Wnt Signaling in Development and Disease (eBook)

Stefan P. Hoppler, PhD, is Professor in Developmental Biology at the School of Medical Sciences at the University of Aberdeen. In addition to his teaching duties Prof. Hoppler runs research programs looking at Wnt inhibitors in heart muscle differentiation and tissue-specific regulation of gene expression by Wnt/beta-catenin signalling, and he also serves on the editorial board for the journal Developmental Dynamics. Randall T. Moon, PhD, is Professor of Pharmacology at the University of Washington School of Medicine. His lab focuses on identifying the normal roles of Wnt signaling in embryos and adults and applying that knowledge to develop therapies for acute and chronic medical conditions involving Wnt signaling. Dr. Moon is Founding Director of the University of Washington Institute for Stem Cell and Regenerative Medicine, and a member of the Paul Allen Brain Institute Cell Networks Advisory Council, the HHMI Medical Research Fellows Program panel, and College of CSR Reviewers for NIH.

1 Wnt signal production, secretion and diffusion
Madelon M. Maurice and Hendrik C. Korswagen

2 Wnt signaling at the membrane
Gary Davidsonand Christof Niehrs

3 Wnt signal transduction in the cytoplasm: an introduction to the destruction complex
Tony W. Chen, Heather A. Wallace, Yashi Ahmed and Ethan Lee

4 An overview of gene regulation by Wnt/b-catenin signaling
Chen U. Zhang and Ken M. Cadigan

5 Finding a Needle in a Genomic Haystack: Genome-wide Approaches to Identify Wnt/TCF Transcriptional Targets
Chandan Bhambhani and Ken M. Cadigan

6 Introduction to b-catenin independent Wnt signaling pathways
Susanne Kuhl and Michael Kuhl

7 Molecular mechanisms of Wnt pathway specificity
Alexandra Schambony, Guido J.R. Zaman, Folkert Verkaar

8 Modulation of Wnt signaling by endocytosis of receptor complexes
Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, Akira Sato

9 New insights from proteomic analysis of WNT signaling
Matthew P. Walker, Dennis Goldfarband Michael B. Major

10 New insights about Wnt pathway mechanisms from global siRNA screens
Tenzin Gocha and Ramanuj DasGupta

11 Mathematical models of Wnt signaling pathways
Michael Kuhl, Barbara Kracher, Alexander Gross, and Hans Kestler

12 The Wnt's tale: On the evolution of a signaling pathway
Jenifer C. Croce and Thomas W. Holstein

13 Secreted Wnt inhibitors or modulators
Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve and Herbert Steinbeisser

14 Frizzleds as G protein-coupled receptors
Gunnar Schulte

15 Dishevelled, at the crossroads of pathways
Vitezslav Bryja and Ondrej Bernatik

16 ß-catenin: a key player in both cell adhesion and wnt signaling
Jonathan Pettitt

17 Evolutionary Diversification of vertebrate TCF/LEF structure, function, and regulation
Stefan Hoppler and Marian L. Waterman

18 Insights from Structural Analysis of Protein-protein Interactions by Wnt Pathway Components and Functional Multi-protein Complex Formation
Zhihong Cheng and Wenqing Xu

19 Wnt signaling in early vertebrate development: from fertilization to gastrulation
Eliza Zylkiewicz, Sergei Y. Sokol and Stefan Hoppler

20 Wnt/ß-catenin Signaling in Embryonic Stem Cells: Insights into Early Mammalian Development
Kathryn C. Davidson

21 Wnt Signaling Specifying Neural Lineages
Richard Dorsky

22 Wnt signaling in Heart Organogenesis
Stefan Hoppler, Silvia Mazzotta and Michael Kühl

23 Wnt signaling in kidney organogenesis
Kimmo Halt and Seppo Vainio

24 Wnt signaling regulation of tissue architecture (EMT and MET) and morphogenesis: consequences for Colorectal and Liver Cancer
T Fifis, BM Tran BM, RHM Schwab, TM Johanson, N Warner, N Barker, E Vincan

25 Wnt signaling in adult stem cells: tissue homeostasis and regeneration
Frank J.T. Staal and Riccardo Fodde

26 Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury
Gunes Ozhan and Gilbert Weidinger

27 Wnt Signaling and colorectal cancer
Kevin Myant and Owen J Sansom

28 Wnt signaling in melanoma
Jamie N. Anastas and Andy J. Chien

29 Wnt Signaling in Mood & Psychotic Disorders
Stephen J. Haggarty, Karun Singh, Roy H. Perlis, Rakesh Karmacharya

30 Neuropsychiatric Disease-associated Genetic Variation in the Wnt Pathway
Stephen J. Haggarty, Karun Singh, Roy H. Perlis, Rakesh Karmacharya

31 Wnt Signaling in Dementia
Stephen J. Haggarty

32 Therapeutic targeting of the Wnt signaling network
Felicity Rudge and Trevor Dale