Challenges in Colorectal Cancer (eBook)

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2008 | 2. Auflage
296 Seiten
Wiley (Verlag)
978-0-470-75322-4 (ISBN)

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The latest guidance on challenging and controversial aspects of colorectal cancer

Colorectal cancer is one of the most common forms of cancer in the US and Europe. Thousands of people are diagnosed with the disease every year and nearly half of these die as a result. As colorectal cancer is curable when detected early, a significant proportion of these deaths could be prevented by earlier diagnosis.

Much has changed since the publication of the first edition of this book in 2001: introduction of screening programs, improved diagnosis and surgery for rectal cancer, and advances in adjuvant and palliative medical therapy to name but a few.

Challenges in Colorectal Cancer provides the most up-to-date information on the new and emerging treatments. The second edition looks at the total patient management of this condition and is aimed at the entire medical team caring for those with colorectal cancer. It also contains the latest guidelines on epidemiology and prevention of colorectal cancer, and the application of molecular genetics.

The expanded international editor team present advice on surgical management, including new laparoscopic and endoscopic techniques and the role of the pathologist. They also review hot topics in colorectal cancer treatment, including the role of radiotherapy, options for chemotherapy and new developments in vaccines and immunotherapy.



Professor John Scholefield is Professor of surgery at University Hospital in Nottingham. He is doing research into possible screening tests for spotting colorectal cancer early and cell changes in colorectal cancer. He chairs the National Cancer Research Institute's colorectal cancer group, and is also a member of Council of the Association of Surgeons.


Professor Herand Abcarian MD FACS, Turi Josefsen Professor and Chairman of the Department of Surgery, University of Illinois College of Medicine at Chicago, USA.


Professor Tim Maughan, Professor of Cancer Studies at the University of Wales, College of Medicine, and Consultant Clinical Oncologist at the Velindre Hospital Swansea. Also Chairman of the All Wales Cancer Network.


Professor Axel Grothey, Mayo Clinic, USA (formerly Professor of Medicine and Oncology at Martin Luther University, Halle, Germany).


The latest guidance on challenging and controversial aspects of colorectal cancer Colorectal cancer is one of the most common forms of cancer in the US and Europe. Thousands of people are diagnosed with the disease every year and nearly half of these die as a result. As colorectal cancer is curable when detected early, a significant proportion of these deaths could be prevented by earlier diagnosis. Much has changed since the publication of the first edition of this book in 2001: introduction of screening programs, improved diagnosis and surgery for rectal cancer, and advances in adjuvant and palliative medical therapy to name but a few. Challenges in Colorectal Cancer provides the most up-to-date information on the new and emerging treatments. The second edition looks at the total patient management of this condition and is aimed at the entire medical team caring for those with colorectal cancer. It also contains the latest guidelines on epidemiology and prevention of colorectal cancer, and the application of molecular genetics. The expanded international editor team present advice on surgical management, including new laparoscopic and endoscopic techniques and the role of the pathologist. They also review hot topics in colorectal cancer treatment, including the role of radiotherapy, options for chemotherapy and new developments in vaccines and immunotherapy.

Professor John Scholefield is Professor of surgery at University Hospital in Nottingham. He is doing research into possible screening tests for spotting colorectal cancer early and cell changes in colorectal cancer. He chairs the National Cancer Research Institute's colorectal cancer group, and is also a member of Council of the Association of Surgeons. Professor Herand Abcarian MD FACS, Turi Josefsen Professor and Chairman of the Department of Surgery, University of Illinois College of Medicine at Chicago, USA. Professor Tim Maughan, Professor of Cancer Studies at the University of Wales, College of Medicine, and Consultant Clinical Oncologist at the Velindre Hospital Swansea. Also Chairman of the All Wales Cancer Network. Professor Axel Grothey, Mayo Clinic, USA (formerly Professor of Medicine and Oncology at Martin Luther University, Halle, Germany).

CHALLENGES IN: Colorectal Cancer 5
Contents 7
List of contributors 9
Foreword 13
1 Does lifestyle cause colorectal cancer? 14
2 Screening for colorectal cancer – who, when, and how? 27
3 What can the pathologist tell the multidisciplinary team about rectal cancer resection? 44
4 MRI-directed rectal cancer surgery 59
5 Minimally invasive surgery – where are we? Laparoscopic surgery for cancer of the colon and rectum 73
6 Minimally invasive surgery – where are we? Is there a role for TEM? 86
7 What is the best strategy for the management of hereditary colorectal cancer? 102
8 Adjuvant radiotherapy and chemoradiotherapy in the treatment of rectal cancer 125
9 Current challenges in the adjuvant therapy of colon cancer 146
10 The role of the colorectal nurse specialist in the management of colorectal cancer 166
11 The role of the multidisciplinary team in the management of colorectal cancer 180
12 Follow-up after colorectal cancer resection: Is it worthwhile? 191
13 Chemotherapy of advanced colorectal cancer 208
14 Surgery for metastatic disease in colorectal cancer 226
15 Palliative care of the colorectal cancer patient 245
16 Future directions in the oncological treatment of colorectal cancer 264
Index 284

"The text is extremely well references and well illustrated and provides a worthwhile edition to the library of all workers in the field."
Colorectal Disease, 2007

"A good book looking at the total management of patients with this condition and aimed at the entire medical team caring fro those with colorectal cancer."
Digestive and Liver Disease, 2007

From a review of the first edition:
"More knowledge of molecular biology, better definition of risk groups, better screening, further development of risk- oriented combination therapy, and more meticulous surgery may yield much higher cure rates for colon and rectal cancer. Scholefield's book is one of the best starting points for a journey through the world of established, new, and evolving treatments for these diseases."
New England Journal of Medicine, September 2000

"Robert W Beart, Jr., states in the foreword that this book provides an "up-to-date record of the rapidly evolving alternatives" in chapters which span the gamut from prevention through palliation. It is written for subspecialist physicians, nurses, and other members of the medical team. The emphasis throughout is providing this team with concrete, useful information. Although the authors are predominantly from the U.K., European and American issues are identified throughout." (Carol Scott-Conner, MD, PhD, MBA, @Doody's Review Service)

"The text is extremely well references and well illustrated and
provides a worthwhile edition to the library of all workers in the
field."

Colorectal Disease, 2007

"A good book looking at the total management of patients with
this condition and aimed at the entire medical team caring fro
those with colorectal cancer."

Digestive and Liver Disease, 2007

From a review of the first edition:

"More knowledge of molecular biology, better definition
of risk groups, better screening, further development of risk-
oriented combination therapy, and more meticulous surgery may yield
much higher cure rates for colon and rectal cancer.
Scholefield's book is one of the best starting points for a
journey through the world of established, new, and evolving
treatments for these diseases."

New England Journal of Medicine, September 2000

Erscheint lt. Verlag 15.4.2008
Sprache englisch
Themenwelt Medizin / Pharmazie Allgemeines / Lexika
Medizinische Fachgebiete Innere Medizin Gastroenterologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Schlagworte Gastroenterologie • gastroenterology • Medical Science • Medizin • Pathologie • Pathology
ISBN-10 0-470-75322-6 / 0470753226
ISBN-13 978-0-470-75322-4 / 9780470753224
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