Cardiovascular Effects of Inhaled Ultrafine and Nano-Sized Particles (eBook)

Flemming R. Cassee is head of the Department of Inhalation Toxicology, deputy head of the Center for Environmental Health, and leader of the program on air pollution and health at the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Nicholas L. Mills is a British Heart Foundation Clinical Fellow at the University of Edinburgh and Specialist Registrar in Cardiology at the Royal Infirmary of Edinburgh. David E. Newby is the British Heart Foundation John Wheatley Chair of Cardiology at the University of Edinburgh. He is a Consultant Interventional Cardiologist at the Royal Infirmary of Edinburgh, Director of the Wellcome Trust Clinical Research Facility, Director of the Clinical Research Imaging Centre, and Director of Research and Development for NHS Lothian.

FOREWORD.

PREFACE.

THE EDITORS.

CONTRIBUTORS.

PART I. ISSUE FRAMING.

CHAPTER 1 OVERVIEW (Flemming R. Cassee and MortonLippmann).

CHAPTER 2 ACUTE EFFECTS OF PARTICULATE MATTER ON THERISK OF MYOCARDIAL INFARCTION (Krishnan Bhaskaran, Shakoor Hajat,and Liam Smeeth).

CHAPTER 3 CHRONIC EFFECTS OF AIR POLLUTION ONCARDIOVASCULAR HEALTH (Ranjini M. Krishnan, Joel Kaufman, andGerard Hoek).

PART II. EXPOSURE.

CHAPTER 4 PARTICLE CHARACTERIZATION (Thomas A.J.Kuhlbusch and Christof Asbach).

CHAPTER 5 EXPOSURE ASSESSMENT FOR AMBIENT ULTRAFINEPARTICLES (Timo Lanki, Josef Cyrys, H.-Erich Wichmann, and Jeroende Hartog).

CHAPTER 6 FROM EXPOSURE TO DOSE (Werner Hofmann andBahman Asgharian).

CHAPTER 7 TRANSLOCATION OF INHALED NANOPARTICLES(Wolfgang G. Kreyling, Winfried Möller, Otmar Schmid, ManuelaSemmler-Behnke, and Günter Oberdörster).

CHAPTER 8 ROLE OF CHEMICAL COMPOSITION INDETERMINING THE CARDIOVASCULAR EFFECTS OF PARTICLES (Andrew J. Ghioand Yuh-Chin T. Huang).

PART III. METHODOLOGY.

CHAPTER 9 IN VITRO STUDIES (Per E. Schwarze andGerrit M. Alink).

CHAPTER 10 EXPERIMENTAL STUDIES IN ANIMALS (UrmilaP. Kodavanti, Lung-Chi Chen, and Daniel L. Costa).

CHAPTER 11 HUMAN EXPOSURE STUDIES (Jeremy P.Langrish, Mark W. Frampton, and Anders Blomberg).

CHAPTER 12 PANEL STUDIES (Joel Schwartz).

PART IV. PARTICLES AND CARDIOVASCULAR DISEASE:MECHANISMS.

A. ATHEROGENESIS.

CHAPTER 13 PARTICULATES AND OXIDATIVE STRESS(Steffen Loft, Roel P.F. Schins, and Peter Møller).

CHAPTER 14 ROLE OF INFLAMMATION IN THE ATHEROGENICEFFECTS OF PARTICULATE MATTER (Thomas Sandström and DavidNewby).

CHAPTER 15 INHALED PARTICLES, POSTPRANDIAL LIPIDS,AND THEIR POSSIBLE CONTRIBUTION TO ATHEROGENESIS: THE TROJANHORSE HYPOTHESIS (Carlijne Hassing, Maarten J.M. Cramer, and MarcelTh.B. Twickler).

CHAPTER 16 INHALED PARTICULATE MATTER ANDATHEROSCLEROSIS IN HUMANS (Barbara Hoffmann and NinoKünzli).

CHAPTER 17 EFFECTS OF NANOPARTICLES ON THE PULMONARYVASCULATURE (Laurel E. Plummer, Kent E. Pinkerton, Amy K. Madl, andDennis W. Wilson).

CHAPTER 18 PARTICULATE MATTER, HYPERTENSION, AND THEMETABOLIC SYNDROME (Robert D. Brook and Sanjay Rajagopalan).

CHAPTER 19 PARTICLES AND THE VASCULAR ENDOTHELIUM(Nicholas L. Mills and Mark R. Miller).

PART IV. PARTICLES AND CARDIOVASCULAR DISEASE:MECHANISMS.

B. VASCULAR DYSFUNCTION.

PART IV. PARTICLES AND CARDIOVASCULAR DISEASE:MECHANISMS.

C. THROMBOSIS.

CHAPTER 20 PARTICLES, COAGULATION, AND THROMBOSIS(Evren Kilinç, Goran Rudez, Henri M.H. Spronk, AbderrahimNemmar, Moniek P.M. de Maat, Hugo ten Cate and Marc F.Hoylaerts).

CHAPTER 21 PARTICLES AND THE PATHOGENESIS OFATHEROTHROMBOSIS (Qinghua Sun and Xiaohua Xu).

PART IV. PARTICLES AND CARDIOVASCULAR DISEASE:MECHANISMS.

D. ARRHYTHMIA.

CHAPTER 22 PARTICLES AND THE AUTONOMIC NERVOUSSYSTEM (Swapna Upadhyay, Alison Elder, Wayne E. Cascio, and HolgerSchulz).

CHAPTER 23 AIR POLLUTION AND ARRHYTHMIA (Helen C.Routledge and Jonathan N. Townend).

PART V. ENVIRONMENTAL AND PUBLIC HEALTH POLICY.

CHAPTER 24 RISK ASSESSMENT (Robert L. Maynard andJon G. Ayres).

CHAPTER 25 ENVIRONMENTAL REGULATION OF PARTICULATEMATTER (Richard Damberg, Klaas Krijgsheld, May Ajero, and SophiePunte).

CHAPTER 26 FROM AMBIENT ULTRAFINE PARTICLES TONANOTECHNOLOGY AND NANOTOXICOLOGY (Ken Donaldson and David B.Warheit).

INDEX.

"It is timely and detailed in its account of complex issues
attending air pollution related to the cardiovascular and
cardiopulmonary systems. . . This book could well be the most
important occupational and environmental health book I have ever
read." (Doody's, 16 September 2011)