Metabolic Syndrome (eBook)

MINGHAN "MING" WANG, PHD is Director and head of a metabolism group in Metabolic Disorders Research at Amgen. He has authored over forty publications and is a regular speaker at drug discovery conferences.

Introduction ix
Minghan Wang

Contributors xi

Part One The Physiology of Metabolic Tissues Under Normal and Disease States

1. Gut as an Endocrine Organ: the Role of Nutrient Sensing in Energy Metabolism 3
Minghan Wang

2. Central Glucose Sensing and Control of Food Intake and Energy Homeostasis 29
Lourdes Mounien and Bernard Thorens

3. Abnormalities in Insulin Secretion in Type 2 Diabetes Mellitus 53
Taly Meas and Pierre-Jean Guillausseau

4. Adipokine Production by Adipose Tissue: A Novel Target for Treating Metabolic Syndrome and its Sequelae 73
Vanessa DeClercq, Danielle Stringer, Ryan Hunt, Carla G. Taylor, and Peter Zahradka

5. Hepatic Metabolic Dysfunctions in Type 2 Diabetes: Insulin Resistance and Impaired Glucose Production and Lipid Synthesis 133
Ruojing Yang

6. Energy Metabolism in Skeletal Muscle and its Link to Insulin Resistance 157
Minghan Wang

Part Two Metabolic Diseases and Current Therapies

7. Mechanisms and Complications of Metabolic Syndrome 179
Minghan Wang

8. Emerging Therapeutic Approaches for Dyslipidemias Associated with High LDL and Low HDL 199
Margrit Schwarz and Jae B. Kim

9. Mechanism of Action of Niacin: Implications for Atherosclerosis and Drug Discovery 235
Devan Marar, Shobha H. Ganji, Vaijinath S. Kamanna, and Moti L. Kashyap

10. Current Antidiabetic Therapies and Mechanisms 253
Minghan Wang

Part Three Drug Targets for Antidiabetic Therapies

11. GLP-1 Biology, Signaling Mechanisms, Physiology, and Clinical Studies 281
Remy Burcelin, Cendrine Cabou, Christophe Magnan, and Pierre Gourdy

12. Dipeptidyl Peptidase IV Inhibitors for Treatment of Diabetes 327
C.H.S. McIntosh, S.-J. Kim, R.A. Pederson, U. Heiser, and H.-U. Demuth

13. Sodium Glucose Cotransporter 2 Inhibitors 359
Margaret Ryan and Serge A. Jabbour

14. Fibroblast Growth Factor 21 as a Novel Metabolic Regulator 377
Radmila Micanovic, James D. Dunbar, and Alexei Kharitonenkov

15. Sirtuins as Potential Drug Targets for Metabolic Diseases 391
Qiang Tong

16. 11beta-Hydroxysteroid Dehydrogenase Type 1 as a Therapeutic Target for Type 2 Diabetes 423
Clarence Hale and David J. St. Jean, Jr.

17. Monoclonal Antibodies for the Treatment of Type 2 Diabetes: A Case Study with Glucagon Receptor Blockade 459
Hai Yan, Wei Gu, and Murielle Veniant-Ellison

Part Four Lessons Learned and Future Outlook

18. Drug Development for Metabolic Diseases: Past, Present and Future 471
Minghan Wang

Index 489

"This is an outstanding addition to the current body of work on the metabolic syndrome. I thought it particularly exhaustive in its review of the literature, making it an excellent resource for scouring the primary literature, and found the duality of current and future treatment approaches particularly insightful." (Doody's, 21 October 2011)

"The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications." (Pharmiweb, 1 March 2011)