Protein Kinase C in Cancer Signaling and Therapy (eBook)

Part I Regulation of PKC isozyme function: from genes to biochemistry Protein Kinase C in Cancer Signaling and Therapy, Introduction and Historical Perspective - Alex Toker Regulation of conventional and novel protein kinase C isozymes by phosphorylation and lipids - Alexandra Newton Phorbol esters and diacylglycerol: the PKC activators - Peter M. Blumberg Diacylglycerol signaling: the C1 domain, generation of DAG and termination of signals - Isabel Merida Regulation of PKC by protein-protein interactions in cancer - Daria Mochly-Rosen Part II PKC isozymes in the control of cell function Introduction: PKC isozymes in the control of cell function - Chris Larsson Regulation and function of protein kinase D signaling - Enrique Rozengurt PKC and control of the cell cycle - Jennifer Black PKC and the control of apoptosis - Mary Reyland Atypical PKCs, NF-kB and inflammation - Maria Teresa Diaz-Meco and Jorge Moscat Part III PKC isozymes in cancer Introduction. PKC isozymes in cancer - Marcelo G. Kazanietz PKC, p53, and DNA damage - Kiyotsugu Yoshida PKCs as mediators of the Hedgehog and Wnt pathways - Natalia Riobo PKC-PKD interplay in cancer - Jane Wang Transgenic mouse models to investigate functional specificity of protein kinase C isoforms in the development of squamous cell carcinoma, a non-melanoma human skin cancer - Ajit Verma PKC isozymes and skin cancer - Mitch Denning PKC isozymes and breast cancer - Sofia Merajver PKC and prostate cancer - Jeewon Kim and Marcelo Kazanietz. PKC and lung cancer - Lei Xiao Part IV PKC isozymes as targets for cancer therapy Introduction. PKC isozymes as targets for cancer therapy - Patricia Lorenzo PKC and resistance to chemotherapeutic agents - Alakhananda Basu PKCd as a target for chemotherapeutic drugs - Chaya Brodie Atypical PKCs as targets for cancer therapy - Alan Fields