Genomic Regulatory Systems (eBook)
261 Seiten
Elsevier Science (Verlag)
978-0-08-052559-4 (ISBN)
The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.
* Contents Include
* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution
* Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression
* Regulation of Direct Cell-Type Specification in Early Development
* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.* Contents Include* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression* Regulation of Direct Cell-Type Specification in Early Development* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Front Cover 1
Genornic Regulatory Systems: Development and Evolution 4
Copyright Page 5
Contents 6
Preface 10
Chapter 1. Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and its Causal Role in Development and Evolution 14
The Regulatory Apparatus Encoded in the DNA 15
Gene Regulatory Functions in Development 24
Genomic Regulatory Sequence and the Evolution of Morphological Features 31
Chapter 2. Inside the cis-Regulatory Module: Control Logic, and How Regulatory Environment is Transduced into Spatial Patterns of Gene Expression 38
Operating Principles for cis -Regulatory Systems that Mediate Developmental Specification Events 39
Spatial Repression in cis -Regulatory specification 41
Downstream of Specification 57
The "Power" of the cis -Regulatory Module 62
Chapter 3. Regulation of Direct Cell-Type Specification in Early Development 76
The Basic Package for Bilaterian Embryogenesis: Type 1 Specification Processes 77
Regulatory Mechanism in Territorial Specification of the Sea Urchin Embryo 79
Regulatory Mechanisms Controlling Specification in Ascidian Embryos 94
Caenorhabditis elegans: The Genomic Apparatus for Endoderm Specification 105
Short Summary: Quality of Type 1 Regulatory Networks 114
Chapter 4. The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts 116
The Evolutionary Significance of "Pattern Formation" 116
The First Step: Transcriptional Definition of the Domain of the Body Part 118
Morphological Pieces and Regulatory Subpatterns 123
Glimpses of How It Works 135
The Last Routines: Calling in Differentiation Programs 159
Concluding Remark 166
Chapter 5. Changes that Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans 170
Some Examples: Evolutionary Cooption of Genes to New Pattern Formation Functions 171
box Gene Functions and Cooptions of the box Cluster Patterning System 177
Small Changes 196
Evolutionary Origins of Body Parts 201
Concluding Comment: Conceiving Evolution as a Process of Change in Regulatory Gene Networks 214
References 216
Index 258
Erscheint lt. Verlag | 24.1.2001 |
---|---|
Sprache | englisch |
Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie |
Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
Naturwissenschaften ► Biologie ► Ökologie / Naturschutz | |
Naturwissenschaften ► Biologie ► Zoologie | |
Technik | |
ISBN-10 | 0-08-052559-8 / 0080525598 |
ISBN-13 | 978-0-08-052559-4 / 9780080525594 |
Haben Sie eine Frage zum Produkt? |
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