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Germinal Centers in Immune Responses
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
978-3-540-03807-8 (ISBN)
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A rather large space has been devoted to the lively discussions which followed the reports, the volume of most of which had been voluntarily limited. The discussions are not reported verbatim but care has been taken to insure neutrality and objectivity in the necessary adaptation of the shortened transcription. We have been very fortunate indeed, to have Drs.
Comparison of Existing Theories on the Function of Germinal Centers.- Discussion.- Session 1 Development of Germinal Centers in Phylogenesis and Ontogenesis.- The Phylogenetic Development of Immune Responses and the Germinal Center System.- Ontogenetic Development of the Germinal Centers and Their Function - Relationship to the Bursa of Fabricius.- Germinal Centers in the Tonsilla Caecalis - Relationship to the Thymus and the Bursa of Fabricius.- Discussion.- Session 2 Histological Structure of Germinal Centers.- The Formation of Germinal Centers in the Medulla of Lymph Nodes.- Session 3 Ultrastructure of Germinal Centers.- Electron Microscopic Studies of Germinal Centers in Man.- Ultrastructural Modifications of the Lymph Nodes after Homologous Skin Grafting in the Mouse.- Observations on the Ultrastructure of Lymphatic Tissue Germinal Centers.- Discussion.- Session 4 Localization of Antigen and Immune Complexes in Lymphoreticular Tissue with Special References to Germinal Centers.- Localization of ?-Globulin and Labeled Antigen in Germinal Centers in Relation to the Immune Response.- Lymphatic Tissue Germinal Center Localization of 125I-labeled Heterologous and Isologous Macroglobulins.- Basic Peptides Produced in Polymorphonuclear Leucocytes and Thymus - Evidence of Complexes with Serum Globulins.- Discussion.- Session 5 Immunohistodiemistry of Germinal Centers and Plasmocytoid Cells.- The Morphologic Demonstration of Antibody Formation in Follicles of Lymphoid Tissue.- The Immunoglobulins Present in the Germinal Centers.- Synthesis of Human Immunoglobulins in Germinal Centers.- Lymph Node Plasma Cell Production in Secondary Immune Response.- Germinal Center Formation and Antigen Localization in Malpighian Bodies of the Chicken Spleen.- Discussion.- Session 6 Cellular Kinetics of Lymphoid Cells, with Special Reference to Germinal Centers.- Radioautographic Studies of Reticular and Lymphoid Cells in Germinal Centers of Lymph Nodes.- Thymidine-3H in Developing Germinal Centers.- Mitotic Activity of Two Cnromosomally Marked Populations of Cells in an Immune Response.- Lymphoid Cell Lines in the Thoracic Duct of the Calf with Different Generation Times.- Discussion.- Session 7 Lymphoid Cell Migration.- The Integrity of the Germinal Center: An Investigation of the Differential Localization of Labeled Cells in Lymphoid Organs.- Cell Production and Cell Migration in the Tonsil.- The Fate of Lymphoid Cells from the White Pulp at the Peak of Germinal Center Formation.- Morphologic and Autoradiographic Studies of Spleen White Pulp Germinal Centers after Antigen Injection.- Quantitative Studies of Lymphocyte Mobilization and Uptake of Antigen by Lymphocytes during Primary Antibody Response against Protein Antigens.- Discussion.- Session 8 Mechanism and Significance of Cell Death within Germinal Centers.- Kinetics of Cellular Death in Germinal Centers of Mouse Spleen.- On the Origin of Tingible Bodies in Germinal Centers.- Discussion.- Session 9 Effects of Noxious Agents on Germinal Centers.- The Effects of Immuno Suppressant Drugs Administered During Germinal Center Proliferation on Preparation for a Secondary Antibody Response in Rabbits.- Comparative Changes in the Mouse Spleen During Immunostimulation or Immunosuppression.- Effects of Local Irradiation of the Spleen on the Primary Response in Rats (Histologic and Serologic Study).- Regeneration Patterns of Lymphoid Follicles in the Rabbit Spleen after Sublethal X-irradiation.- Discussion.- Session 10 Germinal Centers and their Relationship to Plasmocytogenesis and the Production of Humoral Antibodies.- The Production of Memory Cells by the White Pulp of the Spleen in Rabbits.- De novo Formation and Rapid Growth of Germinal Centers During Secondary Antibody Responses to Tetanus Toxoid in Mice.- Germinal Centers Allograft Sensitivity and Iso-antibody Formation in Skin Allografted Mice.- Recent Observations on the Origin and Fate of Antigen-Stimulated Cells in the Rat Spleen.- Discussion.- Session 11 Behavior of Germinal Centers in Delayed Hypersensitivity.- In vitro Studies of Cell-bound Immunity Induced by Tumor Allografts; Inhibitory Effects of Iso-antibody.- Immune Response of Lymph Nodes to Skin Allografts: Effects of Proteolytic Enzymes and of an Inhibitor of the Proteolysis.- Germinal Center Activity in Relation to Delayed Hypersensitivity.- Discussion.- Session 12 Germinal Centers in Tolerant States.- The Effect of Antigen Dose on the Changes in the Spleen: Tolerance versus Immunity.- Lymphoid Regeneration Following x-Ray Treatment and the Susceptibility to the Induction of Immunological Tolerance.- The Cellular Components in the Induction of Antibody by x-Irradiated Animals.- Discussion.- Session 13 Germinal Centers in Germfree Animals.- Germfree Animals (Introductory Remarks to Session on Germfree Animals).- Germinal Centers in Germfree Animals.- Discussion.- Session 14 Development of Germinal Centers in Perinatally Thymectomized Animals.- Histological and Autoradiographic Studies on the Follicles of Neonatally Thymectomized Mice.- Development of Lymphatic Tissues in Early Thymectomized "Swiss Albino" Mice.- The Definition of a Germinal Center Area as Distinct from the Thymus-Dependent Area in the Lymphoid Tissue of the Mouse.- Lymphoid Restoration of Neonatally Thymectomized Mice with Thymus Epithelial Reticular Cell Remnants.- Germinal Centers and Plasma Cells in the Thymus of the Chicken.- Discussion.- Session 15 Behavior of Germinal Centers in Various Diseases and States with Disturbed Immunological Reactivity.- Immunological Deficiency Diseases of Man-Relationships to Disturbances of Germinal Center Formation.- Discussion.- Session 16 Germinal Centers in Autoimmune Disease.- Germinal Centers in Autoimmune Disease.- Germinal Centers in Autoimmune Disease.- Discussion.- Session 17 Germinal Centers in Various Neoplastic Diseases.- Tumor Resistance and Tumor Enhancement with SV40 Virus-induced Tumors.- Human Germinal Centers Lymph Nodes Responses to Leukemogenic Viruses in vitro.- Germinal Centers in Malignant Trophoblastic Disease.- Cytochemical Investigation on Normal and Pathological Lymph Nodes.- Discussion.- Session 18 Neoplastic Diseases Orginating from Germinal Center Cells.- Lymphomagenesis in Relation to Germinal Centers and to the Bursa of Fabricius.- The Giant Follicular Lymphoma (Brill-Symmers' Disease).- Discussion.- General Discussion.- Summary and Closing Remarks.- Authors Index.
Zusatzinfo | 194 black & white illustrations, biography |
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Verlagsort | Berlin |
Sprache | englisch |
Gewicht | 1220 g |
Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
ISBN-10 | 3-540-03807-8 / 3540038078 |
ISBN-13 | 978-3-540-03807-8 / 9783540038078 |
Zustand | Neuware |
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