Clinical Pharmacology and Therapeutics (eBook)

Gerard A. McKay: Consultant Physician and Honorary ClinicalSenior Lecturer, Glasgow Royal Infirmary John L. Reid: Emeritus Professor of Medicine andTherapeutics, University of Glasgow Matthew R. Walters: Professor of Clinical Pharmacologyand Honorary Consultant Physician, Division of Cardiovascular andMedical Sciences, University of Glasgow

Contributors, iv
Preface, vi
Acknowledgements, vii
Part 1 Principles of Clinical Pharmacology
1 Pharmacodynamics and pharmacokinetics, 3
2 Clinical trials and drug development, 12
Part 2 Aspects of Therapeutics
3 Drugs and gastrointestinal disease, 21
4 Management of coronary artery disease and its complications,33
5 Primary and secondary prevention of cardiovascular disease,58
6 Drugs used to treat respiratory disease, 78
7 Drugs used to treat neurological disease, 89
8 Treatment of psychiatric disorders, 108
9 Antimicrobial therapy, 124
10 HIV and antiretroviral treatment, 148
11 Travel medicine and tropical disease, 160
12 Drugs and endocrine disease, 171
13 Drugs and the reproductive system, 190
14 Drugs and the urological system, 199
15 Cancer therapeutics, 205
16 Immunopharmacology, 217
17 Corticosteroids, 225
18 Drugs and the blood including anticoagulants and thrombolyticdrugs, 229
19 Drugs and inflammatory joint disease, 244
20 Anaesthesia and the relief of pain, 254
Part 3 Practical Aspects of Prescribing
21 Clinical pharmacokinetics: dosage individualisation, 267
22 Influence of renal and hepatic disease on pharmacokineticsand pharmacodynamics, 273
23 Prescribing at extremes of age, 278
24 Drugs in pregnant and breastfeeding women, 282
25 Pharmacoeconomics: the economic evaluation of new drugs,290
26 Poisoning and drug overdose, 297
27 Drugs you may need in a hurry, 313
28 Prescribing and its pitfalls, 318
Index, 326