles played by glycoproteins are explored in a variety of biological situations. The first two chapters describe molecules involved in cell-substratum and cell-cell interactions in a broad sense, and also focus on recent progress in identifying specific attachment molecules. Our understanding of how normal processes, such as cellular differentiation and tissue organization, are regulated is dependent on understanding how cells interact with the extracellular matrix. When these processes go awry the consequences can be tragic, for example, when manifest as birth de fects and cancer. Our ability to devise appropriate therapies is in many cases limited by our understanding of such cell-matrix interactions. The third chapter explores the roles by glycoproteins during early mammalian development. The carbohydrate portions c1early play very important roles in presenting information during early embryogenesis, and an unusual tumor stern cell, the embryonal carcinoma, looks very promising in pro viding an experimental system for understanding how the expression of these complex carbohydrate determinants is regulated. The next three chapters explore the biology of glycoproteins in distinct situations: in the immune system, in the nervous system, and during erythropoiesis.

1 Integral Membrane Glycoproteins in Cell-Cell and Cell-Substratum Adhesion.- 1. Introduction.- 2. Cell-Cell Adhesion.- 3. Cell-Substratum Adhesion.- References.- 2 Attachment Proteins and Their Role in Extracellular Matrices.- 1. Composition and Structure of Extracellular Matrices.- 2. Cell Interactions with Collagen.- 3. Role of Extracellular Matrix and Attachment Proteins in Development.- 4. Attachment Proteins in Pathological Conditions.- 5. Summary.- References.- 3 Role of Glycoproteins during Early Mammalian Embryogenesis.- 1. Introduction.- 2. Role of Glycoproteins during Ferilization.- 3. Role of Glycoproteins during Preimplantation Development.- 4. Regulation of Glycoprotein Biosynthesis in Early Embryonic Cells.- 5. Formation of Endoderm and Assembly of Early Basement Membranes.- 6. Conclusions.- References.- 4 Cell Surface Glycoproteins and Carbohydrate Antigens in Development and Differentiation of Human Erythroid Cells Minoru Fukuda.- 1. Introduction.- 2. Cell Surface Glycoproteins and Carbohydrate Structure of Mature Erythrocytes.- 3. Developmental Changes in Carbohydrate Structure.- 4. Changes in Cell Surface Glycoproteins and Carbohydrate Antigens during Erythropoiesis.- 5. Cell Surface Markers in in Vitro Differentiation of Leukemic Cells.- 6. Cell Surface Markers in Hematological Disorders.- 7. Concluding Remarks and Prospects.- References.- 5 Carbohydrate Structure, Biological Recognition, and Immune Function Christopher.- 1. Introduction.- 2. Carbohydrate-Binding Proteins in the Immune System.- 3. Differentiation Antigens in the Immune System.- 4. Carbohydrate-Mediated Recognition in Cellular Interactions.- 5. Conclusions and Future Directions.- References.- 6 Nervous System Glycoproteins: Molecular Properties and Possible Functions.- 1. Introduction.- 2. Structure and Composition of Glycoprotein Oligosaccharides in the Nervous System.- 3. Glycoproteins of Synaptic Membranes and Synaptic Junctions.- 4. Cell Surface Glycocomponents of Cultured Neurons: Distribution and Dynamics of Lectin Receptors at the Growth Cone.- 5. Cell Surface Glycoproteins: Involvement in Cell-Cell Recognition and Adhesion.- 6. Brain Cell Surface Glycocomponents Involved in Growth Inhibition.- 7. Glycoproteins of Synaptic Vesicles and Secretory Organelles.- 8. Glycoproteins Involved in Neurotransmission.- 9. Glycoproteins of Central and Peripheral Nervous System Myelin.- 10. Concluding Remarks.- References.- 7 The Role of Glycoproteins in the Life Cycle of the Cellular Slime Mold Dictyostelium discoideum.- 1. Introduction.- 2. Developmental Regulation of Glycoproteins.- 3. Regulation of Glycoprotein Biosynthesis.- 4. Synthesis and Processing of Glycoprotein-Linked Oligosaccharides.- 5. Glycoprotein Roles in Vegetative Cells.- 6. Developmental Regulation of Cellular Cohesion.- 7. The Slime Sheath.- 8. Glycoproteins Specific for Prestalk or Prespore Cells.- 9. Concluding Remarks.- References.

Zusatzinfo	XIV, 449 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	152 x 229 mm
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
ISBN-10	1-4684-7466-9 / 1468474669
ISBN-13	978-1-4684-7466-4 / 9781468474664
Zustand	Neuware