Psychobiological Approaches for Anxiety Disorders (eBook)

Stefan G. Hofmann is Professor of Psychology at Boston University and the Director of the Psychotherapy and Emotion Research Laboratory. The incoming President of the Association for Behavioral and Cognitive Therapies, he is widely published with more than 200 peer-reviewed journal articles and book chapters, and 10 books, including An Introduction to Modern CBT (2011, Wiley-Blackwell).

About the Contributors vii

About the Editor xi

Introduction 1

Stefan G. Hofmann

Chapter 1 The Biology and Efficacy of Combination Strategies for
Anxiety Disorders 5

Keith A. Ganasen and Dan J. Stein

Chapter 2 Benzodiazepines 25

Bridget A. Hearon and Michael W. Otto

Chapter 3 Tricyclic Antidepressants and Monoamine Oxidase
Inhibitors 41

Franklin R. Schneier

Chapter 4 Selective Serotonin Reuptake Inhibitors, Reversible
Inhibitors of Monoamine Oxidase-A, and
Buspirone 61

Borwin Bandelow, Markus Reitt, and Dirk Wedekind

Chapter 5 D-Cycloserine 75

Adam J. Guastella and Gail A. Alvares

Chapter 6 Yohimbine Hydrochloride 91

Samantha G. Farris, Michelle L. Davis, Lindsey B. DeBoer, Jasper
A. J. Smits, and Mark B. Powers

Chapter 7 Cortisol 109

Leila Maria Soravia and Dominique J.-F. de Quervain

Chapter 8 Oxytocin 123

Markus Heinrichs, Frances S. Chen, and Gregor Domes

Chapter 9 Dietary Supplements 145

Lindsey B. DeBoer, Michelle L. Davis, Mark B. Powers, and Jasper
A. J. Smits

Chapter 10 A Roadmap for the Research and Practice of
Combination Strategies 181

Stefan G. Hofmann

Index 195

There are two major treatment approaches for anxiety and its
disorders: psychological and pharmacological. But for too long
these treatment approaches have been administered like ships
passing in the night with little or no useful information available
on when or why they should be integrated and combined. Now Stefan
Hofmann in a groundbreaking edited volume gives this topic the
broadest and deepest coverage it has yet enjoyed looking at current
evidence and possible mechanisms of action involved in integrating
not only the major compounds such as benzodiazepines and selective
serotonin re-uptake inhibitors (SSRIs) with psychological
treatments, but also some of the newer compounds such as
D-cycloserine and oxytocin. Ending with a road map for the future,
this volume should be on the shelf of every clinician and clinical
investigator working on the problem of pathological anxiety.

--David H. Barlow, Professor of Psychology
and Psychiatry, Founder and Director Emeritus, Center for Anxiety
and Related Disorders, Boston University



Internationally recognized research psychologist, Stefan
Hofmann, has brought together leading experts on the neuroscience,
effectiveness, and clinical use of biological treatments for the
major anxiety disorders. This volume - Psychobiological
Approaches for Anxiety Disorders - is a seminal book
and a remarkable achievement. Each chapter provides a clear,
scholarly review of the research on medications and even the use of
dietary supplements in combination with CBT, or alone. This unique
volume will become the standard reference for anyone seriously
interested in the important question of whether combination
treatments are helpful and - if they are or are not -
why this is the case. A major contribution to the field, I think
that all researchers and informed clinicians will want to read this
book.

--Robert L. Leahy, Clinical Professor of
Psychology, Weill-Cornell University Medical School and Director,
American Institute for Cognitive Therapy