Germinal Centers in Immune Responses

Comparison of Existing Theories on the Function of Germinal Centers.- Discussion.- Session 1 Development of Germinal Centers in Phylogenesis and Ontogenesis.- The Phylogenetic Development of Immune Responses and the Germinal Center System.- Ontogenetic Development of the Germinal Centers and Their Function - Relationship to the Bursa of Fabricius.- Germinal Centers in the Tonsilla Caecalis - Relationship to the Thymus and the Bursa of Fabricius.- Discussion.- Session 2 Histological Structure of Germinal Centers.- The Formation of Germinal Centers in the Medulla of Lymph Nodes.- Session 3 Ultrastructure of Germinal Centers.- Electron Microscopic Studies of Germinal Centers in Man.- Ultrastructural Modifications of the Lymph Nodes after Homologous Skin Grafting in the Mouse.- Observations on the Ultrastructure of Lymphatic Tissue Germinal Centers.- Discussion.- Session 4 Localization of Antigen and Immune Complexes in Lymphoreticular Tissue with Special References to Germinal Centers.- Localization of ?-Globulin and Labeled Antigen in Germinal Centers in Relation to the Immune Response.- Lymphatic Tissue Germinal Center Localization of 125I-labeled Heterologous and Isologous Macroglobulins.- Basic Peptides Produced in Polymorphonuclear Leucocytes and Thymus - Evidence of Complexes with Serum Globulins.- Discussion.- Session 5 Immunohistodiemistry of Germinal Centers and Plasmocytoid Cells.- The Morphologic Demonstration of Antibody Formation in Follicles of Lymphoid Tissue.- The Immunoglobulins Present in the Germinal Centers.- Synthesis of Human Immunoglobulins in Germinal Centers.- Lymph Node Plasma Cell Production in Secondary Immune Response.- Germinal Center Formation and Antigen Localization in Malpighian Bodies of the Chicken Spleen.- Discussion.- Session 6 Cellular Kinetics of Lymphoid Cells, with Special Reference to Germinal Centers.- Radioautographic Studies of Reticular and Lymphoid Cells in Germinal Centers of Lymph Nodes.- Thymidine-3H in Developing Germinal Centers.- Mitotic Activity of Two Cnromosomally Marked Populations of Cells in an Immune Response.- Lymphoid Cell Lines in the Thoracic Duct of the Calf with Different Generation Times.- Discussion.- Session 7 Lymphoid Cell Migration.- The Integrity of the Germinal Center: An Investigation of the Differential Localization of Labeled Cells in Lymphoid Organs.- Cell Production and Cell Migration in the Tonsil.- The Fate of Lymphoid Cells from the White Pulp at the Peak of Germinal Center Formation.- Morphologic and Autoradiographic Studies of Spleen White Pulp Germinal Centers after Antigen Injection.- Quantitative Studies of Lymphocyte Mobilization and Uptake of Antigen by Lymphocytes during Primary Antibody Response against Protein Antigens.- Discussion.- Session 8 Mechanism and Significance of Cell Death within Germinal Centers.- Kinetics of Cellular Death in Germinal Centers of Mouse Spleen.- On the Origin of Tingible Bodies in Germinal Centers.- Discussion.- Session 9 Effects of Noxious Agents on Germinal Centers.- The Effects of Immuno Suppressant Drugs Administered During Germinal Center Proliferation on Preparation for a Secondary Antibody Response in Rabbits.- Comparative Changes in the Mouse Spleen During Immunostimulation or Immunosuppression.- Effects of Local Irradiation of the Spleen on the Primary Response in Rats (Histologic and Serologic Study).- Regeneration Patterns of Lymphoid Follicles in the Rabbit Spleen after Sublethal X-irradiation.- Discussion.- Session 10 Germinal Centers and their Relationship to Plasmocytogenesis and the Production of Humoral Antibodies.- The Production of Memory Cells by the White Pulp of the Spleen in Rabbits.- De novo Formation and Rapid Growth of Germinal Centers During Secondary Antibody Responses to Tetanus Toxoid in Mice.- Germinal Centers Allograft Sensitivity and Iso-antibody Formation in Skin Allografted Mice.- Recent Observations on the Origin and Fate of Antigen-Stimulated Cells in the Rat Spleen.- Discussion.- Session 11 Behavior of Germinal Centers in Delayed Hypersensitivity.- In vitro Studies of Cell-bound Immunity Induced by Tumor Allografts; Inhibitory Effects of Iso-antibody.- Immune Response of Lymph Nodes to Skin Allografts: Effects of Proteolytic Enzymes and of an Inhibitor of the Proteolysis.- Germinal Center Activity in Relation to Delayed Hypersensitivity.- Discussion.- Session 12 Germinal Centers in Tolerant States.- The Effect of Antigen Dose on the Changes in the Spleen: Tolerance versus Immunity.- Lymphoid Regeneration Following x-Ray Treatment and the Susceptibility to the Induction of Immunological Tolerance.- The Cellular Components in the Induction of Antibody by x-Irradiated Animals.- Discussion.- Session 13 Germinal Centers in Germfree Animals.- Germfree Animals (Introductory Remarks to Session on Germfree Animals).- Germinal Centers in Germfree Animals.- Discussion.- Session 14 Development of Germinal Centers in Perinatally Thymectomized Animals.- Histological and Autoradiographic Studies on the Follicles of Neonatally Thymectomized Mice.- Development of Lymphatic Tissues in Early Thymectomized "Swiss Albino" Mice.- The Definition of a Germinal Center Area as Distinct from the Thymus-Dependent Area in the Lymphoid Tissue of the Mouse.- Lymphoid Restoration of Neonatally Thymectomized Mice with Thymus Epithelial Reticular Cell Remnants.- Germinal Centers and Plasma Cells in the Thymus of the Chicken.- Discussion.- Session 15 Behavior of Germinal Centers in Various Diseases and States with Disturbed Immunological Reactivity.- Immunological Deficiency Diseases of Man-Relationships to Disturbances of Germinal Center Formation.- Discussion.- Session 16 Germinal Centers in Autoimmune Disease.- Germinal Centers in Autoimmune Disease.- Germinal Centers in Autoimmune Disease.- Discussion.- Session 17 Germinal Centers in Various Neoplastic Diseases.- Tumor Resistance and Tumor Enhancement with SV40 Virus-induced Tumors.- Human Germinal Centers Lymph Nodes Responses to Leukemogenic Viruses in vitro.- Germinal Centers in Malignant Trophoblastic Disease.- Cytochemical Investigation on Normal and Pathological Lymph Nodes.- Discussion.- Session 18 Neoplastic Diseases Orginating from Germinal Center Cells.- Lymphomagenesis in Relation to Germinal Centers and to the Bursa of Fabricius.- The Giant Follicular Lymphoma (Brill-Symmers' Disease).- Discussion.- General Discussion.- Summary and Closing Remarks.- Authors Index.