Non-Alcoholic Fatty Liver Disease (eBook)

List of Contributors, vii

1 What is non-alcoholic fatty liver disease (NAFLD), and why is
it important? 1

Geoffrey C. Farrell, Arthur J. McCullough, and Christopher P.
Day

2 NAFLD in the community, 17

Leon A. Adams

3 Pathology of NAFLD, 27

Elizabeth M. Brunt and David E. Kleiner

4 The natural history of NAFLD, 37

Paul Angulo

5 Emerging concepts on the pathogenesis of non-alcoholic
steatohepatitis (NASH), 46

Isabelle A. Leclercq

6 Diabetes and NAFLD: why is the connection important? 62

Elisabetta Bugianesi

7 NAFLD and cardiovascular risk factors: implications for
vascular disease, 71

Giovanni Targher

8 A primary care perspective of fatty liver: diagnosis,
management, prescribing, and when to refer, 84

Shivakumar Chitturi and Geoffrey C. Farrell

9 Imaging of NAFLD, 93

Takeshi Yokoo, An Tang, and Claude B. Sirlin

10 Non-invasive methods to determine the severity of NAFLD and
NASH, 112

Vincent Wai-Sun Wong and Henry Lik-Yuen Chan

11 Fatigue, quality of life, and psychosocial issues for people
with NAFLD, 122

Julia L. Newton and James Frith

12 Physical activity and cardiovascular fi tness in patients
with NAFLD: clinical importance and therapeutic implications,
132

Ingrid J. Hickman, Graeme A. Macdonald, and Nuala M.
Byrne

13 NAFLD, obesity, and bariatric surgery, 149

Philippe Mathurin

14 Genetic predisposition to NAFLD and NASH: implications for
pathogenesis, diagnosis, prevention, and management, 157

Quentin M. Anstee, Ann K. Daly, and Christopher P. Day

15 NAFLD in children, 171

Ariel E. Feldstein

16 The pointy end of the NAFLD iceberg: cirrhosis, portal
hypertension, and liver failure, 182

Jonathon W. Schwake, Dawn M. Torres, and Stephen A.
Harrison

17 Non-alcoholic fatty liver disease, hepatocellular cancer, and
other cancers, 192

Janine Graham and Helen L. Reeves

18 NAFLD in Chinese and South Asian people, 206

Jia-Horng Kao, Deepak Amarapurkar, and Jian-Gao Fan

19 Non-alcoholic fatty liver disease in Japan, 217

Takeshi Okanoue, Kohichiroh Yasui, and Yoshito Itoh

20 Non-alcoholic fatty liver disease in South America and
Hispanic people, 228

Helma Pinchemel Cotrim and Carla Daltro

21 Alcohol in non-alcoholic fatty liver disease: an oxymoron or
a new standard of care?, 234

Achuthan Sourianarayanane, Srinivasan Dasarathy, and Arthur J.
McCullough

22 Dietary factors in the pathogenesis and care of patients with
fatty liver disease, 248

Giulio Marchesini, Rebecca Marzocchi, Anna S. Sasdelli,
Cristiana Andruccioli, and Silvia Di Domizio

23 Metabolic factors and steatosis in patients with hepatitis B
and C, 260

Francesco Negro

24 Drug therapy for NASH: insulin-sensitizing agents (metformin
and thiazolidinediones), 271

Mohammad S. Siddiqui and Arun J. Sanyal

25 Hepatoprotectants against fatty liver disease: antioxidants,
ursodeoxycholic acid, and herbal medicines, 284

Anne Catherine Bürgi and Jean-François Dufour

26 Lipid modifiers and NASH: statins, ezetimibe, fibrates, and
other agents, 293

Giovanni Musso, Federica Molinaro, Elena Paschetta, Roberto
Gambino, and Maurizio Cassader

Index, 308

Color plate section facing p86

"This book is useful for anyone who cares for patients
with NAFLD -- specialist or generalist. It provides both a general
overview as well as a detailed look at disease mechanisms, clinical
assessment, diagnosis, and treatment. It comes out in a timely
fashion as diseases such as diabetes, obesity, metabolic syndrome,
NAFLD, and NASH are on the rise."
(Doody's, 24 January 2014)