The Molecular Basis of Blood Diseases

PART I: Hematopoiesis Stem Cell Biology Hemopoietic Growth Factors and Receptors Transcriptional Factors that Regulate Lineage Decisions Growth Factor Signaling PART II: Red Cells Hemoglobin Switching The Thalassemias Human Hemoglobins: Sickle Cell Hemoglobin and Other Mutants The Erythrocyte Membrane and Cytoskeleton: Structure, Function, and Disorders Red Blood Cell Antigenes Molecular Basis of Iron Metabolism PART III: Lymphopoiesis Gene rearrangements in Lymhoic Cells Lymphoiesis Antigen Processing and T-Cell Effector Mechanisms PART IV: Myelopoiesis/White Blood Cells Integrins, Selectins, and LAD Chemokines Genetic Disorders of Phagocyte Function Paroxymal Nocturnal Hemoglobins PART V: Hemostasis Vitamin K-Dependent Proteins The Protein C Anticoagulant System Regulation of Blood Coagulation by Protease Inhibitors Hemophilia A, Hemophilia B, and von Willenbrand Disease The Molecular Basis of Fibrin Fibrinilysis and the Control of Hemostasis Platelets PART VI: Molecular Oncology Molecular Aspects of Oncogenesis Mechanisms of Leukemogenesis PART VII: Viruses The Molecular and Biological Properties of the Human Immunodeficiency Virus Viral Pathogenesis of Hematological Disorders B19 Parvoviruses HTLVs Herpesviruses Gene Therapy of Hemopoietic Diseases