Oral Delivery of Insulin

Sonia T.A pursued her PhD under the guidance of Dr Chandra P Sharma at the Biosurface Technology Division, Sree Chitra Tirunal Institute for Medical Science & Technology in Kerala, India. She worked in the field of development of polymeric nano/micro particles for oral delivery of insulin. She completed her graduate studies in Polymer science from the School of Chemical Sciences, Mahatma Gandhi University, Kerala India. She has presented her work in International Conferences. Dr. Chandra P. Sharma is Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering & Applied Sciences, Purbanchal University, Kathmandu, Nepal. Dr. Sharma is a Solid-State Physicist from IIT Delhi and received his training in Biomaterials area in the University of Utah with Prof. D.J. Lyman as a graduate student and in the University of Liverpool, England with Prof. D.F. Williams as a Post-Doctoral Research Associate. Dr. Sharma has been awarded FBSE (Fellow Biomaterials Science & Engineering) by The International Union of Societies for Biomaterials Science & Engineering (IUS-BSE) in 2008 and FBAO (Fellow Biomaterials and Artificial Organs) by Society for Biomaterials & Artificial Organs (India) (SBAOI) in 2011 and shares Whitaker and National Science Foundation Award – International Society for Artificial Organs (ISAO) USA, invited member ACS (2015-2018).

List of figures and tables

Figures
Tables


About the authors
1: Diabetes mellitus – an overview

Abstract
1.1 Diabetes mellitus – an introduction
1.2 Glucose homeostasis
1.3 Types of diabetes
1.4 Symptoms of diabetes
1.5 Complications of diabetes
1.6 Diagnosis of diabetes mellitus
1.7 Therapy for diabetes
1.8 Non-insulin treatment options of type 1 diabetes
1.9 Treatment options of type 2 diabetes
1.10 Conclusion


2: Routes of administration of insulin

Abstract
2.1 Current approach for the delivery of insulin
2.2 Routes of administration of insulin
2.3 Conclusion


3: Oral insulin delivery – challenges and strategies

Abstract
3.1 Oral delivery of insulin
3.2 Barriers to oral delivery of insulin
3.3 Strategies and alternatives to improve oral insulin delivery
3.4 Conclusion


4: Experimental techniques involved in the development of oral insulin carriers

Abstract
4.1 Introduction
4.2 Polymeric nanoparticles
4.3 Physicochemical characterization of nanoparticles
4.4 Biological evaluation
4.5 In vitro method for assessing drug permeability
4.6 In vivo study of oral insulin
4.7 Biodistribution studies
4.8 Conclusion


5: Lipids and inorganic nanoparticles in oral insulin delivery

Abstract
5.1 Lipid-based systems for oral delivery of insulin
5.2 Liposomes
5.3 Solid lipid nanoparticles
5.4 Nanostructured lipid carriers
5.5 Niosomes
5.6 Archaeosomes
5.7 Cubic nanoparticles (cubosomes)
5.8 Aquasomes
5.9 Inorganic nanoparticles as carriers for oral insulin delivery
5.10 Conclusion


6: Polymers in oral insulin delivery

Abstract
6.1 Introduction
6.2 Characteristics of an ideal oral insulin carrier
6.3 Polymers in oral insulin delivery
6.4 Natural polymers
6.5 Synthetic polymers
6.6 Conclusion


7: Summary and future perspectives for oral insulin delivery

Abstract
7.1 Introduction
7.2 Technologies developed for clinical applications of oral insulin delivery
7.3 Conclusions and future perspectives


Index